Neuroimaging After Traumatic Brain Injury: What Best Relates To Outcome?
Funder
National Health and Medical Research Council
Funding Amount
$402,287.00
Summary
Brain injury often results in physical difficulties plus cognitive and behavioural problems. Computerised tomography (CT) is the most used form of scanning used after brain injury but does not reveal as much as Magnetic Resonance Imaging (MRI). Electrovestibulography (EvestG) also offers great potential to reveal brain-related information related to injury and depression. This study aims to assess and compare CT, MRI and EvestG to establish the extent to which each can help in predicting outcome ....Brain injury often results in physical difficulties plus cognitive and behavioural problems. Computerised tomography (CT) is the most used form of scanning used after brain injury but does not reveal as much as Magnetic Resonance Imaging (MRI). Electrovestibulography (EvestG) also offers great potential to reveal brain-related information related to injury and depression. This study aims to assess and compare CT, MRI and EvestG to establish the extent to which each can help in predicting outcome in people who have had a brain injury.Read moreRead less
I use multidisciplinary and neuroimaging approaches to understand how the biochemistry of the brain affects how the brain functions in health and disease. This basic science underpins treatment approaches and furthers our understanding of a wide range of brain disorders.
Identifying Neuroanatomical Sub-phenotypes Of Schizophrenia
Funder
National Health and Medical Research Council
Funding Amount
$60,129.00
Summary
The clinical presentation of schizophrenia is varied across individuals, and has arguably hindered efforts to determine its cause/s. This project seeks to address this issue by investigating biological commonality in patients, to identify subgroups of schizophrenia patients with similar brain abnormalities, with the overall aim to examine cognitive and clinical characteristics and candidate genetic markers in association with biologically derived subtypes of schizophrenia.
Social Functioning In Early Primary School Following Traumatic Brain Injury Prior To Age Three: The Contribution Of Cognitive, Environmental And Neurological Factors
Funder
National Health and Medical Research Council
Funding Amount
$394,501.00
Summary
Children of preschool age and older demonstrate social problems after a traumatic brain injury (TBI). What effect a TBI has on the social function of young children (before 3 years) is currently unknown but is thought that these children have more problems than older children do. This study will look at how a TBI impacts on the social function of young children and the role of cognition and brain development in social function will also be explored.
Development And Epilepsy - Strategies For Innovative Research To Improve Diagnosis, Prevention And Treatment In Children With Difficult To Treat Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$456,083.00
Summary
By deciphering pathophysiological mechanisms in epileptogenic developmental disorders and developing mechanism-related, and advanced therapeutic strategies, we expect to discover novel genes and related molecular pathways that are involved in epilepsy and similar disorders. DESIRE will also help preventing the development of the disease after potentially epileptogenic brain insults.
Development Of A Scorpion Toxin For Tumour Imaging
Funder
National Health and Medical Research Council
Funding Amount
$529,577.00
Summary
The aim of this project is to develop a tool for visualising tumours during surgery. Surgical removal of tumours remains the foundation of cancer treatment, but the ability to distinguish the margin between cancerous and healthy cells is imprecise. We will explore the potential of a scorpion toxin that selectively targets cancer cells, as a tumour imaging agent. This project has the potential to dramatically enhance patient survival as a result of improving treatments for cancer.
Genetic And Environmental Determinants Of Brain Networks In Ageing
Funder
National Health and Medical Research Council
Summary
Is brain ageing genetically or environmentally determined, or an interaction of both? We will explore the influence of genes and the environment on brain connectivity during ageing by studying how the brain network relates to cognitive functions.
The Effect Of Anti-fibrinolytic Drugs On Blood-brain Barrier Integrity And The Immune Response In Traumatic Brain Injury
Funder
National Health and Medical Research Council
Funding Amount
$870,476.00
Summary
This project aims to determine how a well known anti-fibrinolytic drug can improve the immune response and reduced blood brain barrier disruption following traumatic brain injury. We will also be testing additional drugs we have developed as well as a novel drug delivery system that better targets drugs to the damaged brain.
Understanding The Human Hand In Grasping And How This Changes After Stroke
Funder
National Health and Medical Research Council
Funding Amount
$227,855.00
Summary
The hand allows remarkable feats of dexterity. But, paralysis of the hand severely limits daily activities and is common after stroke. We will determine key mechanisms that control the hand at the level of the brain and spinal cord. We will assess some limits that develop in the muscle itself. Stroke patients will be tested so that we can better understand the brain�s control of the hand and use this to enhance recovery of hand performance in those with impaired function.