Transgenerational Effects Of Male Obesity - Mechanisms And Interventions
Funder
National Health and Medical Research Council
Funding Amount
$829,143.00
Summary
Childhood obesity is associated with obesity in either parent, and obese children tend to become obese adults, forming an intergenerational cycle that promotes obesity. We have identified paternal obesity as an important novel target for intervention to stop the progression of the obesity epidemic. This project investigates supplementation of obese fathers with folate to prevent the adverse impact of paternal obesity on subsequent generations.
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Preparation and use of lignite-iron ore composite briquettes for ironmaking. Preparation and use of lignite-iron ore composite briquettes for ironmaking. This project aims to study the briquetting processes of fine powders, and the preparation and utilization of new brown coal (lignite)–iron ore composite briquettes in a blast furnace. Lignite is a low-cost and abundant resource, and could be used in an emerging carbon-iron ore composite briquette for low-cost ironmaking. This project will perfo ....Preparation and use of lignite-iron ore composite briquettes for ironmaking. Preparation and use of lignite-iron ore composite briquettes for ironmaking. This project aims to study the briquetting processes of fine powders, and the preparation and utilization of new brown coal (lignite)–iron ore composite briquettes in a blast furnace. Lignite is a low-cost and abundant resource, and could be used in an emerging carbon-iron ore composite briquette for low-cost ironmaking. This project will perform multi-scale numerical studies, supported by lab/industry-scale experiments, to produce models and control strategies. Anticipated outcomes include better design and control of briquette's preparation and utilization in ironmaking for further cost-cutting; a new market for brown coal; and a more competitive Australian economy.Read moreRead less
Multiscale study of raceway operations for low-cost and stable ironmaking. This project aims to optimise blast furnace operations and to assess the performance of Australian brown coals in ironmaking. Pulverised coal injection is a cost-effective technology in blast furnace ironmaking, particularly if low-grade coal is used. This project aims to develop control strategies for stable and low-cost operation and to assess and optimise the combustion of brown coal and its blends in this process. The ....Multiscale study of raceway operations for low-cost and stable ironmaking. This project aims to optimise blast furnace operations and to assess the performance of Australian brown coals in ironmaking. Pulverised coal injection is a cost-effective technology in blast furnace ironmaking, particularly if low-grade coal is used. This project aims to develop control strategies for stable and low-cost operation and to assess and optimise the combustion of brown coal and its blends in this process. The project aims will be achieved via multiscale modelling and simulation, supported by laboratory and plant experiments. The outcomes of the project are intended to open a new market for brown coal.Read moreRead less
Numerical and experimental studies of the gas-particle flow and dust collection in electrostatic precipitation systems. This project will generate an integrated computer model to describe the gas-solid flow and dust collection in an ElectroStatic Precipitator (ESP). The model can be used to aid the design and control of ESP systems which are widely used for dust collection, leading to more competitive energy and related industries.