To Determine Whether Myc-driven Transformation In Haematopoietic Cell Lineages Is Dependent On High-levels Of Myc Protein Expression.
Funder
National Health and Medical Research Council
Funding Amount
$371,896.00
Summary
Myc is an essential cellular protein but is also a common drive of cancer in multiple tissues. In blood cancers Myc is frequently overexpressed. In contrast, Myc is rarely overexpressed in early stage solid cancers, although often elevated levels at later stages. We will employ unique models of cancer in which Myc can be activated at different set levels at different times during blood cell development to address what the specific contributions of different levels of Myc are in the evolution of ....Myc is an essential cellular protein but is also a common drive of cancer in multiple tissues. In blood cancers Myc is frequently overexpressed. In contrast, Myc is rarely overexpressed in early stage solid cancers, although often elevated levels at later stages. We will employ unique models of cancer in which Myc can be activated at different set levels at different times during blood cell development to address what the specific contributions of different levels of Myc are in the evolution of blood cancers.Read moreRead less
Molecular Characterisation Of Serous Ovarian Cancer With Poor Clinical Outcome
Funder
National Health and Medical Research Council
Funding Amount
$532,136.00
Summary
Ovarian cancer is the 5th most common cancer in women, and most lethal gynaecologic malignancy. Despite aggressive surgery and multi-drug chemotherapy the majority of women experience recurrence and ~70% will succumb to the disease. This project will investigate two molecular subtypes of ovarian cancer previously identified by our laboratory to better understand mechanisms associated with poor treatment response.