Identifying And Exploiting Novel Pharmacological Targets For Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Breast cancers are made up of different types of cancer cells, and not all cells contribute equally. A subset of cancer cells may be uniquely capable of driving tumor growth, rebuilding fatal tumors after therapy and establishing new tumors at distant sites. Identifying and exploiting the pathways that regulate the activity and survival of these cells will lead to better modes of treatment, and move towards a relapse-free future for breast cancer patients.
Next-generation ocean current forecasting to improve maritime safety . This project aims to measure upper ocean currents at scales of 10-100 km in Australia's marine estate using pioneering satellite radar technology. The Surface Water and Ocean Topography (SWOT) mission will map currents at 10 times the resolution of present-day satellites and revolutionise our understanding of ocean dynamics. Expected outcomes include validation of SWOT data in Australian waters and merging this data into Bure ....Next-generation ocean current forecasting to improve maritime safety . This project aims to measure upper ocean currents at scales of 10-100 km in Australia's marine estate using pioneering satellite radar technology. The Surface Water and Ocean Topography (SWOT) mission will map currents at 10 times the resolution of present-day satellites and revolutionise our understanding of ocean dynamics. Expected outcomes include validation of SWOT data in Australian waters and merging this data into Bureau of Meteorology ocean models. Downstream benefits include improved ocean forecasts for maritime safety, search-and-rescue, spill modelling, and marine conservation. At the same time, the project will build sovereign capability in emerging remote sensing technology with a legacy beyond the life of the SWOT mission.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560930
Funder
Australian Research Council
Funding Amount
$167,777.00
Summary
Airborne laser scanning for advanced environmental monitoring. This proposal seeks to enhance the national capability for airborne remote sensing of key environmental variables through the acquisition of an airborne laser scanner and inertial navigation system. Many environmental science studies, such as hydrology, soil moisture scaling and salinity, can be significantly enhanced by airborne laser scanning, through the creation of high precision, high resolution digital terrain models. Airborne ....Airborne laser scanning for advanced environmental monitoring. This proposal seeks to enhance the national capability for airborne remote sensing of key environmental variables through the acquisition of an airborne laser scanner and inertial navigation system. Many environmental science studies, such as hydrology, soil moisture scaling and salinity, can be significantly enhanced by airborne laser scanning, through the creation of high precision, high resolution digital terrain models. Airborne laser scanning can also measure three dimensional vegetation canopy structure, a useful indicator of biomass, carbon storage and vegetation health. This infrastructure will provide Australian researchers with a unique arsenal of remote sensing tools for advanced yet affordable environmental research studies.Read moreRead less
Generation of Digital Elevation Models by Fusion of Image and Terrain Laser Scan Data. There are currently two separate approaches to obtaining digital elevation models of the terrain surface by remote sensing, image based methods using aerial or satellite images and scanner techniques by terrain laser scanners. Each method provides elevations with high accuracy, but both require significant input from an operator during processing. It is proposed to take advantage of the synegies of these two ....Generation of Digital Elevation Models by Fusion of Image and Terrain Laser Scan Data. There are currently two separate approaches to obtaining digital elevation models of the terrain surface by remote sensing, image based methods using aerial or satellite images and scanner techniques by terrain laser scanners. Each method provides elevations with high accuracy, but both require significant input from an operator during processing. It is proposed to take advantage of the synegies of these two forms of data by combining the processing into a single solution for elevation determination by data fusion. This approach will improve the quality and efficiency of elevation determination.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.
An Integrated Ground Deformation Monitoring System Based on the Integration of InSAR, GPS and GIS Technologies. Interferometric Synthetic Aperture Radar (InSAR) can be used to monitor ground deformation at high spatial resolution. When integrated with Global Positioning Systems (GPS) so that atmospheric disturbance in InSAR result can be corrected, deformation can be resolved at sub-centimetre accuracy. The corrected InSAR result can be exported as a data layer into Geographic Information System ....An Integrated Ground Deformation Monitoring System Based on the Integration of InSAR, GPS and GIS Technologies. Interferometric Synthetic Aperture Radar (InSAR) can be used to monitor ground deformation at high spatial resolution. When integrated with Global Positioning Systems (GPS) so that atmospheric disturbance in InSAR result can be corrected, deformation can be resolved at sub-centimetre accuracy. The corrected InSAR result can be exported as a data layer into Geographic Information Systems (GIS) for further analysis. In collaboration with Hong Kong Polytechnic University researchers, the integrated InSAR-GPS-GIS system will be tested in both Hong Kong and Australia. The expected outcomes include a suite of algorithms and software tools capable of operational, cost-effective ground deformation monitoring.Read moreRead less
EPITHELIAL ION TRANSPORT DEFECTS IN CYSTIC FIBROSIS: PATHOPHYSIOLOGY AND TREATMENT
Funder
National Health and Medical Research Council
Funding Amount
$290,440.00
Summary
The thin layer of fluid covering the surface of the air passages acts to protect the airway surface from drying. This fluid also allows the hair-like projections, or cilia, on the top of the airway cells to beat more effectively. The volume and composition of this fluid is determined by the movement of salt and water across the mucous membranes of the air passages. The importance of this fluid is shown by the problems that occur in Cystic Fibrosis (CF), the most common lethal inherited disease a ....The thin layer of fluid covering the surface of the air passages acts to protect the airway surface from drying. This fluid also allows the hair-like projections, or cilia, on the top of the airway cells to beat more effectively. The volume and composition of this fluid is determined by the movement of salt and water across the mucous membranes of the air passages. The importance of this fluid is shown by the problems that occur in Cystic Fibrosis (CF), the most common lethal inherited disease affecting Australians. In CF, altered salt transport causes drying of the airway surface which impairs the working of the cilia. This leads to retention of mucous in the airway with repeated bacterial infections damaging the lungs. Simple tests have been designed to directly measure the movement of salt across the surface of the nasal passage using a fine soft rubber tube. Movement of mucous in the nose is measured using other simple techniques that are currently used diagnostically. Together, these tests in the nose provide vital information about how the surface of normal human airway moves salt, water and mucous. Any differences found in CF patients will then give us a good idea of the problems found in the CF lung. We will study the interactions between calcium, sodium and chloride in the fluid lining the airways, measuring changes in salt and mucous movement. A range of testing procedures will be used in human volunteers, anaesthetised mice and isolated tissues from sheep. We have already demonstrated important links between the fluid lining the airways and salt movement, and we expect that this may lead to the development of new treatments for Cystic Fibrosis. This therapy will focus on treating the lung problems of CF patients, the major cause of disability. We anticipate that this preventative therapy may offer real benefits in the fight to cure CF.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560920
Funder
Australian Research Council
Funding Amount
$129,800.00
Summary
Field spectroradiometer and associated equipment for quantitative measurement and characterization of biophysical features and calibration of remotely sensed imagery. This set of equipment will improve and extend existing research capabilities in the field of in-situ remote sensing research and applications, for both aquatic and terrestrial environments. It will contribute to knowledge regarding terrestrial, coastal and estuarine vegetation and linkages to environmental change and will assist in ....Field spectroradiometer and associated equipment for quantitative measurement and characterization of biophysical features and calibration of remotely sensed imagery. This set of equipment will improve and extend existing research capabilities in the field of in-situ remote sensing research and applications, for both aquatic and terrestrial environments. It will contribute to knowledge regarding terrestrial, coastal and estuarine vegetation and linkages to environmental change and will assist in the development of new algorithms, indices and techniques of vegetation discrimination from remotely sensed imagery. It will help in the understanding of reflectance in plants under stress or pest damage. The spectroradiometer will enable the group to expand applications in the field of urban fire hazard mapping, precision agriculture, crop physiology, species mapping, viticulture and canopy modelling.Read moreRead less