Identifying And Exploiting Novel Pharmacological Targets For Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$431,000.00
Summary
Breast cancers are made up of different types of cancer cells, and not all cells contribute equally. A subset of cancer cells may be uniquely capable of driving tumor growth, rebuilding fatal tumors after therapy and establishing new tumors at distant sites. Identifying and exploiting the pathways that regulate the activity and survival of these cells will lead to better modes of treatment, and move towards a relapse-free future for breast cancer patients.
Next-generation ocean current forecasting to improve maritime safety . This project aims to measure upper ocean currents at scales of 10-100 km in Australia's marine estate using pioneering satellite radar technology. The Surface Water and Ocean Topography (SWOT) mission will map currents at 10 times the resolution of present-day satellites and revolutionise our understanding of ocean dynamics. Expected outcomes include validation of SWOT data in Australian waters and merging this data into Bure ....Next-generation ocean current forecasting to improve maritime safety . This project aims to measure upper ocean currents at scales of 10-100 km in Australia's marine estate using pioneering satellite radar technology. The Surface Water and Ocean Topography (SWOT) mission will map currents at 10 times the resolution of present-day satellites and revolutionise our understanding of ocean dynamics. Expected outcomes include validation of SWOT data in Australian waters and merging this data into Bureau of Meteorology ocean models. Downstream benefits include improved ocean forecasts for maritime safety, search-and-rescue, spill modelling, and marine conservation. At the same time, the project will build sovereign capability in emerging remote sensing technology with a legacy beyond the life of the SWOT mission.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560930
Funder
Australian Research Council
Funding Amount
$167,777.00
Summary
Airborne laser scanning for advanced environmental monitoring. This proposal seeks to enhance the national capability for airborne remote sensing of key environmental variables through the acquisition of an airborne laser scanner and inertial navigation system. Many environmental science studies, such as hydrology, soil moisture scaling and salinity, can be significantly enhanced by airborne laser scanning, through the creation of high precision, high resolution digital terrain models. Airborne ....Airborne laser scanning for advanced environmental monitoring. This proposal seeks to enhance the national capability for airborne remote sensing of key environmental variables through the acquisition of an airborne laser scanner and inertial navigation system. Many environmental science studies, such as hydrology, soil moisture scaling and salinity, can be significantly enhanced by airborne laser scanning, through the creation of high precision, high resolution digital terrain models. Airborne laser scanning can also measure three dimensional vegetation canopy structure, a useful indicator of biomass, carbon storage and vegetation health. This infrastructure will provide Australian researchers with a unique arsenal of remote sensing tools for advanced yet affordable environmental research studies.Read moreRead less
Generation of Digital Elevation Models by Fusion of Image and Terrain Laser Scan Data. There are currently two separate approaches to obtaining digital elevation models of the terrain surface by remote sensing, image based methods using aerial or satellite images and scanner techniques by terrain laser scanners. Each method provides elevations with high accuracy, but both require significant input from an operator during processing. It is proposed to take advantage of the synegies of these two ....Generation of Digital Elevation Models by Fusion of Image and Terrain Laser Scan Data. There are currently two separate approaches to obtaining digital elevation models of the terrain surface by remote sensing, image based methods using aerial or satellite images and scanner techniques by terrain laser scanners. Each method provides elevations with high accuracy, but both require significant input from an operator during processing. It is proposed to take advantage of the synegies of these two forms of data by combining the processing into a single solution for elevation determination by data fusion. This approach will improve the quality and efficiency of elevation determination.Read moreRead less
Cognitive Enhancement In Schizophrenia Via Selective Oestrogen Receptor Modulator.
Funder
National Health and Medical Research Council
Funding Amount
$396,380.00
Summary
Cognitive dysfunction in schizophrenia is resistant to treatment and related to poor community functioning and quality of life. In spite of the widely appreciated magnitude of the problem, there is still a critical gap in our knowledge concerning treatments to reverse these cognitive deficits. The proposed research is significant because it will clarify the role of hormones and genes in relation to cognitive deficits in schizophrenia and it may help patients improve their level of functioning.
Molecular Mechanisms Of Receptor Activation And Signalling
Funder
National Health and Medical Research Council
Funding Amount
$571,980.00
Summary
Fundamental to our ability to respond to both immediate and long-term environmental changes and stresses is the coordinated regulation of cellular functions by hormonal and neurotransmitter stimuli. The great majority of such stimuli are sensed by G-protein coupled receptors (GPCR), complex glycoprotein molecules on the surface of most cells that selectively bind and are activated by various hormones and neurotransmitters. Although GPCRs are a superfamily of proteins that now compromise several ....Fundamental to our ability to respond to both immediate and long-term environmental changes and stresses is the coordinated regulation of cellular functions by hormonal and neurotransmitter stimuli. The great majority of such stimuli are sensed by G-protein coupled receptors (GPCR), complex glycoprotein molecules on the surface of most cells that selectively bind and are activated by various hormones and neurotransmitters. Although GPCRs are a superfamily of proteins that now compromise several hundred distinct but structurally-related members, the molecular mechanisms involved in their activation and, thus, their regulation of vital cellular functions, remains unclear. Based on insights that we have gained from the development and characterisation of several alpha1-adrenergic receptor mutants, we have developed a model of receptor activation. In this application we are proposing to further test and to extend the hypotheses underlying this model. Importantly, the functions regulated by GPCR include vital responses, such as the maintenance of circulatory homeostasis by augmenting heart pump function and by constricting vascular smooth muscle to maintain blood pressure. In addition, disordered cellular regulation by GPCR has been implicated in a wide variety of diseases, including hypertension, congestive heart failure and cardiac hypertrophy. Thus, the studies detailed here to further understand the molecular mechanisms of receptor activation have broad implications for our knowledge of critical physiological control systems, and may lead to novel therapeutic approaches to treat a variety of diseases.Read moreRead less
GABA(B) Receptor Modulation Of Gastrointestinal Function In Health And Disease By Alpha-Conotoxins
Funder
National Health and Medical Research Council
Funding Amount
$689,050.00
Summary
Chronic visceral pain is a common and debilitating condition arising from numerous diseases that affect our internal organs. There is a desperate need for more information about the mechanisms responsible for signalling chronic visceral pain to provide therapies and potentially find a cure for it. Our research focuses on ?-conotoxins (small peptides from marine cone snail venom) as novel potential therapeutic agents for the treatment of chronic visceral pain.