Development of a diagnostic microarray to detect aneuploidy in single cells. Chromosomal abnormalities account for about 10 per cent of all babies born with a defect. The risk of chromosomal abnormalities increases with maternal age and in patients with fertility problems. It has been estimated that 50 per cent of all embryos are aneuploid. Chromosomal aberrations also occur in the vast majority of tumours in humans. Accurate and rapid detection of chromosomal defects is an important health ser ....Development of a diagnostic microarray to detect aneuploidy in single cells. Chromosomal abnormalities account for about 10 per cent of all babies born with a defect. The risk of chromosomal abnormalities increases with maternal age and in patients with fertility problems. It has been estimated that 50 per cent of all embryos are aneuploid. Chromosomal aberrations also occur in the vast majority of tumours in humans. Accurate and rapid detection of chromosomal defects is an important health service delivered to the Australian public. This project aims to develop better tests for application in prenatal diagnostics including non-invasive testing of fetal cells from maternal circulation or cervical samples at 6-13 weeks gestation, IVF and cancer diagnostics.Read moreRead less
ARC Centre of Excellence in Plant Cell Wall Biology. The ARC Centre for Plant Cell Wall Biology will define the regulatory mechanisms that control molecular, enzymic and cellular processes involved in the synthesis, deposition, re-modelling and depolymerisation of cell wall polysaccharides of cereals and grasses. Plant cell walls represent the world's largest renewable carbon resource, but the regulatory mechanisms responsible for their synthesis and assembly are not understood. Key distinguishi ....ARC Centre of Excellence in Plant Cell Wall Biology. The ARC Centre for Plant Cell Wall Biology will define the regulatory mechanisms that control molecular, enzymic and cellular processes involved in the synthesis, deposition, re-modelling and depolymerisation of cell wall polysaccharides of cereals and grasses. Plant cell walls represent the world's largest renewable carbon resource, but the regulatory mechanisms responsible for their synthesis and assembly are not understood. Key distinguishing features of the Centre will be the international, integrative, and multidisciplinary approach towards addressing major questions in plant biology, its strategy to leverage ARC funding, and its linkages with potential national and international end-users of the fundamental scientific discoveries.Read moreRead less
Identification of Biological pathways regulated by circular RNAs. Circular RNAs (circRNAs) are a, recently discovered molecule. circRNAs are highly abundant and expressed in a tissue and disease specific manner. Yet, currently the understanding of how circRNAs regulate biological processes is very poor. This project aims to use pooled shRNA libraries to screen a large panel of cell lines and systematically identify cellular activities that are regulated by circRNAs. The expected outcome of this ....Identification of Biological pathways regulated by circular RNAs. Circular RNAs (circRNAs) are a, recently discovered molecule. circRNAs are highly abundant and expressed in a tissue and disease specific manner. Yet, currently the understanding of how circRNAs regulate biological processes is very poor. This project aims to use pooled shRNA libraries to screen a large panel of cell lines and systematically identify cellular activities that are regulated by circRNAs. The expected outcome of this study will be a catalogue of functionally active circRNAs. Over the past decades, the wealth of knowledge on the function of linear mRNAs has had a significant impact on medicine and agriculture. Similarly understanding how circRNAs regulate cellular activities may have an analogous impact on humans.Read moreRead less
Defining pathways that establish and maintain reproductive cell identity in plant ovules and seeds. Unlike animals, individual somatic cells in plants have the remarkable ability to regenerate into new plants, depending on the signals they perceive. This developmental plasticity is particularly important during normal plant growth, when mature cells adopt new identities within multicellular environments. Tissue complexity is critical for the utilisation of plants in society as food, fuel and fib ....Defining pathways that establish and maintain reproductive cell identity in plant ovules and seeds. Unlike animals, individual somatic cells in plants have the remarkable ability to regenerate into new plants, depending on the signals they perceive. This developmental plasticity is particularly important during normal plant growth, when mature cells adopt new identities within multicellular environments. Tissue complexity is critical for the utilisation of plants in society as food, fuel and fibre, but how and why plant cells adopt or change identity has been difficult to determine. This project aims to employ next-generation molecular methods to identify pathways driving differentiation of specific ovule and seed cell-types, which directly impact crop quality, yield and end-use.Read moreRead less
HEN1 is a regulator of piRNA metabolism, transcriptional regulation and mammalian male fertility. This project is to define the biochemistry of a previously uncharacterized protein in male fertility using a unique mouse model and innovative DNA and protein technologies. This project will define a novel, and essential, pathway for male fertility and may ultimately have relevance to the maintenance of health or improving fertility.
Discovery Early Career Researcher Award - Grant ID: DE230100377
Funder
Australian Research Council
Funding Amount
$423,659.00
Summary
Facilitating control of Queensland fruit fly and other insect pests. This project aims to address the need for a Queensland fruit fly male-only sterile release strain for the national Sterile Insect Technique program to control this devastating Australian horticulture pest. By combining two molecular technologies in a new strain that responds to temperature cues to trigger development of only male flies, this project expects to produce twice as many sterile males for release to mate with wild fe ....Facilitating control of Queensland fruit fly and other insect pests. This project aims to address the need for a Queensland fruit fly male-only sterile release strain for the national Sterile Insect Technique program to control this devastating Australian horticulture pest. By combining two molecular technologies in a new strain that responds to temperature cues to trigger development of only male flies, this project expects to produce twice as many sterile males for release to mate with wild females in fruit fly outbreak areas, preventing production of the next generation. Expected outcomes include significant reduction in production costs and increased efficiency of the national sterile release program, facilitating control of this damaging pest to protect Australia's billion dollar horticultural industry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100234
Funder
Australian Research Council
Funding Amount
$430,000.00
Summary
Enhancement of South Australian high-performance computing facilities. These facilities will enable the efficient use of high-performance computing and will more than double the capability provided by eResearch SA for South Australian researchers. They will support large-scale applications, running over many processors in parallel (high-performance computing) or large numbers of single processors (high-throughput computing).