Next generation dengue diagnostics. The 2009 dengue epidemic was widespread and the largest in North Queensland for 50 years. The outbreak was not quickly contained despite an extensive education program and a mosquito control taskforce. All four types of Dengue were detected, greatly increasing the chance of more severe complications such as Dengue haemorrhagic fever and Dengue shock syndrome. This project will improve our knowledge of Dengue proteins used in tests to diagnose the virus. The ne ....Next generation dengue diagnostics. The 2009 dengue epidemic was widespread and the largest in North Queensland for 50 years. The outbreak was not quickly contained despite an extensive education program and a mosquito control taskforce. All four types of Dengue were detected, greatly increasing the chance of more severe complications such as Dengue haemorrhagic fever and Dengue shock syndrome. This project will improve our knowledge of Dengue proteins used in tests to diagnose the virus. The new knowledge will be used to develop an easy to use test to diagnose Dengue infection early, rapidly and accurately. Effective diagnosis of Dengue will then allow timely implementation of intervention strategies (mosquito control, public advice, isolation and care).Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100149
Funder
Australian Research Council
Funding Amount
$590,000.00
Summary
Reaching new heights in high-resolution electron microscopy . High-resolution electron microscopy (EM): Direct electron detection cameras are a recent technological breakthrough delivering one of the greatest single advancements to the field of molecular cryo-EM. The aim of this project is to enable a 'first of a kind' cryo-EM platform in Australia enabling high-throughput atomic resolution protein structure determination. This will be achieved by integrating a state-of-the-art Gatan K2 Summit D ....Reaching new heights in high-resolution electron microscopy . High-resolution electron microscopy (EM): Direct electron detection cameras are a recent technological breakthrough delivering one of the greatest single advancements to the field of molecular cryo-EM. The aim of this project is to enable a 'first of a kind' cryo-EM platform in Australia enabling high-throughput atomic resolution protein structure determination. This will be achieved by integrating a state-of-the-art Gatan K2 Summit Direct Electron Detection camera system into the established cryo-EM facility managed by the University of Queensland node of the Australian Microscopy and Microanalysis Facility. This will offer unique and significantly improved capabilities for atomic resolution protein structure analysis, and will support a broad range of projects across the biological sciences.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100172
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Comprehensive cell imaging facility. This facility will provide Australian biological science researchers with equipment for in-depth analyses of cell function in vitro and in vivo. It will enable innovative research targeted at important questions in fields including cancer, immunology, stem cell biology, infectious disease and tissue regeneration.