Women Consider Retirement: A Critical Investigation of Attitudes Towards Work, Ageing and Retirement in Three Generations of Australian Women. The broad aim of this project is to investigate what work and retirement mean for women as they age and to consider the implications of these attitudes, intentions and experiences for government policy, especially given current concerns about workforce maintenance in view of population ageing.
The project will:
- develop a comprehensive understanding ....Women Consider Retirement: A Critical Investigation of Attitudes Towards Work, Ageing and Retirement in Three Generations of Australian Women. The broad aim of this project is to investigate what work and retirement mean for women as they age and to consider the implications of these attitudes, intentions and experiences for government policy, especially given current concerns about workforce maintenance in view of population ageing.
The project will:
- develop a comprehensive understanding of the characteristics, attitudes and experiences of three generations of women in relation to work, ageing and retirement
- examine the extent and consequences of generational and geographic differences in attitudes and choices
- explore the complex social and cultural factors shaping these attitudes, choices and consequences.
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Air pollution: do modern statistical model selection techniques make the silent killer speak too loud? Air pollution is estimated to cause 2400 deaths annually in Australia with an associated cost to the community of $17.2 billion. The outcomes of this project will enable an improved understanding of the association between air pollution and mortality in Australia, thereby allowing government, public health authorities, and regulatory agencies to implement better air pollution standards and pro ....Air pollution: do modern statistical model selection techniques make the silent killer speak too loud? Air pollution is estimated to cause 2400 deaths annually in Australia with an associated cost to the community of $17.2 billion. The outcomes of this project will enable an improved understanding of the association between air pollution and mortality in Australia, thereby allowing government, public health authorities, and regulatory agencies to implement better air pollution standards and provide more informed advice to the public on the necessity of avoiding exposure to air pollutants. These two outcomes are particularly important given Australia's ageing population and the fact that the elderly are among those most susceptible to harm from air pollution exposure.Read moreRead less
Understanding personal, social and environmental influences on nutrition and physical activity among older adults living in urban and rural areas. There are negative impacts of obesity, poor diet and physical inactivity on physical, psychological and social wellbeing and national economic costs associated with these burdens are substantial. Obesity and its associated illnesses are estimated to cost Australian health services $1.2 billion a year. An understanding of the modifiable determinants of ....Understanding personal, social and environmental influences on nutrition and physical activity among older adults living in urban and rural areas. There are negative impacts of obesity, poor diet and physical inactivity on physical, psychological and social wellbeing and national economic costs associated with these burdens are substantial. Obesity and its associated illnesses are estimated to cost Australian health services $1.2 billion a year. An understanding of the modifiable determinants of nutrition and physical activity behaviours is required in order to develop effective interventions to promote health and well-being. Promoting physical activity and a healthy diet thus has the potential to substantially reduce the burden of disease in Australia and improve quality of life.Read moreRead less
Adaptive capabilities in the elderly during extreme heat events in South Australia. This study, using first hand accounts of experiences and perceptions of the extreme heat event of 2009 in South Australia, will provide a valuable insight into the heat adaptive capability of the ageing population, factors affecting susceptibility, and ways to curb the predicted increase in often life-threatening heat exacerbated illnesses, many of which require extended hospital stays. It is envisaged that findi ....Adaptive capabilities in the elderly during extreme heat events in South Australia. This study, using first hand accounts of experiences and perceptions of the extreme heat event of 2009 in South Australia, will provide a valuable insight into the heat adaptive capability of the ageing population, factors affecting susceptibility, and ways to curb the predicted increase in often life-threatening heat exacerbated illnesses, many of which require extended hospital stays. It is envisaged that findings will help inform health policy and contribute to the formulation of a National Heatwave Response plan. Study findings will be disseminated widely at government (state and federal), non-government, and community levels and will help to raise the awareness of heat exacerbated illness in general.Read moreRead less
Identification of genes regulating breast cancer progression and metastasis. Breast cancer is the most common cause of cancer-related death in women in Australia. Although the treatments have improved over the last thirty years, many women still die from relapse of the disease. Our goal is to identify genes involved in the regulation of breast cancer progression and metastasis. This may lead to the discovery of druggable molecules for better targeted therapies for patients.
Identifying mitogenic signalling proteins with phosphatidyl inositol lipids. Health care of an ageing population is a national priority of the community. In order to understand the factors that control cell growth and death in cancer cells signalling proteins can be identified and studied and compared with model systems from quiescent cells. Using phospholipids attached to 'fishing lines' we can search for, identify and study the function of all the downstream signalling proteins in activated c ....Identifying mitogenic signalling proteins with phosphatidyl inositol lipids. Health care of an ageing population is a national priority of the community. In order to understand the factors that control cell growth and death in cancer cells signalling proteins can be identified and studied and compared with model systems from quiescent cells. Using phospholipids attached to 'fishing lines' we can search for, identify and study the function of all the downstream signalling proteins in activated cancer cells. This will provide the basic information for drug discovery processes to target specific molecules that inhibit and control the function of the signalling proteins implicated in the growth of cancer cells.Read moreRead less
Regulation of cell surface sialylation by targeting the CMP-sialic acid transporter and sialyltransferase: Towards the development of anti-metastatic agents. The mortality rates for many of the cancers afflicting the world's population are mirrored in Australia, particularly colon cancer. It's generally accepted that colon cancer, and cancers as a whole, are a significant healthcare issue in this country, representing a major challenge to biomedical researchers and healthcare professional. The e ....Regulation of cell surface sialylation by targeting the CMP-sialic acid transporter and sialyltransferase: Towards the development of anti-metastatic agents. The mortality rates for many of the cancers afflicting the world's population are mirrored in Australia, particularly colon cancer. It's generally accepted that colon cancer, and cancers as a whole, are a significant healthcare issue in this country, representing a major challenge to biomedical researchers and healthcare professional. The economic and social impact is immense, placing a huge strain on the healthcare system, as well as on the families affected. Any alternative treatment reducing cancer metastasis would be of enormous national and international benefit. It's believed that the significant studies outlined in this proposal, which are based on exciting preliminary data, will make a sizeable contribution to achieving this goal.Read moreRead less
Synthesis of phosphatidylinositol and inositol polyphosphate derivatives to probe key signalling proteins associated with cell growth and cancer. Health care of an ageing population is a national priority of the community. In order to understand the factors that control cell growth and death in cancer cells signalling proteins can be identified and studied and compared with model systems from quiescent cells. Using phospholipids and inositol polyphosphates attached to 'fishing lines' we can sea ....Synthesis of phosphatidylinositol and inositol polyphosphate derivatives to probe key signalling proteins associated with cell growth and cancer. Health care of an ageing population is a national priority of the community. In order to understand the factors that control cell growth and death in cancer cells signalling proteins can be identified and studied and compared with model systems from quiescent cells. Using phospholipids and inositol polyphosphates attached to 'fishing lines' we can search for, identify and study the function of many of the downstream signalling proteins in activated cancer cells. This will provide the basic information for discovery processes to target specific molecules that inhibit and control the function of the signalling proteins implicated in the growth of cancer cells.Read moreRead less
Do pancreatic stellate cells play a role in pancreatic exocrine secretion? 3 major national benefits: 1)Alignment with research priority goals of preventative health care and ageing well ageing productively. Elucidation of mechanisms of action of CCK and the interaction of PSCs and acinar cells in mediating pancreatic secretion will help refine our approach to the prevention and treatment of disorders related to the above processes viz. maldigestion, malabsorption, obesity and pancreatic cancer. ....Do pancreatic stellate cells play a role in pancreatic exocrine secretion? 3 major national benefits: 1)Alignment with research priority goals of preventative health care and ageing well ageing productively. Elucidation of mechanisms of action of CCK and the interaction of PSCs and acinar cells in mediating pancreatic secretion will help refine our approach to the prevention and treatment of disorders related to the above processes viz. maldigestion, malabsorption, obesity and pancreatic cancer. 2)Enhancement of Australia's reputation in gastrointestinal (GI) research through a unique collaboration between internationally recognised researchers in GI and pancreatic biology. 3)Training opportunities for Australian research students and scientists in physiology, gastroenterology and pancreatology.Read moreRead less
Characterisation of molecular regulation of telomerase and telomeres by p53 in cell ageing. Telomeres, the ends of chromosomes shorten as a function of cell division, and thereby limit cell lifespan. Telomerase synthesizes telomeres and thus renders cells immortal. Recently, we found that p53, a protein with an important role in cell aging and in the uncontrolled growth of cancer, interacts with telomeres and telomerase by binding to the telomere proteins TRF1 and TRF2. This project will deciphe ....Characterisation of molecular regulation of telomerase and telomeres by p53 in cell ageing. Telomeres, the ends of chromosomes shorten as a function of cell division, and thereby limit cell lifespan. Telomerase synthesizes telomeres and thus renders cells immortal. Recently, we found that p53, a protein with an important role in cell aging and in the uncontrolled growth of cancer, interacts with telomeres and telomerase by binding to the telomere proteins TRF1 and TRF2. This project will decipher the mechanisms by which p53 regulates telomerase and telomeres, and establish the interrelationship of these proteins in regulating cell lifespan, death and immortalisation. It will provide important information for molecular intervention in cell ageing and immortalisation.Read moreRead less