To implement and evaluate flexible models of palliative care service delivery for terminally ill people living alone at home. Provision of evaluated services for this growing population group will lead to better planning and implementation of care being delivered at home, improved quality of life, increased capacity to die at home, and a reduction in hospitalisations and other health care costs.
Imaging Mass Spectrometry (IMS), a peptide biomarker discovery tool using tissue. Cancer is the second most common cause of death in Australia. The newly developed technology of Imaging Mass Spectrometry for peptides in tissue has the potential to discover biomarkers for early diagnosis of cancer. This new technology could avoid a number of cancer deaths and reduce suffering of patients through earlier and better diagnosis.
Everyday Heritage. This project aims to uncover everyday but overlooked forms of Australian heritage. Working collaboratively to bridge academic and industry practice, it seeks to develop innovative methods with outcomes expected to include enhanced collaboration between heritage, digital humanities, and historical research, and new resources for communities and the heritage sector. This should provide significant social and cultural benefits such as more inclusive forms of heritage, and broader ....Everyday Heritage. This project aims to uncover everyday but overlooked forms of Australian heritage. Working collaboratively to bridge academic and industry practice, it seeks to develop innovative methods with outcomes expected to include enhanced collaboration between heritage, digital humanities, and historical research, and new resources for communities and the heritage sector. This should provide significant social and cultural benefits such as more inclusive forms of heritage, and broader intellectual and practical understandings of shared history and citizenship. The project will promote public debate on the role of the past in modern Australia through a range of new forms of history and heritage, digital resources and heritage management tools.
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Oceanic Conditions within Extreme Tropical Cyclones. Australia's tropical and subtropical areas include major infrastructure projects such as the North West shelf oil and gas projects, major mining operations, export ports, natural environments such as the Great Barrier Reef and major tourism industries. All these industries are crucially impacted by extreme tropical cyclones. Despite the importance of these systems, our present understanding of tropical cyclones is incomplete. This project will ....Oceanic Conditions within Extreme Tropical Cyclones. Australia's tropical and subtropical areas include major infrastructure projects such as the North West shelf oil and gas projects, major mining operations, export ports, natural environments such as the Great Barrier Reef and major tourism industries. All these industries are crucially impacted by extreme tropical cyclones. Despite the importance of these systems, our present understanding of tropical cyclones is incomplete. This project will significantly enhance our ability to carry out accurate engineering design of critical offshore infrastructure, as well as marine forecasts in such environments. As such, the project will have major scientific, economic and social benefits for Australia.Read moreRead less
How critical is the inflammatory response in senile plaque formation in a mutant APP transgenic mouse model? The aims of this project is to examine the brains of mice genetically engineered to produce a human mutant form of insoluble beta amyloid protein known to play a critical role in the development of Alzheimer's disease (AD). If the "trigger" for AD is an inflammatory reaction, then the relevant examination of the early stages of senile plaque formation in these animals could lead to pharma ....How critical is the inflammatory response in senile plaque formation in a mutant APP transgenic mouse model? The aims of this project is to examine the brains of mice genetically engineered to produce a human mutant form of insoluble beta amyloid protein known to play a critical role in the development of Alzheimer's disease (AD). If the "trigger" for AD is an inflammatory reaction, then the relevant examination of the early stages of senile plaque formation in these animals could lead to pharmaceutical intervention to delay the development of this debilitating disease. A 5 year delay would significantly reduce the number of people with AD, not only adding years of improved quality of life, but also saving hundreds of millions of Australian dollars in health costs.Read moreRead less
Designing a Holistic Model of Advice to Improve Retirement Planning. We aim to improve retirement planning through the design and application of a new model integrating financial advice with career and health planning to optimise financial and psychological outcomes. We will test a multidisciplinary, holistic model of advice combining specialist knowledge in careers, health, and finances. Expected outcomes of the project include evaluating the use of a broader range of experts during retirement ....Designing a Holistic Model of Advice to Improve Retirement Planning. We aim to improve retirement planning through the design and application of a new model integrating financial advice with career and health planning to optimise financial and psychological outcomes. We will test a multidisciplinary, holistic model of advice combining specialist knowledge in careers, health, and finances. Expected outcomes of the project include evaluating the use of a broader range of experts during retirement planning and developing a model for the future training and development of financial advisers.By optimising the timing of workplace exit, we aim to decrease reliance on pensions and encourage earlier and on-going engagement in the retirement planning process. This will provide significant social and economic benefits.Read moreRead less
DEVELOPMENT OF NOVEL ENVIRONMENTALLY ACCEPTABLE DRILLING FLUIDS. An innovative technique of micro-emulsion of vegetable oils and water has been developed to create a new generation, low-toxicity drilling fluids for use by the petroleum exploration industry. The project aims at investigating the chronic toxicity of new generation drilling fluids to fish, and re-formulate the drilling fluids to minimize the toxic ingredients. Biomarkers of exposure and effects such as, but not limited to, EROD ind ....DEVELOPMENT OF NOVEL ENVIRONMENTALLY ACCEPTABLE DRILLING FLUIDS. An innovative technique of micro-emulsion of vegetable oils and water has been developed to create a new generation, low-toxicity drilling fluids for use by the petroleum exploration industry. The project aims at investigating the chronic toxicity of new generation drilling fluids to fish, and re-formulate the drilling fluids to minimize the toxic ingredients. Biomarkers of exposure and effects such as, but not limited to, EROD induction, DNA damage and stress proteins will be explored in fish exposed chronically to drilling fluids or their ingredients. Outcomes include environmentally acceptable drilling fluids, and will represent the start point for multi-million dollars agriculture and manufacturing industry in Australia.Read moreRead less
Investigating older Australians' beliefs about and understanding of mental health and their practice of relevant protective behaviours. Healthy ageing and mental health are acknowledged national priorities. This project will generate new knowledge relating to older Australians' mental health literacy and the motivators and barriers influencing their engagement in protective behaviours. The resulting communications strategy will provide tangible outcomes for the industry partners to utilise. The ....Investigating older Australians' beliefs about and understanding of mental health and their practice of relevant protective behaviours. Healthy ageing and mental health are acknowledged national priorities. This project will generate new knowledge relating to older Australians' mental health literacy and the motivators and barriers influencing their engagement in protective behaviours. The resulting communications strategy will provide tangible outcomes for the industry partners to utilise. The project will thus produce knowledge advancement and tools for practitioners, both of which will enhance public welfare and reduce long-term healthcare costs. While this project focuses on older Australians, those of all ages will benefit from a communications campaign that provides individuals with knowledge to protect and strengthen their mental health.Read moreRead less
Synthesis and Production of High Value Pyridines Combining the Concepts of Alternative Reaction Media and Process Intensification. This project aims to develop novel syntheses and process route for substituted pyridines by bringing together expertise in the fields of green chemistry and process intensification. Minimisation of waste, energy efficiency, and improved selectivity and control will be the key process and chemistry targets, which will produce high value compounds. Traditional approach ....Synthesis and Production of High Value Pyridines Combining the Concepts of Alternative Reaction Media and Process Intensification. This project aims to develop novel syntheses and process route for substituted pyridines by bringing together expertise in the fields of green chemistry and process intensification. Minimisation of waste, energy efficiency, and improved selectivity and control will be the key process and chemistry targets, which will produce high value compounds. Traditional approaches use organic solvents and preformed salts which are costly, generate waste and the processes are energy intensive due to poor selectivity, low yield and extensive separation steps. This is a generic investigation which will have wide ranging applications in the pharmaceutical, energy and advanced electronic industries.Read moreRead less
Application of process intensification on rotating surfaces (PIRS) in organic synthesis. Process intensification technologies in the form of SDP and RTP are new to Australia and present many opportunities for carrying out the synthesis of organic compounds. They have remarkable versatility in being able to control chemical reactions with greater selectivity than using classical batch technology, at the same time allowing access to new compounds. Moreover, the technologies embrace the principles ....Application of process intensification on rotating surfaces (PIRS) in organic synthesis. Process intensification technologies in the form of SDP and RTP are new to Australia and present many opportunities for carrying out the synthesis of organic compounds. They have remarkable versatility in being able to control chemical reactions with greater selectivity than using classical batch technology, at the same time allowing access to new compounds. Moreover, the technologies embrace the principles of green chemistry in minimising the generation of waste, while operating under continuous flow which is destined to be more attractive to industry. This is likely in the fine chemicals sector, and in drug discovery. The project will provide first-rate research training and promote Australian science. Read moreRead less