Effect Of Cross-linking Cytokines To Natural And Synthetic Matrices On Post-implantation Fibrosis In Animal Models
Funder
National Health and Medical Research Council
Funding Amount
$77,154.00
Summary
My research will focus on the development and in vivo testing of cytokine cross-linked surgical implant materials in selected mouse and rat models. We hypothesise that Follistatin bound to heparin sulphate cross-linked natural and synthetic matrix implants will suppress the formation of Extra cellular matrix around the implant during wound healing in a mouse surgical model.
Retinal Endothelial Cell Changes That Precede Retinal Vein Occlusion And The Retinal Extracellular Space Changes That Follow It
Funder
National Health and Medical Research Council
Funding Amount
$118,121.00
Summary
Dr. Min Hye Kang, at The University of Western Australia, is investigating microscopic blood vessel changes that precede the onset of devastating blindness. She is also studying functional changes that occur in the retina following deprivation of its blood supply. Her research has significantly improved our understanding of cellular mechanisms that lead to blindness. It has also aided in the development of new treatment strategies for the prevention of vision loss.
Does Statin Use Have A Disease Modifying Effect In Symptomatic Knee Osteoarthritis?
Funder
National Health and Medical Research Council
Funding Amount
$133,194.00
Summary
Osteoarthritis (OA) is a major cause of knee pain and disability. Treatments are limited to reducing pain and improving function: no therapy slows disease progression, with symptomatic end-stage OA treated by knee replacement. Statins, a drug class used to lower cholesterol levels, may affect the structural progression in knee OA. We propose a randomised controlled trial to see if statin use slows the progression of knee OA, which would delay or prevent the need for joint replacement.
Collagen II Mutations And The Unfolded Protein Response In Inherited Cartilage Disease
Funder
National Health and Medical Research Council
Funding Amount
$92,314.00
Summary
In genetic diseases, gene mutations commonly cause proteins to fold abnormally. This can cause cell stress resulting in cell death. My studies will determine the role of cell stress in a clinically important group of diseases, caused by cartilage collagen mutations, that result in abnormal development of the skeleton. These studies will define the mechanisms of how cell stress causes these disorders; knowledge that will underpin the development of new therapeutic strategies