Identifying The Critical Pathways Which Regulate Vertebrate Craniofacial Development
Funder
National Health and Medical Research Council
Funding Amount
$552,131.00
Summary
Understanding the genes which underlie human birth defects is of immense clinical importance. Our laboratory is a world-leader investigating a gene responsible for facial skeleton development, Grhl2. With our wide range of models, we will discover how Grhl2 works to ensure the face and skull develop properly during birth.
Understanding The Causes Of Childhood Congenital Anomalies Of The Kidney And Urinary Tract
Funder
National Health and Medical Research Council
Funding Amount
$609,748.00
Summary
Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified ....Congenital anomalies of the kidney and urinary tract (CAKUT) is a common cause of renal failure in children. The majority of patients with CAKUT do not know the underlying cause of their renal anomalies. In this proposal we will characterise the developmental events that are perturbed in three mouse models of CAKUT and identify the causal gene responsible in each mouse model. We will translate this information to the clinic by screening patients with CAKUT for mutations in these newly identified genes.Read moreRead less
Building Australia's next-generation ocean-sea ice model. Ocean and sea ice models are used for predicting future ocean and climate states, and for climate process research. This project aims to bring the next generation of ocean-sea ice models to Australia and configure the models for our local priorities. The ultimate goal is to create a new coupled ocean-sea ice model for Australia that includes surface waves and biogeochemistry. The model will be optimised and evaluated on Australian facilit ....Building Australia's next-generation ocean-sea ice model. Ocean and sea ice models are used for predicting future ocean and climate states, and for climate process research. This project aims to bring the next generation of ocean-sea ice models to Australia and configure the models for our local priorities. The ultimate goal is to create a new coupled ocean-sea ice model for Australia that includes surface waves and biogeochemistry. The model will be optimised and evaluated on Australian facilities, and released for community use. These developments underpin future ocean state forecasts, sea ice forecasts, wave forecasts, decadal climate prediction and climate process studies. The project will benefit search and rescue, Defence and shipping operations, and will enhance future climate projections.Read moreRead less
EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cel ....EFR3: Novel gatekeeper of cell proliferation. This interdisciplinary, cross-institutional project uses leading-edge mass spectrometry and the yeast genetic model to enhance knowledge of fundamental signalling mechanisms common to cell proliferation of eukaryotic cells. Building on extensive preliminary data that identifies novel energy-stress control points, this research will generate insights into critical and conserved features of nutrient stress control of cell proliferation that ensures cell survival. This project advances basic and applied biology. Its outcomes will be relevant to several research areas and industries, specifically to the propagation of cell cultures that nowadays contributes to the production of a myriad of biotechnical and pharmaceutical commodities.
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Population ageing, labour mobility and sustainability of China's economic growth - a dynamic general equilibrium analysis. China is Australia's second largest trading partner. This project will enable Australian policymakers and business partners to gain better understanding of China's macroeconomic performance between 2008 and 2030. Secondly, China is the second largest source of immigrants to Australia. Given that Australia's population is ageing and labour shortages are expected, Australia ma ....Population ageing, labour mobility and sustainability of China's economic growth - a dynamic general equilibrium analysis. China is Australia's second largest trading partner. This project will enable Australian policymakers and business partners to gain better understanding of China's macroeconomic performance between 2008 and 2030. Secondly, China is the second largest source of immigrants to Australia. Given that Australia's population is ageing and labour shortages are expected, Australia may benefit increasingly from the flow of Chinese immigrants. The project will provide Australian policymakers with detailed labour supply forecasts in China disaggregated by age, sex, sector and region that will enable them to develop targeted immigration policies and effectively harness the flow of Chinese emigrants to Australia.Read moreRead less
How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent si ....How do cells survive nutrient stress? Insight into mechanisms. This project studies cell survival under nutrient stress in eukaryotes. Building on extensive preliminary data that identifies novel TOR (Target of Rapamycin) Complex 2 (TORC2) control points it expects to generate new knowledge of critical and conserved features of stress control of macroautophagy that ensures cell survival. It uses interdisciplinary and innovative approaches to validate and characterize nutrient-stress dependent signaling. Expected outcomes include novel insights into environmental control of cell proliferation and forging cross institutional collaborations. This knowledge benefits basic and applied biology and is relevant to industries/projects utilizing living cells as nutrient supports cell survival and proliferation.Read moreRead less
New estimation and testing issues in nonlinear time series econometrics. The outcomes of this project will not only complement but also enhance the existing strengths of Australian researchers in the field of econometrics. The outcomes are also expected to help stabilise the national financial market for more accurate forecasts. It is also expected that the outcomes will provide novel models to respond to climate change and variability and to provide accurate warming estimates for improving the ....New estimation and testing issues in nonlinear time series econometrics. The outcomes of this project will not only complement but also enhance the existing strengths of Australian researchers in the field of econometrics. The outcomes are also expected to help stabilise the national financial market for more accurate forecasts. It is also expected that the outcomes will provide novel models to respond to climate change and variability and to provide accurate warming estimates for improving the policy making process.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100116
Funder
Australian Research Council
Funding Amount
$1,200,000.00
Summary
Facilities for Atmospheric Boundary Layer Evaluation and Testing. This proposal aims to establish state-of-the-art stationary and mobile facilities for atmospheric wind, dust and plume measurements with unique capability to quantify the effect of climate change, surface topography and urbanisation on near-surface microclimate where humans live. To better predict microclimate, mitigate air pollution impacts and exploit local conditions for improved urban planning and agricultural yield, high qual ....Facilities for Atmospheric Boundary Layer Evaluation and Testing. This proposal aims to establish state-of-the-art stationary and mobile facilities for atmospheric wind, dust and plume measurements with unique capability to quantify the effect of climate change, surface topography and urbanisation on near-surface microclimate where humans live. To better predict microclimate, mitigate air pollution impacts and exploit local conditions for improved urban planning and agricultural yield, high quality observations of the near-surface atmosphere at fine temporal and spatial resolutions are required. The proposed Facilities for Atmospheric Boundary Layer Evaluation and Testing (FABLET) will advance Australia’s capability to make these difficult measurements of atmospheric boundary layer.Read moreRead less
Mechanisms controlling enteroendocrine hormone secretion in human duodenum. This project aims to gain a deeper understanding of nutrient sensing pathways present in enteroendocrine cells within the human intestine. These cells control digestive function, blood glucose levels and food intake and are thus critical to digestion. This project will endeavour to be the first to assess the biology of human enteroendocrine cells and will use innovative approaches to deeply assess function from the level ....Mechanisms controlling enteroendocrine hormone secretion in human duodenum. This project aims to gain a deeper understanding of nutrient sensing pathways present in enteroendocrine cells within the human intestine. These cells control digestive function, blood glucose levels and food intake and are thus critical to digestion. This project will endeavour to be the first to assess the biology of human enteroendocrine cells and will use innovative approaches to deeply assess function from the level of the individual to isolated enteroendocrine cells.Read moreRead less
Empowering next-generation sea-ice models with wave–ice mathematics. Sea ice is a crucial part of the Australian and global climate systems, and the most sensitive indicator of the alarming climate changes in motion. This project aims to deliver a vital component in next-generation sea-ice models, by modelling ocean waves in the ice-covered ocean, and implementing it in the leading large-scale sea-ice model. The waves-in-ice model will be accurate for the range of possible wave–ice conditions, u ....Empowering next-generation sea-ice models with wave–ice mathematics. Sea ice is a crucial part of the Australian and global climate systems, and the most sensitive indicator of the alarming climate changes in motion. This project aims to deliver a vital component in next-generation sea-ice models, by modelling ocean waves in the ice-covered ocean, and implementing it in the leading large-scale sea-ice model. The waves-in-ice model will be accurate for the range of possible wave–ice conditions, using understanding derived from state-of-the-art experimental measurements. Powerful mathematical approximation methods will be developed to generate model efficiency. The outcomes will create a new standard in sea-ice modelling, with significant benefits for sea-ice forecasting and climate studies.Read moreRead less