Microenvironments which support extramedullary hematopoiesis. Tissue regeneration is a breakthrough technology absolutely dependent on knowledge of the stem cells and stromal cells which support differentiation and tissue development. This project investigates the stromal cell types in spleen which can regenerate blood-forming cells in an ectopic tissue site or artificial matrix.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100011
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
Integrated Multimodal System for Multiplexed Imaging of Signal Transduction. This project will introduce a unique microscopy platform and associated technologies into the Australian research environment that will enable researchers to redefine our understanding of molecular signal transduction. The instrumentation will enable the multidimensional imaging of live cells with unprecendented speed and sensitivity. The featured imaging modalities will enable the integration of distinct biological, ....Integrated Multimodal System for Multiplexed Imaging of Signal Transduction. This project will introduce a unique microscopy platform and associated technologies into the Australian research environment that will enable researchers to redefine our understanding of molecular signal transduction. The instrumentation will enable the multidimensional imaging of live cells with unprecendented speed and sensitivity. The featured imaging modalities will enable the integration of distinct biological, biochemical and chemical probes with a focus on minimizing phototoxicity. Expected outcomes include new fundamental knowledge on molecular signal transduction and cell heterogeneity; development of novel probes and methodologies and the development of new and existing interdisciplinary research collaborations. Read moreRead less
Mobility Shocks: Understanding disruptions to Australian migration. This Fellowship aims to generate new knowledge about the impacts of the Covid-19 pandemic on human migration and mobility, in order to advance understanding of major disruptive changes to population movement more broadly. Fellowship outcomes will include designing innovative geospatial research methods, linking and analysing cutting-edge datasets, and building cross-sector collaborations, in order to develop a new theory of ‘Mob ....Mobility Shocks: Understanding disruptions to Australian migration. This Fellowship aims to generate new knowledge about the impacts of the Covid-19 pandemic on human migration and mobility, in order to advance understanding of major disruptive changes to population movement more broadly. Fellowship outcomes will include designing innovative geospatial research methods, linking and analysing cutting-edge datasets, and building cross-sector collaborations, in order to develop a new theory of ‘Mobility Shocks’. This will benefit Australia and its migration partners with new ideas, tools, evidence and expertise to help scholars, policy makers and practitioners to understand, anticipate, and manage future disruptive changes to human migration and mobility in the Australian context and beyond.Read moreRead less
Gamete-specific knockout of Fizzy-Related to examine its meiotic role in oocytes and sperm. Fizzy-Related is a gene that appears to be essential in making an ovulated egg, and it may also have an important role to play in making sperm. A mouse knockout will be generated to examine exactly how it functions; because it affects the egg number remaining in the ovary and egg quality Fizzy-Related may be eventually an important therapeutic target.
The Role Of Melanoma Tumour Antigen P97 (Melanotransferrin) In Melanoma Tumourigenesis.
Funder
National Health and Medical Research Council
Funding Amount
$563,242.00
Summary
The Role of Melanoma Tumour Antigen p97 (Melanotransferrin) in Melanoma Tumourigenesis Melanotransferrin (MTf) is a homologue of the iron transport protein, transferrin, and was one of the first well characterised melanoma tumour antigens. Our published studies have shown that MTf plays an important role in melanoma tumourigenesis in vivo. In this proposal, we will assess if it is associated with melanoma progression in patient samples and examine its role in melanoma growth and metastasis.
Epigenetic reprogramming of development by nutritional factors in honeybee. The project aims to study the mechanism by which a specialised nutrition can change or even reverse the process of adult cell fate. The project will use a previously unexplored method of nutritional reprogramming of imaginal discs in honeybees by royal jelly and identify novel components of both the genetic and epigenetic systems that are most potent as reprogramming factors. The project seeks to improve our understandin ....Epigenetic reprogramming of development by nutritional factors in honeybee. The project aims to study the mechanism by which a specialised nutrition can change or even reverse the process of adult cell fate. The project will use a previously unexplored method of nutritional reprogramming of imaginal discs in honeybees by royal jelly and identify novel components of both the genetic and epigenetic systems that are most potent as reprogramming factors. The project seeks to improve our understanding of how epigenetic remodelling of the information content of the genome contributes to conversion of cell fate in vivo and in vitro. More broadly, the project could potentially establish the honeybee imaginal discs as a model for understanding pluripotency and environmentally controlled developmental plasticity.Read moreRead less
Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This k ....Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This knowledge will reveal how IPO5 controls formation of sperm by revealing what other proteins it binds to and how this affects cell signaling and responses to the environment.
Benefits: This will provide information about potential interventions to control fertility or to repair abnormal cells.
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Population Structure Of The Patagonian Toothfish, Dissostichus Eleginoides, In Australian Waters
Funder
Fisheries Research and Development Corporation
Funding Amount
$71,219.00
Summary
Resolution of stock structure of toothfish in Australian and other waters is required. Tagging experiments, while important, cannot by themselves give a complete picture of stock structure. If genetic differences between areas are detected, then the amount of gene flow between areas must be minimal and more than one stock can be assumed. However, if differences are not detected, then the hypothesis of a single genetic stock cannot be rejected. This hypothesis may be rejected if there is no evide ....Resolution of stock structure of toothfish in Australian and other waters is required. Tagging experiments, while important, cannot by themselves give a complete picture of stock structure. If genetic differences between areas are detected, then the amount of gene flow between areas must be minimal and more than one stock can be assumed. However, if differences are not detected, then the hypothesis of a single genetic stock cannot be rejected. This hypothesis may be rejected if there is no evidence from tagging experiments of fish movement between areas. Therefore, resolution of stock structure is better managed by a combination of tagging and genetic approaches than by either approach alone. Tagging experiments are under way; we propose to carry out the required genetic analyses, and then consider both sets of data jointly to define likely stock structures.
Genetic evidence already collected (based on small sample sizes from two areas of Macquarie), suggests that the amount of movement between fishing locations might be very limited. If this preliminary conclusion is substantiated by larger sample sizes, then careful management of the fishery will be needed, as depletion of one area is unlikely to be quickly replaced by immigration from another area.
The work proposed here will resolve this issue for Macquarie island, and will also determine whether there are separable substocks of toothfish around HIMI, and whether the HIMI stock(s) are separable from the Macquarie island stock(s). Importantly, if William's Ridge fish are identified as part of a straddling stock extending into Australia's EEZ (Heard Island), then they can be managed as though wholly part of Australia's EEZ (recent UNIA agreement).
These issues have to be resolved for effective and sustainable management of toothfish fisheries by Australian management (AFMA). The information gathered will also be relevant to the management authorities of other nations controlling toothfish fisheries.
Note: Recent meetings of CCAMLR (1998, 1999) have recognised the urgent requirement of further work on stock structure in D. eleginoides , particularly as initial genetic studies in other laboratories using isolectric focussing and allozyme analysis have reported inconsistent results (see Box 1 below). Objectives: 1. To use microsatellite variation to resolve the genetic connectivity of different spatial and temporal toothfish samples collected from Macquarie Island and Heard, McDonald Islands. 2. To compare genetic and tagging data from Macquarie and Heard, McDonald regions to maximise toothfish stock structure knowledge in these regions. 3. To report on the outputs from the research and the resultant management response. Read moreRead less
Transition to adulthood in greater Jakarta: A longitudinal perspective. Interviewing 3,000 young adult Indonesians at two points in time, this project examines whether their economic and social outcomes change across time or whether early experience determines longer-term outcomes. What are the factors involved in transition to adulthood among young people in a rapidly developing metropolis of a developing country?
A Study Of The Movement And Behaviour Of The Sand Crab (Portunus Pelagicus) Using Ultrasonic Tags
Funder
Fisheries Research and Development Corporation
Summary
Objectives: 1. Develop ultrasonic tags suitable for tracking & monitoring behaviour of sand crabs. 2. Develop simple methods of tracking tagged free-ranging crabs in Moreton Bay. 3. Obtain positional & Behavioural information over 24-hour periods to map movement of individual crabs