Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100011
Funder
Australian Research Council
Funding Amount
$900,000.00
Summary
Integrated Multimodal System for Multiplexed Imaging of Signal Transduction. This project will introduce a unique microscopy platform and associated technologies into the Australian research environment that will enable researchers to redefine our understanding of molecular signal transduction. The instrumentation will enable the multidimensional imaging of live cells with unprecendented speed and sensitivity. The featured imaging modalities will enable the integration of distinct biological, ....Integrated Multimodal System for Multiplexed Imaging of Signal Transduction. This project will introduce a unique microscopy platform and associated technologies into the Australian research environment that will enable researchers to redefine our understanding of molecular signal transduction. The instrumentation will enable the multidimensional imaging of live cells with unprecendented speed and sensitivity. The featured imaging modalities will enable the integration of distinct biological, biochemical and chemical probes with a focus on minimizing phototoxicity. Expected outcomes include new fundamental knowledge on molecular signal transduction and cell heterogeneity; development of novel probes and methodologies and the development of new and existing interdisciplinary research collaborations. Read moreRead less
Gamete-specific knockout of Fizzy-Related to examine its meiotic role in oocytes and sperm. Fizzy-Related is a gene that appears to be essential in making an ovulated egg, and it may also have an important role to play in making sperm. A mouse knockout will be generated to examine exactly how it functions; because it affects the egg number remaining in the ovary and egg quality Fizzy-Related may be eventually an important therapeutic target.
The Role Of Melanoma Tumour Antigen P97 (Melanotransferrin) In Melanoma Tumourigenesis.
Funder
National Health and Medical Research Council
Funding Amount
$563,242.00
Summary
The Role of Melanoma Tumour Antigen p97 (Melanotransferrin) in Melanoma Tumourigenesis Melanotransferrin (MTf) is a homologue of the iron transport protein, transferrin, and was one of the first well characterised melanoma tumour antigens. Our published studies have shown that MTf plays an important role in melanoma tumourigenesis in vivo. In this proposal, we will assess if it is associated with melanoma progression in patient samples and examine its role in melanoma growth and metastasis.
Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This k ....Control of developmental switches by importin 5. Aims: This project will study a key molecular switch called IPO5, a protein that is required for cells and organs to form and function normally, and it will reveal how it works.
Significance: These experiments will provide the first complete description of how this molecular switch controls the behaviour of a cell across its lifespan. IPO5 is highly conserved, so these studies will be relevant to a wide range of animals.
Expected Outcomes: This knowledge will reveal how IPO5 controls formation of sperm by revealing what other proteins it binds to and how this affects cell signaling and responses to the environment.
Benefits: This will provide information about potential interventions to control fertility or to repair abnormal cells.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100001
Funder
Australian Research Council
Funding Amount
$875,000.00
Summary
A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected out ....A 3-photon imaging system for deep live imaging. This project aims to establish Australia’s first 3-photon microscope system with adaptive optics for deep intravital imaging. This advanced imaging system will enable researchers to investigate the biology of cells and tissue structures in a wide range of organs and engineered tissues, to a degree not possible with existing technology. This project will capitalise on advanced laser, microscope and adaptive optics technologies with the expected outcomes to include the generation of new knowledge of major biological systems, including the immune system and the nervous system. This will provide significant benefits to fundamental interdisciplinary research into immunology, infectious disease, neuroscience, mechanobiology and engineering.Read moreRead less
Role of Musashi in the regulation of cell cycle proteins. We have identified a protein family that directs cell fate and maintains male fertility. This project will provide new avenues for generation of contraceptives in male animals and to regulate stem cells for production of specialised cell types in biotechnological applications.
How ribosomal protein loss affects cell fate. This project aims to challenge the dogma that the ribosome behaves only as a ‘‘house-keeper’’. Ribosomal protein (RP) mutations should, and often do, result in reduced cell growth and stunted animal development. Depletion of RPs in Drosophila blood cells impair stem cells and cause massive tissue overgrowth. This suggests RPs are involved in cell fate determination, which this project will research using genetic models. As ribosomal function is funda ....How ribosomal protein loss affects cell fate. This project aims to challenge the dogma that the ribosome behaves only as a ‘‘house-keeper’’. Ribosomal protein (RP) mutations should, and often do, result in reduced cell growth and stunted animal development. Depletion of RPs in Drosophila blood cells impair stem cells and cause massive tissue overgrowth. This suggests RPs are involved in cell fate determination, which this project will research using genetic models. As ribosomal function is fundamental to the development of all living organisms, this work could have wide implications for understanding all biology – from microbes, insects and plants to humans.Read moreRead less
Australian Seasonal Workers Programme and well-being impacts in Timor-Leste. This research aims to investigate the impacts of Australia’s Seasonal Workers Programme and South Korea’s Employment Permit System on the well-being of migrant workers and their families in Timor-Leste (East Timor). The contribution of this research to scholarship would be the creation of a sound method to measure the impact of temporary labour migration on well-being across various aspects of life that can be used by r ....Australian Seasonal Workers Programme and well-being impacts in Timor-Leste. This research aims to investigate the impacts of Australia’s Seasonal Workers Programme and South Korea’s Employment Permit System on the well-being of migrant workers and their families in Timor-Leste (East Timor). The contribution of this research to scholarship would be the creation of a sound method to measure the impact of temporary labour migration on well-being across various aspects of life that can be used by researchers in Timor-Leste and elsewhere to evaluate the development impacts of such migration schemes. The data will inform evidence-based policies to improve temporary labour migration schemes, meet urgent development priorities in Timor-Leste, and maximise the benefits of Australian aid funded labour migration schemes.Read moreRead less
Special Research Initiatives - Grant ID: SR0354802
Funder
Australian Research Council
Funding Amount
$40,000.00
Summary
Migration and its socio-economic and cultural consequences in Australia. This network will develop an interdisciplinary multi-layered approach to understanding migration processes and the related social, health and economic effects. With the input of scholars in diverse fields, the network will play a significant role in the development of a national migration database, in training early career researchers and in developing social policy. It will also stimulate new areas of research, integrate t ....Migration and its socio-economic and cultural consequences in Australia. This network will develop an interdisciplinary multi-layered approach to understanding migration processes and the related social, health and economic effects. With the input of scholars in diverse fields, the network will play a significant role in the development of a national migration database, in training early career researchers and in developing social policy. It will also stimulate new areas of research, integrate the dynamics of migrant populations with migrants' own experiences and perceptions, add to knowledge in the priority area 'safeguarding Australia', and enhance our understanding of the cultural, social and economic impact on Australia of a significant migrant presence.Read moreRead less
Inconsistent migration data in the Asia Pacific. This project aims to develop statistical models of population movements in the Asia-Pacific regionto harmonise, correct for errors and estimate annual flows by origin, destination, age and sex. International migration is increasing and thriving in the Asia-Pacific region but data on the annual movements and pathways are largely unknown because the data are unavailable for cross-national comparison. This is surprising considering the region makes u ....Inconsistent migration data in the Asia Pacific. This project aims to develop statistical models of population movements in the Asia-Pacific regionto harmonise, correct for errors and estimate annual flows by origin, destination, age and sex. International migration is increasing and thriving in the Asia-Pacific region but data on the annual movements and pathways are largely unknown because the data are unavailable for cross-national comparison. This is surprising considering the region makes up over three-fifths of the world’s population. The results are expected to form a basis for understanding the dynamics and complexity of migration in countries near Australia.Read moreRead less