Investigating Post-transcriptional Gene Regulation In Cancer
Funder
National Health and Medical Research Council
Funding Amount
$645,205.00
Summary
In this program, I will enhance our understanding of cancer gene regulation and provide novel avenues for the treatment of aggressive tumours. Using own data and that from collaborators, I will determine patterns of gene regulation in blood cancers and identify markers that predict disease outcome. I aim to understand how gene regulation can transform healthy cells into tumour cells and whether personalised treatment can kill tumour cells more effectively and prevent relapse and metastasis.
Microbiome Regulation of the Host Mitochondrial Genome. This project aims to describe newly discovered processes by which bacteria that reside in the gut of an animal influences host mitochondria, the powerhouses of the cell. Using advanced genetic and molecular methodologies, this project aims to generate new knowledge on improving mitochondrial function as well as advance our understanding of the emerging field of microbiome research. Expected outcomes include a novel and universal technology ....Microbiome Regulation of the Host Mitochondrial Genome. This project aims to describe newly discovered processes by which bacteria that reside in the gut of an animal influences host mitochondria, the powerhouses of the cell. Using advanced genetic and molecular methodologies, this project aims to generate new knowledge on improving mitochondrial function as well as advance our understanding of the emerging field of microbiome research. Expected outcomes include a novel and universal technology platform in which to engineer small molecules and probiotics to improve mitochondrial health and enhance fitness in a range of animals. This should provide significant benefits, through both scientifically relevant outcomes and economic benefits through technological advancements.Read moreRead less
Post-GWAS Functional Characterisation Of Breast Cancer Susceptibility Loci
Funder
National Health and Medical Research Council
Funding Amount
$764,632.00
Summary
Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. Several of these regions do not contain any known genes, suggesting that regulatory DNA sequences are responsible for the associated risk. The aim of this proposal is to identify and characterise these DNA sequences. Understanding how sequences variations in these regions contribute to breast cancer will provide novel avenues for therapy.
Engineering the defence-vigour balance for increased crop yield. This project aims to investigate a novel hypothesis to increase seed yield and vigour. Translating from a model system it will test whether the deliberate inactivation of a gene in tomato and banana, by RNA interference or genome editing, enhances performance. A dysfunctional gene in the viral defence pathway of the model plant species N. benthamiana boosted its seed yield and vigour. This project will investigate the enhancement, ....Engineering the defence-vigour balance for increased crop yield. This project aims to investigate a novel hypothesis to increase seed yield and vigour. Translating from a model system it will test whether the deliberate inactivation of a gene in tomato and banana, by RNA interference or genome editing, enhances performance. A dysfunctional gene in the viral defence pathway of the model plant species N. benthamiana boosted its seed yield and vigour. This project will investigate the enhancement, determine the consequences to the plant's defences, measure the balance between defence and vigour, and examine the risk of disease to such yield-enhanced crops. This is a radical departure from conventional approaches to crop improvement but if successful would provide an additional solution to the problem of future food security.Read moreRead less
Macrophage Polarisation And Control Of Pulmonary Inflammation.
Funder
National Health and Medical Research Council
Funding Amount
$895,494.00
Summary
As key immune cells, macrophages are polarised to phenotypes that turn inflammation on or off. In cystic fibrosis, defective macrophage polarisation enhances inflammation and prevents lung repair. We are defining the molecules and cellular pathways that control this process and identifying targets for existing drugs that can be used to reprogram macrophages and restore lung repair to improve patient outcomes.
Immunomodulatory Vaccines In The Treatment Of Peanut Allergy
Funder
National Health and Medical Research Council
Funding Amount
$678,899.00
Summary
Peanut allergy is the most common cause of food-induced anaphylactic reactions in Australia and is a major burden to our healthcare system. Current clinical practice advice dietary avoidance to prevent fatal anaphylactic responses. We propose the use of an immunomodulatory vaccine to re-write the immune response to peanut antigens, from an allergic to a tolerant phenotype. This study will provide novel insights into rational approaches for manipulating immune memory to food allergens.
Identifying Novel Long-noncoding RNAs Involved In The Development Of Breast Cancer
Funder
National Health and Medical Research Council
Funding Amount
$785,204.00
Summary
Recent studies have identified regions within the human genome in which DNA sequence variations are associated with an increased risk of breast cancer. The aim of this proposal is to identify and characterise these non-coding genes that are modulate breast cancer risk. Understanding how sequences variations that alter these novel genes contribute to breast cancer will provide novel avenues for therapy.
We have identified genetic abnormalities in 5% of breast cancers that fall in a novel DNA element called BIME1. This proposal aims to determine whether these genetic abnormalities contribute to breast tumourigenesis and which genes and pathways are affected by these mutations. The outcomes of this proposal may lead to the development of novel therapies for breast cancer or could influence the choice of existing therapies for patients that harbour these genetic abnormalities.
Investigating The Molecular Signature Of ASD Through Integrative Genomics
Funder
National Health and Medical Research Council
Funding Amount
$621,128.00
Summary
Autism is the most severe end of a spectrum of neurodevelopmental conditions, autism spectrum disorders (ASD). We have identified a signature of genes dysregulated in the brain of autistic individuals. The proposed project will investigate how the molecular signature of autism is regulated in the brain, and whether genetic variants in regulatory DNA contribute to the genetic architecture of ASD.