Hierarchically porous polymer monoliths for separation science. Understanding the molecular composition of biomarkers involved in cell-cell communication and the fate of nanoparticles in the environment is critical to improve our understanding of diseases and environmental processes. This project will develop a new approach for the design of separation media that will greatly improve the efficiency of techniques used to analyse these complex samples. The separation media will consist of a polyme ....Hierarchically porous polymer monoliths for separation science. Understanding the molecular composition of biomarkers involved in cell-cell communication and the fate of nanoparticles in the environment is critical to improve our understanding of diseases and environmental processes. This project will develop a new approach for the design of separation media that will greatly improve the efficiency of techniques used to analyse these complex samples. The separation media will consist of a polymer containing large flow-through pores as well as well-defined mesopores. This dual porous skeleton will allow for the size-based separation of biomarkers and nanoparticles. The new separation media will enable the development of new technologies with applications in areas such medicine and environmental science.Read moreRead less
Avoiding cryogenic solids formation in liquefied natural gas production. This project will determine how and under what conditions cryogenic hydrocarbon solids form during liquefied natural gas (LNG) production, which often cause expensive unplanned plant shutdowns. New sensors will be developed to understand and monitor the conditions which cause these blockages and will be deployed into LNG plants to avoid the critical conditions.
Mitigation of silica nanoparticle scaling in water treatment. This project aims to develop strategies to mitigate silica scaling at coal seam gas (CSG) water treatment facilities. CSG is adsorbed to the surface of coal along fractures and cleats and released when pressure is reduced by removal of groundwater, which has chemistry specific to the region from which it is extracted. Desalination of produced water is severely impacted by mineral scaling on reverse osmosis membranes. This project will ....Mitigation of silica nanoparticle scaling in water treatment. This project aims to develop strategies to mitigate silica scaling at coal seam gas (CSG) water treatment facilities. CSG is adsorbed to the surface of coal along fractures and cleats and released when pressure is reduced by removal of groundwater, which has chemistry specific to the region from which it is extracted. Desalination of produced water is severely impacted by mineral scaling on reverse osmosis membranes. This project will consider silica and silica-rich nanoparticles in concert with cations and organics, with the aim of better managing cations so to facilitate nanoparticle lubrication. Project outcomes may include more productive use of assets, improved pre-treatment infrastructure to support reverse osmosis operation, and the environmental benefits of reduced chemical waste and increased water recovery.Read moreRead less
Desalting reclaimed wastewater to safeguard Virginia's horticultural industries. Virginia is a major horticultural region of South Australia undergoing rapid expansion. Groundwater resources are depleted and reclaimed sewage effluent from Adelaide is required for irrigation. Unfortunately, the effluent is frequently too saline. Large-scale desalting is being considered. A pilot-scale plant will be built to evaluate suitable desalting processes (e.g. reverse osmosis) for reducing the effluent ....Desalting reclaimed wastewater to safeguard Virginia's horticultural industries. Virginia is a major horticultural region of South Australia undergoing rapid expansion. Groundwater resources are depleted and reclaimed sewage effluent from Adelaide is required for irrigation. Unfortunately, the effluent is frequently too saline. Large-scale desalting is being considered. A pilot-scale plant will be built to evaluate suitable desalting processes (e.g. reverse osmosis) for reducing the effluent's salt content. Original research will: (i) synthesize the best combination of technologies to produce effluent streams of varying salinity for matching different crop requirements; and (ii) optimise delivery and storage of effluent streams using new storage(s) and the region's multiple aquifer and surface storages.Read moreRead less
Desalination Options for Metropolitan Adelaide's Water Supply & Implications for Water Resource Allocation to Regional Communities. This project will present a proposal for water supply augmentation by desalination to alleviate rising salinity concerns and supply uncertainty of River Murray water supplies to metropolitan Adelaide in South Australia. It will investigate the feasibility of desalination options available and their consequences for regional agriculture and industry that rely on rive ....Desalination Options for Metropolitan Adelaide's Water Supply & Implications for Water Resource Allocation to Regional Communities. This project will present a proposal for water supply augmentation by desalination to alleviate rising salinity concerns and supply uncertainty of River Murray water supplies to metropolitan Adelaide in South Australia. It will investigate the feasibility of desalination options available and their consequences for regional agriculture and industry that rely on river water from metropolitan water supply pipelines for their economic survival. The project outcomes will have significant implications for government water policies and private and public sector water-infrastructure investment. It will be the first detailed study of large-scale municipal desalting costs under Australian conditions.Read moreRead less
Extraction of flavour enhancers, antimicrobials and nutraceuticals from olive mill effluent. The project aims to recover valuable materials from olive mill waste. Natural flavours will be recovered from the wastewater and from the dry pomice after oil extraction. The research and development will see these flavour compounds added back to olive oil to enhance the flavours of bland oils and to increase the shelf life of olive oil. The same compounds also have uses as enhancing the flavours of food ....Extraction of flavour enhancers, antimicrobials and nutraceuticals from olive mill effluent. The project aims to recover valuable materials from olive mill waste. Natural flavours will be recovered from the wastewater and from the dry pomice after oil extraction. The research and development will see these flavour compounds added back to olive oil to enhance the flavours of bland oils and to increase the shelf life of olive oil. The same compounds also have uses as enhancing the flavours of foods in general and provide a source of naturally occurring antioxidants. The compounds will be tested as natural antibiotics as a means of controlling fungal infections in vineyards and in vegetable production. Read moreRead less
Electrochemical biosensors for detection of cardiac disease markers in blood. Cardiovascular diseases leading to heart failure have a prevalence of over 16 per cent in Australia. The social, economic and health burden is higher than for any other disease group. Hence, it is critically important to develop fit-for-purpose sensors of known cardiac biomarkers, which alert patients and clinicians of the risk of imminent heart failure.
Mechanisms controlling enteroendocrine hormone secretion in human duodenum. This project aims to gain a deeper understanding of nutrient sensing pathways present in enteroendocrine cells within the human intestine. These cells control digestive function, blood glucose levels and food intake and are thus critical to digestion. This project will endeavour to be the first to assess the biology of human enteroendocrine cells and will use innovative approaches to deeply assess function from the level ....Mechanisms controlling enteroendocrine hormone secretion in human duodenum. This project aims to gain a deeper understanding of nutrient sensing pathways present in enteroendocrine cells within the human intestine. These cells control digestive function, blood glucose levels and food intake and are thus critical to digestion. This project will endeavour to be the first to assess the biology of human enteroendocrine cells and will use innovative approaches to deeply assess function from the level of the individual to isolated enteroendocrine cells.Read moreRead less
Determining the regulation of vitamin D metabolism. The proposed project will lead to a better understanding of factors that influence the biological function of vitamin D. This will impact in several areas of human health and will provide new avenues for the development of preventative approaches and treatment of cancer. This project is based on the use of 'Frontier Technologies' that will be applied to elucidate basic biological questions.
The mechanisms and roles of receptor clustering in cell activation and wound healing by growth factors. Growth factors regulate cell proliferation, migration and differentation by interaction with receptors. Such receptors are usually localized at the cell surface, and require intracellular transduction systems to transmit the signal to the cell interior. We have recently shown the hormone-induced clustering of heterologous hormone receptors in cells, and that this occurs with the co-clustering ....The mechanisms and roles of receptor clustering in cell activation and wound healing by growth factors. Growth factors regulate cell proliferation, migration and differentation by interaction with receptors. Such receptors are usually localized at the cell surface, and require intracellular transduction systems to transmit the signal to the cell interior. We have recently shown the hormone-induced clustering of heterologous hormone receptors in cells, and that this occurs with the co-clustering of downstream signalling molecules at sites of engagement with the extracellular matrix. In addition, we have found that cells presented with an extracellular matrix respond better to subsequent growth factor stimulation. The project aims to determine the cellular mechanisms underlying receptor clustering and the basis of the receptor-extracellular matrix interaction. This will enhance our understanding of growth factor function in a number of conditions, including wound healing. We will extend our in vitro results to the animal model to define parameters for enhanced wound repair.Read moreRead less