ARC Centre for Functional Nanomaterials. The Centre will consist of leading researchers from four Australian universities, four CSIRO divisions, and two US research centres. The vision is to position Australia as a world leader in nanomaterials science and technology. The Centre will involve nanoscale science for building functional nanostructures of materials at the molecular level. It aims to develop new methods and techniques for self-assembling and characterizing nanomaterials with tailorabl ....ARC Centre for Functional Nanomaterials. The Centre will consist of leading researchers from four Australian universities, four CSIRO divisions, and two US research centres. The vision is to position Australia as a world leader in nanomaterials science and technology. The Centre will involve nanoscale science for building functional nanostructures of materials at the molecular level. It aims to develop new methods and techniques for self-assembling and characterizing nanomaterials with tailorable properties. The outcomes will include leading-edge science, the development of human capital, and intellectual property in new materials and products for applications in clean energy, environmental, and health care industries.Read moreRead less
Multifunctional trilayer separator for durable multivalent energy storage. This project aims to develop an important new family of economical, high energy, multivalent batteries based on an abundant element, sulphur. The project plans to design a new battery separator to enable long-term stability in sulphur-based rechargeable batteries. This type of separator is of critical importance in many membrane-involved energy storage technologies. The project plans to use leading-edge durable energy tec ....Multifunctional trilayer separator for durable multivalent energy storage. This project aims to develop an important new family of economical, high energy, multivalent batteries based on an abundant element, sulphur. The project plans to design a new battery separator to enable long-term stability in sulphur-based rechargeable batteries. This type of separator is of critical importance in many membrane-involved energy storage technologies. The project plans to use leading-edge durable energy technologies to strengthen the development of residential energy systems and the involvement of renewable energy sources in modern grid.Read moreRead less
Investigating The Cellular Response To Iron-Depletion: The Trilogy Of ASK1, Thioredoxin And Ribonucleotide Reductase
Funder
National Health and Medical Research Council
Funding Amount
$552,572.00
Summary
Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for t ....Iron is crucial for many essential biological processes. Recently, we demonstrated that iron-depletion can affects important signalling pathways (e.g., JNK and p38) that play important roles in growth arrest and apoptosis. This study is designed to investigate the cellular and molecular effects of iron depletion which currently remains unclear. The research is crucial for understanding: (1) the effects of iron deficiency and (2) for understanding the effects of iron chelators that are used for treating various diseases.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453295
Funder
Australian Research Council
Funding Amount
$369,697.00
Summary
NMR cryosystem for structural and functional biology. State-of-the-art hardware is requested for the 600-MHz NMR spectrometers situated at University of Sydney and UNSW. A cryosystem installed at USyd. will provide a massive boost in productivity and will allow projects previously inaccessible due to excessive turn-around times, or sensitivity or solubility problems to become tractable. This system will provide new opportunities to researchers from USyd., UNSW and ANU, but will restrict the ver ....NMR cryosystem for structural and functional biology. State-of-the-art hardware is requested for the 600-MHz NMR spectrometers situated at University of Sydney and UNSW. A cryosystem installed at USyd. will provide a massive boost in productivity and will allow projects previously inaccessible due to excessive turn-around times, or sensitivity or solubility problems to become tractable. This system will provide new opportunities to researchers from USyd., UNSW and ANU, but will restrict the versatility of the USyd. instrument. The installation of a TBI probe at UNSW will counter this, and provide a REAL network of NMR instruments across NSW and the ACT.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989084
Funder
Australian Research Council
Funding Amount
$275,000.00
Summary
Confocal Laser Scanning Microscopy for Live Cell Imaging. The University of Newcastle has invested heavily in its biological and life sciences to create a research nexus focusing on national research priorities in biotechnology and environmental protection. The Live Cell Imaging platform will be utilized by scientists researching such strategically important areas including developmental biology, intracellular signalling cascades, cell cycle dynamics, plant development and microbiology. Moreover ....Confocal Laser Scanning Microscopy for Live Cell Imaging. The University of Newcastle has invested heavily in its biological and life sciences to create a research nexus focusing on national research priorities in biotechnology and environmental protection. The Live Cell Imaging platform will be utilized by scientists researching such strategically important areas including developmental biology, intracellular signalling cascades, cell cycle dynamics, plant development and microbiology. Moreover, this component of the University's research portfolio plays a major role in the postgraduate training of young Australian scientists who will, in turn, fuel future developments in both the life sciences and biotechnology industries.Read moreRead less
Cellular signals controlling oocyte activation. This research will significantly advance our understanding of the basic biological processes that underpin the fertility rate of all mammals and are key to the immediate and future health and well-being of Australian landscape and society. Understanding the processes that maintain healthy quiescent oocytes over many years before activation and subsequent growth will enable development of methods of increasing productivity in domestic animals and en ....Cellular signals controlling oocyte activation. This research will significantly advance our understanding of the basic biological processes that underpin the fertility rate of all mammals and are key to the immediate and future health and well-being of Australian landscape and society. Understanding the processes that maintain healthy quiescent oocytes over many years before activation and subsequent growth will enable development of methods of increasing productivity in domestic animals and enhancing fertility in endangered species. Knowledge of these cellular mechanisms will underpin biotechnology platforms necessary for novel methods of feral animal population control thus contributing at multiple levels to an economically sustainable Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0214135
Funder
Australian Research Council
Funding Amount
$492,000.00
Summary
High performance protein crystallography. This proposal will provide state of the art high performance facilities for protein crystallography, bringing together the major structural biology groups in NSW and the ACT. A renewed focus on protein crystal structures will stimulate new interpretation and utilization of the vast amount of data that has come from genomics, especially the sequencing of the human genome. The proposed facility will generate new research collaborations between the partn ....High performance protein crystallography. This proposal will provide state of the art high performance facilities for protein crystallography, bringing together the major structural biology groups in NSW and the ACT. A renewed focus on protein crystal structures will stimulate new interpretation and utilization of the vast amount of data that has come from genomics, especially the sequencing of the human genome. The proposed facility will generate new research collaborations between the partner institutions which will result in advances in basic life sciences, biotechnology and biopharmaceuticals. The facility will complement regional initiatives in functional genomics, bioinformatics, proteomics and high-field NMR spectroscopy.Read moreRead less
A unified model of amino acid homeostasis. This project aims to develop a unified model of amino acid homeostasis in mammalian cells and apply it to brain cells. The model will be underpinned by a mathematical algorithm that allows predicting amino acid levels in the cytosol based on fundamental parameters such as transport and metabolism. This project should provide the significant benefit of enabling the prediction of essential functions such as cell growth and survival.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100096
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
A unique soft matter high-performance scanning probe microscopy (HP-SPM) facility. Soft matter research touches every aspect of our lives as it covers materials from the range of plastics found in cars, television sets and other mass-manufactured products, to new medical materials for tissue engineering and sensors. The proposed facility will enable Australia's leading scientists in this area to understand better how soft matter, including both biological and new advanced soft materials, behave ....A unique soft matter high-performance scanning probe microscopy (HP-SPM) facility. Soft matter research touches every aspect of our lives as it covers materials from the range of plastics found in cars, television sets and other mass-manufactured products, to new medical materials for tissue engineering and sensors. The proposed facility will enable Australia's leading scientists in this area to understand better how soft matter, including both biological and new advanced soft materials, behaves on the nano-scale level. This will put Australian researchers and engineers in a leading position for developing new treatments against cancer and other diseases, as well as harnessing the power of biology for application in areas such as waste treatment and energy production.Read moreRead less
Discovery of new genes for plant cellulose biosynthesis and improved fibre production. Cellulose, the world's most abundant biopolymer, is important to the cotton and forest industries and for human and animal nutrition. Before biotechnology can manipulate cellulose, we must identify the enzymes of the synthesis pathway and understand how their properties determine the properties of the cellulose they produce. Not all enzymes are known and any relationships to cellulose properties remain unexplo ....Discovery of new genes for plant cellulose biosynthesis and improved fibre production. Cellulose, the world's most abundant biopolymer, is important to the cotton and forest industries and for human and animal nutrition. Before biotechnology can manipulate cellulose, we must identify the enzymes of the synthesis pathway and understand how their properties determine the properties of the cellulose they produce. Not all enzymes are known and any relationships to cellulose properties remain unexplored. This study extends our successful mutational analysis of cellulose synthesis in Arabidopsis and initiates the molecular analysis of organisms making cellulose with distinctive properties. It will significantly advance knowledge of cellulose biosynthesis and identify novel genes for fibre improvement.Read moreRead less