Effect of Saline Water on Flotation Processes. The Australian mineral and coal industry is valued at $40 billion in export income per year. This significant component of the Australian economy will benefit from this research into the increased use of highly saline water to improve coal and mineral flotation recovery. The project will keep Australia at the leading edge of flotation research, research training and development for the coal and mineral industry. With direct relevance to the National ....Effect of Saline Water on Flotation Processes. The Australian mineral and coal industry is valued at $40 billion in export income per year. This significant component of the Australian economy will benefit from this research into the increased use of highly saline water to improve coal and mineral flotation recovery. The project will keep Australia at the leading edge of flotation research, research training and development for the coal and mineral industry. With direct relevance to the National Research Priorities: Water - a Critical Resource, this project will make contributions to the development of a more environmentally sustainable coal and mineral processing industry.Read moreRead less
Interfacial engineering of multilayered metal organic framework membranes . Metal-organic frameworks are a popular class of microporous materials with tunable structural properties and functionalities. This project aims to investigate the designed synthesis of thin, hierarchically structured films of this material on membranes, which displays extraordinary ion selectivity and ion rectification properties. A better understanding of the interfacial properties will be gained through advanced charac ....Interfacial engineering of multilayered metal organic framework membranes . Metal-organic frameworks are a popular class of microporous materials with tunable structural properties and functionalities. This project aims to investigate the designed synthesis of thin, hierarchically structured films of this material on membranes, which displays extraordinary ion selectivity and ion rectification properties. A better understanding of the interfacial properties will be gained through advanced characterisation, and with proper design and tuning of the film, will ultimately lead to the development of high performing ion-selective membranes that will be applied for energy storage and separation applications. This project is expected to benefit Australia’s renewable energy and resource sectors.Read moreRead less
Meshes of Oxide Nanofibres for Next-Generation Ceramic Membranes. Our next-generation ceramic membranes will increase the speed and efficiency of present industrial separations as well as expanding into a variety of new separations, thereby transforming many Australian industries. Exports of this new technology also will generate significant national benefits. Application of these new membranes to removing pollutants and pathogens from water and/or air will bring significant community benefits g ....Meshes of Oxide Nanofibres for Next-Generation Ceramic Membranes. Our next-generation ceramic membranes will increase the speed and efficiency of present industrial separations as well as expanding into a variety of new separations, thereby transforming many Australian industries. Exports of this new technology also will generate significant national benefits. Application of these new membranes to removing pollutants and pathogens from water and/or air will bring significant community benefits globally, addressing such crucial issues as low-cost provision of clean drinking water. Additionally, understanding the cutting-edge science associated with the mechanisms of nanofibre growth and the assembly of nanofibre meshes is highly valuable, making an important contribution to Australia's knowledge-economy.Read moreRead less
Putting metal organic frameworks to work at interfaces. This project aims to develop new strategies to better synthesize ultrathin Metal-organic framework (MOF) membranes by nanostructured and chemically functionalized substrates. MOF materials have enormous potential due to the extraordinary structural and chemical diversity of these crystalline microporous materials and their potential applications in gas storage, separation, catalysis and sensing. However, a major challenge is fabricating thi ....Putting metal organic frameworks to work at interfaces. This project aims to develop new strategies to better synthesize ultrathin Metal-organic framework (MOF) membranes by nanostructured and chemically functionalized substrates. MOF materials have enormous potential due to the extraordinary structural and chemical diversity of these crystalline microporous materials and their potential applications in gas storage, separation, catalysis and sensing. However, a major challenge is fabricating thin robust MOF films or patterns on porous, flexible, and nonporous substrates, quickly and easily in order to construct useful devices. The project will grow ultrathin layers of molecular sieving and electroactive MOFs to produce technology platforms for large scale device manufacturing.Read moreRead less
Understanding the potency and role of individual stem cells in the skin using Rainbow technology. To renew itself, the skin and its components rely on the activity of stem cells. This project will define more precisely the role of each individual stem cell by labelling them with a unique colour and following its fate. This project has the potential to change our current view on how the skin maintains and repairs itself.
Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cel ....Migration-Dependent Signalling in Macrophages . The project aims to investigate a mechanism of communication used by immune cells to guide each other towards sites of damage. The project will characterise newly revealed cell signalling membrane trails left behind by migrating cells, utilising biochemistry, innovative imaging and microscopy and a transparent zebrafish model to view cell migration through living tissues. Expected outcomes include new fundamental knowledge in the area of immune cell migration with relevance to the basic biology of inflammation, repair and regeneration and new innovations for cell imaging. Significant benefits are expected to arise from this new knowledge and from advanced skills training and improved national capabilities in bio-imaging and analysis.Read moreRead less
Chemical principles underpinning a spermostatic-microbiostatic agent capable of preventing pregnancy and the spread of sexually transmitted disease. This project explores the development of a method for simultaneously controlling fertility while preventing the spread of sexually transmitted diseases. A novel aspect of the approach, that will dramatically influence product development, is that the active principles will only be generated on contact with seminal plasma.
Enhancing neurogenesis in the adult primate brain. New neurons are robustly generated in the subependymal zone (SEZ) during human development. Thus, the SEZ may represent an endogenous modifiable source of neurons to enhance plasticity and therapeutic potential in the brain. However, despite our preliminary data, SEZ neurogenesis beyond the first months of life is controversial. This project aims to understand changes in the capacity for human SEZ proliferation from birth through to ageing and w ....Enhancing neurogenesis in the adult primate brain. New neurons are robustly generated in the subependymal zone (SEZ) during human development. Thus, the SEZ may represent an endogenous modifiable source of neurons to enhance plasticity and therapeutic potential in the brain. However, despite our preliminary data, SEZ neurogenesis beyond the first months of life is controversial. This project aims to understand changes in the capacity for human SEZ proliferation from birth through to ageing and whether neurogenesis may be induced by inflammation in the adult. Using transcriptomics we will also determine how the neurogenic environment changes with age/inflammation. This project is an important step in proving that the brain's potential to generate new neurons extends beyond infancy.Read moreRead less
Membrane Systems for CO2 Capture and Conversion Using Multi-Enzyme Cascades. Carbon capture and storage (CCS) is one of the defining technological challenges in today's industry and society. Primary sources of carbon dioxide (CO2) are due to energy generation using fossil fuels as well as key manufacturing activities such cement production and steel making. This project aims to focus on novel approaches to enzyme mediated membrane contactor systems to create robust, high efficiency CO2 capture f ....Membrane Systems for CO2 Capture and Conversion Using Multi-Enzyme Cascades. Carbon capture and storage (CCS) is one of the defining technological challenges in today's industry and society. Primary sources of carbon dioxide (CO2) are due to energy generation using fossil fuels as well as key manufacturing activities such cement production and steel making. This project aims to focus on novel approaches to enzyme mediated membrane contactor systems to create robust, high efficiency CO2 capture from post-combustion and other gas emissions and conversion into useful chemical feedstock. Enzyme immobilisation and stabilisation are expected to be enhanced using functionalised nanoparticles and nanostructured membranes.Read moreRead less
The biological and pathological functions of TDP-43. The social and economic burden of neurodegenerative such as MND is enormous. A key histopathological hallmark of this and many other related diseases are deposits of the protein TDP-43. Our research aims at understanding its largely unknown functions, for example by generating transgenic animal models. These will form the base for the development for a TDP-43-directed drug treatment. The national benefit of this research is manifold: by deciph ....The biological and pathological functions of TDP-43. The social and economic burden of neurodegenerative such as MND is enormous. A key histopathological hallmark of this and many other related diseases are deposits of the protein TDP-43. Our research aims at understanding its largely unknown functions, for example by generating transgenic animal models. These will form the base for the development for a TDP-43-directed drug treatment. The national benefit of this research is manifold: by deciphering basic biological mechanisms, patenting new data, developing treatment strategies for un-curable and fatal disorders, and expanding links to Australian biotech and international pharmaceutical companies.Read moreRead less