Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989491
Funder
Australian Research Council
Funding Amount
$172,025.00
Summary
Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemi ....Multi-Purpose Mass Spectrometry Facility. The Australian Centre for Research on Separation Science (ACROSS) has been established using focused research themes to provide both fundamental and applied research outcomes in separation science. The requested Time of Flight Mass Spectrometer (TOFMS) will be utilised extensively by a large team of researchers working across the broad areas of analytical chemistry, pharmaceutical science, materials science, biochemistry, microfluidics, industrial chemistry and hydrometallurgy, aquaculture, forensic analysis, Antarctic studies, and environmental monitoring. This will directly support our work falling under National Research Priorities 1 An Environmentally Sustainable Australia, 2 Promoting and Maintaining Good Health, 3 Frontier Technologies for Building and Transforming Australian Industries, and 4 Safeguarding Australia.Read moreRead less
On-fibre separation science with ambient ionisation mass spectrometry. This project aims to combine fibre-based electrofluidics and ambient ionisation mass spectrometry. Fibre-based electrophoresis is a separation technology which is cheaper, simpler and faster than pre-MS analyses. This project will use the fibre simultaneously as the ionisation platform for ambient mass spectrometry, combining the processes of separation and ionisation in a portable and flexible platform. The developed technol ....On-fibre separation science with ambient ionisation mass spectrometry. This project aims to combine fibre-based electrofluidics and ambient ionisation mass spectrometry. Fibre-based electrophoresis is a separation technology which is cheaper, simpler and faster than pre-MS analyses. This project will use the fibre simultaneously as the ionisation platform for ambient mass spectrometry, combining the processes of separation and ionisation in a portable and flexible platform. The developed technology is expected to provide new capability in bioanalysis, proteomics and rapid clinical diagnostics. Future benefits may include new commercial fibre based technologies which could be applied within industrial and clinical laboratories within the next ten years.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100140
Funder
Australian Research Council
Funding Amount
$275,000.00
Summary
Quarantined ion chromatography mass spectrometry (IC-MS) facility. This proposal seeks to establish a quarantined facility for 'ion chromatography-mass spectrometry', to provide high resolution ion chromatographic and mass spectrometric analytical capability to the environmental, analytical/bioanalyical, and industrial science research communities. The state-of-the-art facility will represent the only quarantined high-resolution IC-MS facility within Australia, and therefore not only support the ....Quarantined ion chromatography mass spectrometry (IC-MS) facility. This proposal seeks to establish a quarantined facility for 'ion chromatography-mass spectrometry', to provide high resolution ion chromatographic and mass spectrometric analytical capability to the environmental, analytical/bioanalyical, and industrial science research communities. The state-of-the-art facility will represent the only quarantined high-resolution IC-MS facility within Australia, and therefore not only support the above communities within Australia, but the potential to facilitate research collaboration internationally, including supporting Australia's leading Antarctic Science programs. Read moreRead less
Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge mic ....Visualising neuron-glia interactions in the injured central nervous system. The adult brain and spinal cord recovery poorly from injury. Attempts to overcome this problem include methods to promote the intrinsic regenerative capacity of injured neurons, and modulating the inhibitory extracellular environment to become permissive to regeneration. The goal of this project is to investigate an endogenous regenerative mechanism in the injured brain. This project will use the latest, cutting-edge microscopy techniques to visualise whether the endogenous astrocyte protein metallothionein can promote regeneration in the injured nervous system of living zebrafish. The successful outcomes of this project will provide significant insight into understanding how the brain responds to injury.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE100100107
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Purchase of a multi-purpose Schottky field emission gun scanning electron microscope. Scanning electron microscopy is a basic analytical tool for imaging surfaces of natural and synthetic materials and identification of nanometre-scale features and their compositions. At the University of Tasmania, it supports four of our six designated priority research themes: Antarctic and Marine Studies, Environment, Frontier Technologies, and Sustainable Primary Production. Our research depending on this te ....Purchase of a multi-purpose Schottky field emission gun scanning electron microscope. Scanning electron microscopy is a basic analytical tool for imaging surfaces of natural and synthetic materials and identification of nanometre-scale features and their compositions. At the University of Tasmania, it supports four of our six designated priority research themes: Antarctic and Marine Studies, Environment, Frontier Technologies, and Sustainable Primary Production. Our research depending on this technique includes many fundamental and applied topics from a wide range of disciplines, such as developing portable detection devices for explosives, finding more efficient and sustainable ways to explore for ore, investigating the effects of climate change on marine ecosystems and improving salinity and drought tolerance of crops.Read moreRead less
Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-th ....Investigating the molecular function of alpha-Haemoglobin stabilising protein. The research described in this proposal will provide new insights into haemoglobin regulation and redox chemistry in erythrocytes. Deregulation of these processes gives rise to a number of debilitating diseases, including varieties of anaemia and thalassaemia-in Australia it is estimated that 3% of the population could be carriers of b-thalassaemia mutations. Given the contribution of free aHb to the pathology of b-thalassaemia, understanding the specific aHb-binding factor, AHSP is a goal of national significance. In the long term, manipulation of AHSP function through gene therapy may have a direct role in the treatment of thalassaemia.Read moreRead less
Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to th ....Redefining the metallothionein's role in the injured brain: extracellular metallothioneins play an important role in astrocyte-neuron responses to injury. This project is being performed by an Australian team of researchers who are leaders in this field of research, and has significant national benefits in supporting this team reveal fundamental information on the cellular interactions that occur between astrocytes and neurons within the injured brain. In national terms, it will contribute to the concerted effort by Australian scientists to understand how and why neurons die following brain injury or neurodegenerative disease. Furthermore, this research contributes directly to the Designated National Research Priorities by identifying some of the earliest biochemical and cellular processes associated with aging or disease of the brain.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100075
Funder
Australian Research Council
Funding Amount
$315,000.00
Summary
Acoustic liquid handling robotics for bioactive compound discovery. This project aims to use a Labcyte Echo 550 acoustic dispenser with Combination Software to deliver sophisticated assay-ready screening. The Echo is the only liquid handling dispenser for 1536-well microplates and will allow Australian researchers to develop assay miniaturisation. The robotics will provide our nation’s researchers with a distinct competitive edge by enhancing assay sophistication, accuracy and reproducibility wh ....Acoustic liquid handling robotics for bioactive compound discovery. This project aims to use a Labcyte Echo 550 acoustic dispenser with Combination Software to deliver sophisticated assay-ready screening. The Echo is the only liquid handling dispenser for 1536-well microplates and will allow Australian researchers to develop assay miniaturisation. The robotics will provide our nation’s researchers with a distinct competitive edge by enhancing assay sophistication, accuracy and reproducibility while reducing cost. The expected benefits will advance the elucidation of molecular mechanisms involved in complex biological phenomena. The benefits of this are substantial, including reduction in test compound and reagents, which in turn reduces laboratory costs, conserves cells and increases data quality.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE200100043
Funder
Australian Research Council
Funding Amount
$389,000.00
Summary
Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies. This project aims to undertake fast probe-free biochemical/chemical imaging of heterogeneity within cells and materials surfaces with new infrared and Raman imaging. It will generate new fundamental knowledge on: cell heterogeneity and dynamic processes; technologies for optimising cell printing; understanding toxicity of microplastics; and protocols for measuring materials of technological relevance. Expected outcomes inc ....Rapid Molecular (Bio)material Imaging by Infrared and Raman Microscopies. This project aims to undertake fast probe-free biochemical/chemical imaging of heterogeneity within cells and materials surfaces with new infrared and Raman imaging. It will generate new fundamental knowledge on: cell heterogeneity and dynamic processes; technologies for optimising cell printing; understanding toxicity of microplastics; and protocols for measuring materials of technological relevance. Expected outcomes include: interdisciplinary collaborations in new protocols for in-vitro drug development; cell printing technologies; environmental impacts of microplastics; and materials design. Expected benefits include innovative approaches to early stage drug design; improved environmental controls and advances in innovative materials.Read moreRead less