Food structure design. Food structure design. This project aims to use fundamental studies in multi-scale rheology and biotribology, surface sciences, soft matter physics and protein chemistry to develop new measurement capabilities and knowledge for rational food structure design. This research is intended to enable researchers and industry to quantify how oral processing (including saliva) transforms food during consumption, and to provide new instrumental measurements and know-how that assist ....Food structure design. Food structure design. This project aims to use fundamental studies in multi-scale rheology and biotribology, surface sciences, soft matter physics and protein chemistry to develop new measurement capabilities and knowledge for rational food structure design. This research is intended to enable researchers and industry to quantify how oral processing (including saliva) transforms food during consumption, and to provide new instrumental measurements and know-how that assists in defining sensory percepts in dairy foods and beverages such as creaminess in full, reduced or non-fat systems and grittiness in high protein systems.Read moreRead less
Enabling the design of superior healthy snack foods and beverages through innovative assessment of oral processing and mucosal film interactions. Reducing sugar and fat in foods generally leads to products that are perceived as less flavoursome and appealing. A significant contributor to this is the interaction of foods and beverages with oral mucosal substrates, which play a key role in perceptual processes that drive unacceptable mouthfeel sensations. This project seeks to develop and use oral ....Enabling the design of superior healthy snack foods and beverages through innovative assessment of oral processing and mucosal film interactions. Reducing sugar and fat in foods generally leads to products that are perceived as less flavoursome and appealing. A significant contributor to this is the interaction of foods and beverages with oral mucosal substrates, which play a key role in perceptual processes that drive unacceptable mouthfeel sensations. This project seeks to develop and use oral mimetic substrates to permit objective and quantified rheological and tribological responses, imitating the underlying physics occurring during food oral processing that drive dynamic sensory responses. The project aims to enable a mechanism-based approach to minimise the amounts of fat, salt and sugar required for sensory properties that meet consumer expectations.Read moreRead less
Understanding self-organising tissues. This project will discover how an organ can form from a mixture of component cells by 'self-organisation'. Understanding of how this can occur, could potentially be applied to the bioengineering of organs from component cells.
Programming anisotropy into responsive soft materials. The project aims to generate viscoelastic soft materials with programmable anisotropy using aqueous suspensions of colloidal rods that have tunable surface coatings. The project expects to generate new knowledge in the rheology and structural characteristics of this unique class of materials. A key innovation is the use of charge-directed polymer self-assembly to control colloidal interactions, suspension rheology and phase behaviour. The in ....Programming anisotropy into responsive soft materials. The project aims to generate viscoelastic soft materials with programmable anisotropy using aqueous suspensions of colloidal rods that have tunable surface coatings. The project expects to generate new knowledge in the rheology and structural characteristics of this unique class of materials. A key innovation is the use of charge-directed polymer self-assembly to control colloidal interactions, suspension rheology and phase behaviour. The intended outcome is spatial control over the orientation of nanostructures, potentially mimicking the structural hierarchy found in nature. This should provide significant benefits to the creation of viscoelastic materials with complex rheology as well as structural, mechanical and optical heterogeneity.Read moreRead less
Engineering biomimetic lubrication with mucin. Engineering coatings for water to be an effective lubricant is a significant challenge. The project seeks to emulate how nature builds highly lubricating water-rich polymer films on biological surfaces. This is intended to be achieved by directing the self-assembly of mucin macromolecules onto polymer brushes attached to a substrate, and then cross-linking the constituents to obtain a hydrated gel-like lubricating coating. This research is expected ....Engineering biomimetic lubrication with mucin. Engineering coatings for water to be an effective lubricant is a significant challenge. The project seeks to emulate how nature builds highly lubricating water-rich polymer films on biological surfaces. This is intended to be achieved by directing the self-assembly of mucin macromolecules onto polymer brushes attached to a substrate, and then cross-linking the constituents to obtain a hydrated gel-like lubricating coating. This research is expected to provide new insights on the mechanisms by which mucin-rich fluids lubricate and protect biosurfaces, which is important to human health, nutrition and well-being. It may also lead to new discoveries for engineering surface coatings for biomaterials and nanomaterials.Read moreRead less
New nanotechnology controlling wettability in unconventional gas reservoirs. This project aims to develop new nanoparticle technologies to change rock wettability and significantly increase gas production from shale and coal seam gas fields. The project plans to use a unique combination of new theoretical models for suspension transport in fractures and innovative mathematical modelling supported by laboratory studies and validated against field results, to test and develop the new strategies fo ....New nanotechnology controlling wettability in unconventional gas reservoirs. This project aims to develop new nanoparticle technologies to change rock wettability and significantly increase gas production from shale and coal seam gas fields. The project plans to use a unique combination of new theoretical models for suspension transport in fractures and innovative mathematical modelling supported by laboratory studies and validated against field results, to test and develop the new strategies for Australian gas fields. The project is expected to improve understanding of complex physical phenomena associated with natural gas production and to deliver economic benefit to the Australian gas industry.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130101191
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Formation of the osteocyte network in bone matrix. The formation of new bone, which occurs throughout life for bone renewal and acutely after fractures, entraps a network of cells that can detect micro-damage and direct repair mechanisms. Mathematical and computational methods will be used to understand how this network can lead to a self-detecting and self-repairing biomaterial.
Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors w ....Protein biosensors for detecting smoke exposure of grapes. Bush fires and controlled burns that take place in the vicinity of vineyards can lead to grape contamination with tasteless phenolic glucosides. Their hydrolysis during wine making leads to “smoke taint” – an unpleasant medicinal taste that can render wine undrinkable. We will apply a combination of organic synthesis, protein engineering and directed evolution to develop protein-based biosensors of phenolic glucosides. These biosensors will be used to devise a simple portable colorimetric test that can be performed in the vineyard or the winery. The ability to rapidly determine the level of grape contamination with phenolic glucosides would give Australian wine growers and wine makers a powerful tool to mitigate the effects of bushfires.Read moreRead less
Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to r ....Controlling the adhesome to regulate cell fate on biomaterials. Mesenchymal stem cell-based tissue engineering practices are hampered worldwide by the lack of appreciation and understanding of the matrix-mediated cues that must be provided during adhesion and spreading to drive cells to definitive tissue end points. This project will address these knowledge deficiencies by combining high throughput array technologies, a set of tailorable self-assembling biomaterials and real-time biosensors to rapidly, at high resolution, elucidate how mechanotransductive cues determine the fate choice of mesenchymal stem cells, and furthermore, how to manipulate them with smart biomaterial design to achieve desired outcomes for tissue engineering. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100200
Funder
Australian Research Council
Funding Amount
$270,427.00
Summary
AutoStem: a high performance, automated stem cell bioengineering facility. This project aims to establish an automated stem cell bioengineering ("AutoStem") facility that will enable critical insights into the molecular mechanisms that underly the loss in stem cell function and tissue homeostasis as we age. The AutoStem facility expects to lead to the discovery of the key drivers of stem cell ageing and the development of novel technological solutions to maintain tissue function with age. The o ....AutoStem: a high performance, automated stem cell bioengineering facility. This project aims to establish an automated stem cell bioengineering ("AutoStem") facility that will enable critical insights into the molecular mechanisms that underly the loss in stem cell function and tissue homeostasis as we age. The AutoStem facility expects to lead to the discovery of the key drivers of stem cell ageing and the development of novel technological solutions to maintain tissue function with age. The outcomes produced from the AutoStem facility will have significant economic and social benefits in enabling healthy ageing and increased productivity for an ageing Australia.Read moreRead less