Heparan sulfate complexes with VEGF for control of angiogenesis in tissue engineered constructs. The national/community benefits that will arise from this work include, the generation of knowledge related to the growth of blood vessels in the presence of a synthetic polymer that has been made to look like the natural polymers present in the body. This will lead to an understanding of the underlying mechanisms involved that may have down stream effects relevant to the replacement of many types o ....Heparan sulfate complexes with VEGF for control of angiogenesis in tissue engineered constructs. The national/community benefits that will arise from this work include, the generation of knowledge related to the growth of blood vessels in the presence of a synthetic polymer that has been made to look like the natural polymers present in the body. This will lead to an understanding of the underlying mechanisms involved that may have down stream effects relevant to the replacement of many types of tissues being generated for clinical applications, including possible applications in the treatment of heart disease, the largest killer of people in the Western world. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775684
Funder
Australian Research Council
Funding Amount
$230,000.00
Summary
The polymer pharmaceutical/drug characterization and processing facility. The Australian population is ageing, and this is leading to ever increasing burdens upon our health system. In addition new understanding of disease states has lead to a demand for improved materials for drug delivery and for tissue regeneration. This proposal will lead to novel biomaterials designed to meet these demands. Polymers are seen as essential elements for construction of such biomedical devices due to the myriad ....The polymer pharmaceutical/drug characterization and processing facility. The Australian population is ageing, and this is leading to ever increasing burdens upon our health system. In addition new understanding of disease states has lead to a demand for improved materials for drug delivery and for tissue regeneration. This proposal will lead to novel biomaterials designed to meet these demands. Polymers are seen as essential elements for construction of such biomedical devices due to the myriad forms in which they can be made, and the large number of different materials to choose from. This proposal will lead to the formation of the PolyPharma network which will produce polymeric biomaterials to benefit our health industries.Read moreRead less
Single molecule actuators. The study of actuation processes in single molecules will lead to the development of improved advanced materials for Australian industry and, ultimately, to the more futuristic and exciting nanotechnologies. The research will improve our understanding of how polymer artificial muscles function, so that these materials can be further developed to meet the demand from industry. Applications include biomedical devices, robotic applicators and various machine parts. In ....Single molecule actuators. The study of actuation processes in single molecules will lead to the development of improved advanced materials for Australian industry and, ultimately, to the more futuristic and exciting nanotechnologies. The research will improve our understanding of how polymer artificial muscles function, so that these materials can be further developed to meet the demand from industry. Applications include biomedical devices, robotic applicators and various machine parts. In addition, the research will also contribute to one of the greatest promises of nanotechnology: the development of molecular machines. We will demonstrate the mechanical forces and movements possible from single molecules so that the design of useful nano-machines can begin.Read moreRead less
Advanced Materials for Stents. The polymer based materials targeted for production in this project will bring unique capabilities to the field of stent design. A multi-component degradable stent system is expected to bring significant improvements in vascular therapeutic treatments for a wide range of illnesses and applications. This will have significant advantages over current treatment and will have a positive impact on the quality of life of patients. The project brings together world leader ....Advanced Materials for Stents. The polymer based materials targeted for production in this project will bring unique capabilities to the field of stent design. A multi-component degradable stent system is expected to bring significant improvements in vascular therapeutic treatments for a wide range of illnesses and applications. This will have significant advantages over current treatment and will have a positive impact on the quality of life of patients. The project brings together world leaders in their respective fields to address a highly multidisciplinary are of research and will provide excellent training for the PhDs and post doctoral research associates, enabling them to work in and contribute to the development of new biomedical industries in Australia.Read moreRead less
Functionalised nanostructured polythiophenes: novel platforms for bionics. The nanostructured organic polymer materials targeted for production in this project will bring unique capabilities to the field of muscle regeneration. A multi-modal stimulation platform is expected to bring significant improvements in muscle cell growth. This will have profound effects on the quality of life for those suffering from neuromuscular disorders or other traumas that require muscle regeneration. This project ....Functionalised nanostructured polythiophenes: novel platforms for bionics. The nanostructured organic polymer materials targeted for production in this project will bring unique capabilities to the field of muscle regeneration. A multi-modal stimulation platform is expected to bring significant improvements in muscle cell growth. This will have profound effects on the quality of life for those suffering from neuromuscular disorders or other traumas that require muscle regeneration. This project will demonstrate the capabilities of these nanostructures in-vitro.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347937
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Imaging Raman Spectrometer. An Imaging Raman spectrometer generates image maps 10x faster than older instruments and is required to meet escalating demand. This results from innovative use of Raman to characterise organics, polymers, thin films and biomaterials, which underpins rapidly evolving research in nanotechnology and biotechnology. Many innovations have come from QUT's Centre for Instrumental and Developmental Chemistry, which will host the spectrometer and is a key resource for all Qu ....Imaging Raman Spectrometer. An Imaging Raman spectrometer generates image maps 10x faster than older instruments and is required to meet escalating demand. This results from innovative use of Raman to characterise organics, polymers, thin films and biomaterials, which underpins rapidly evolving research in nanotechnology and biotechnology. Many innovations have come from QUT's Centre for Instrumental and Developmental Chemistry, which will host the spectrometer and is a key resource for all Queensland universities. The availability of its high quality spectroscopic facility has enabled leading edge developments by local companies and the Imaging Raman spectrometer will significantly accelerate and enhance current and future project outcomes.Read moreRead less
Nanostructured materials by controlled photopolymerization. Photo-polymerization is an important and flexible means of converting a crosslinkable monomer into a solid and has application ranging from lens production to photo-lithography. This project aims at developing the technology of producing multi-phase structures of controllable morphology by selective and independent dual photo-polymerization of blends of crosslinkable monomers at controlled rates. These morphologies may have applicatio ....Nanostructured materials by controlled photopolymerization. Photo-polymerization is an important and flexible means of converting a crosslinkable monomer into a solid and has application ranging from lens production to photo-lithography. This project aims at developing the technology of producing multi-phase structures of controllable morphology by selective and independent dual photo-polymerization of blends of crosslinkable monomers at controlled rates. These morphologies may have applications in toughening polymers with minimum loss in strength and optical transparency, abrasion resistant coatings, tissue engineering (where the phases have differing biodegradability), in microfluidics, and microelectro-mechanical systems (where sub-micron channels/domains are required) or in membrane separation.Read moreRead less