Understanding The Impact Of Social, Economic And Geographic Disadvantage On The Health Of Australians In Mid - Later Lif
Funder
National Health and Medical Research Council
Funding Amount
$1,943,571.00
Summary
This research will examine the ways in which social, economic and environmental factors contribute to the health of Australians in mid to later life. It will help identify ways in which policy and preventive programs can contribute to improving health in mid to later life particularly among disadvantaged Australians. We will explore in detail social, economic and environmental factors in 100,000 people aged 45 and over; this will be the largest study of its kind ever undertaken in Australia. We ....This research will examine the ways in which social, economic and environmental factors contribute to the health of Australians in mid to later life. It will help identify ways in which policy and preventive programs can contribute to improving health in mid to later life particularly among disadvantaged Australians. We will explore in detail social, economic and environmental factors in 100,000 people aged 45 and over; this will be the largest study of its kind ever undertaken in Australia. We will examine the relationship between these social, economic factors, and lifestyle factors such as smoking, physical activity, environmental and obesity. This will enable us to identify where programs and policies should be directed to most rapidly improve the health of disadvantaged Australians.Read moreRead less
Automatic detection and modelling of acoustic markers of speech timing. This project aims to create new automatic sensing, analysis and assessment of cognitive, affective, mental and physical state from voice for mobile and computing devices. This project expects to generate new understanding of the effects of these states on detailed timing indicators of speech motor control, and new signal processing and machine learning methods that best exploit it. Expected outcomes from this project include ....Automatic detection and modelling of acoustic markers of speech timing. This project aims to create new automatic sensing, analysis and assessment of cognitive, affective, mental and physical state from voice for mobile and computing devices. This project expects to generate new understanding of the effects of these states on detailed timing indicators of speech motor control, and new signal processing and machine learning methods that best exploit it. Expected outcomes from this project include a new and accurate deep neural network framework for learning, analysing and detecting human states from speech automatically using articulatory timing markers. This should provide significant benefits, such as individually-tailored, frequent and low-cost automatic detection, monitoring and analytics for adverse states.Read moreRead less
A Unique Network Of Phagocytic Cells At The Interface Between The Liver And Peritoneal Cavity
Funder
National Health and Medical Research Council
Funding Amount
$787,521.00
Summary
This project aims to characterise the nature and ontogeny of a novel population of cells with phagocytic capacity that forms a network underlying the capsule of mouse and human liver reminiscent of that formed by Langherans cells in the epidermis of the skin. In this project we will characterise this newly described liver capsular macrophage subset, define their ontogeny and assess their specific functions.
Deciphering The Transcriptional Program That Instructs Lymphatic Endothelial Cell Fate.
Funder
National Health and Medical Research Council
Funding Amount
$541,950.00
Summary
Lymphatic vessels are essential to maintain fluid balance in most tissues of the human body. Further the lymphatic vasculature plays a central role during cancer and contributes to tumour metastasis. Despite this integral function in health and disease little is known about the molecular programs that coordinate gene expression to build a functional vasculature. This research project will address this gap in our knowledge and will open up new therapeutic avenues for lymphatic vascular disorders
Disparities In Care And Outcome For People With Lung Cancer
Funder
National Health and Medical Research Council
Funding Amount
$74,047.00
Summary
This thesis will investigate disparities in lung cancer care and outcomes, provide an overview of lung cancer disparities in NSW and seek to identify and assess an intervention to reduce lung cancer disparities. This will involve a systematic review of cancer disparity measures, empirical research to investigate patterns and predictors of disparity. Mixed methods will be used to investigate observed disparities and identify interventions to improve cancer care and outcomes in vulnerable groups.
Cultural responsiveness: measuring and evaluating social work practice. This project aims to develop tools for use by social workers that measure and evaluate culturally responsive practices with Aboriginal and Torres Strait Islander peoples. The tools have potential application across numerous sectors in social work practices with clients and families. The project will benefit social workers who can measure, evaluate and improve their culturally responsive practice, and in turn, the health and ....Cultural responsiveness: measuring and evaluating social work practice. This project aims to develop tools for use by social workers that measure and evaluate culturally responsive practices with Aboriginal and Torres Strait Islander peoples. The tools have potential application across numerous sectors in social work practices with clients and families. The project will benefit social workers who can measure, evaluate and improve their culturally responsive practice, and in turn, the health and well-being outcomes for Aboriginal and Torres Strait Islander peoples.Read moreRead less
Minimally invasive monitoring of sleep for disease management. Sleep, diet and exercise are the three pillars of wellbeing with poor sleep associated with medical issues such as obesity and congestive heart failure. This project will advance sleep analysis by researching new ways of monitoring that are highly accurate and convenient, enabling physicians to improve the monitoring of significant health issues.
The Role Of Melanoma Tumour Antigen P97 (Melanotransferrin) In Melanoma Tumourigenesis.
Funder
National Health and Medical Research Council
Funding Amount
$563,242.00
Summary
The Role of Melanoma Tumour Antigen p97 (Melanotransferrin) in Melanoma Tumourigenesis Melanotransferrin (MTf) is a homologue of the iron transport protein, transferrin, and was one of the first well characterised melanoma tumour antigens. Our published studies have shown that MTf plays an important role in melanoma tumourigenesis in vivo. In this proposal, we will assess if it is associated with melanoma progression in patient samples and examine its role in melanoma growth and metastasis.
The Immunoregulatory Role of the Endogenous Cannabinoid Anandamide. Anandamides are naturally occurring fatty acids that act at the cannabinoid receptor expressed in the brain and periphery. A new proposal by our research group challenges traditional models of the disease process by suggesting that the anandamide system is an important imunoregulatory system that can be targeted by invading pathogens. We propose that disruption to the anandamide system, by bacteria or viruses acting at the rece ....The Immunoregulatory Role of the Endogenous Cannabinoid Anandamide. Anandamides are naturally occurring fatty acids that act at the cannabinoid receptor expressed in the brain and periphery. A new proposal by our research group challenges traditional models of the disease process by suggesting that the anandamide system is an important imunoregulatory system that can be targeted by invading pathogens. We propose that disruption to the anandamide system, by bacteria or viruses acting at the receptor to block immunological responses, contributes to chronic illness states. At this point we have good evidence that anandamides are immunoregulators, however, we have very little knowledge of their precise physiological role. The aim of this research is to begin to characterise the immunoregulatory role of the anandamide system. This project will provide a comprehensive understanding of this endogenous control system, the immunological properties of which have not previously been described. The outcome of this research may lead to the identification of new avenues for the development of pharmaceutical interventions that can target this system.Read moreRead less