The Impact Of Sleep Disturbance On Cardiometabolic Function
Funder
National Health and Medical Research Council
Funding Amount
$295,223.00
Summary
Excess cardiovascular death is common in rotating shiftwork and obstructive sleep apnoea (OSA) populations. Substantial evidence links sleep disturbance in both ‘states’ to these adverse outcomes. This research will quantify the cardiovascular risk that sleep disturbance poses in both populations, determine whether people with untreated OSA who engage in shiftwork have amplified risk and determine whether a novel diet of high protein during shiftwork reduces risk. The findings may provide strate ....Excess cardiovascular death is common in rotating shiftwork and obstructive sleep apnoea (OSA) populations. Substantial evidence links sleep disturbance in both ‘states’ to these adverse outcomes. This research will quantify the cardiovascular risk that sleep disturbance poses in both populations, determine whether people with untreated OSA who engage in shiftwork have amplified risk and determine whether a novel diet of high protein during shiftwork reduces risk. The findings may provide strategies that could improve health in shiftworkers.Read moreRead less
Dysfunction In Anterior Cingulate Brain Networks: Implementations For Psychiatric And Substance Use Disorders
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
Psychiatric and substance use disorders are associated with significant morbidity and mortality. Recent evidence points to discrete brain networks as being critically involved in the neurobiology of these disorders. Using novel brain imaging techniques, this research will increase our knowledge of how these brain networks are involved in these disorders. This will represent an important step towards elucidating their biological underpinnings and improving outcomes for affected patients.
Utilising Human Primary Immunodeficiencies To Study Lymphocyte Differentiation
Funder
National Health and Medical Research Council
Funding Amount
$429,346.00
Summary
Human immunodeficiencies are diseases arising from naturally occurring mutations. In this instance, the specific genes mutated in the immunodeficiencies we study have been identified. However, it is unclear how defects in these genes make an individual manifest as an immune deficient state, rendering them vulnerable to disease. By studying immune cells from these individuals we hope to uncover the normal function of these genes and subsequently provide for new therapies for these conditions.
Cellular Pathogenesis Of Key Proteins Involved In Neurodegenerative Disorders
Funder
National Health and Medical Research Council
Funding Amount
$312,730.00
Summary
Prion proteins are involved in neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD) and Bovine Spongiform Encephalopathy (BSE). The aim of this research proposal is to investigate factors which can change the prion protein from a normal, benign, form into an abnormal shape which can cause disease. The outcomes of this work will provide further insight into the role of prion proteins in these diseases and also for other neurodegenerative disorders such as Alzheimer's disease.