Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989861
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
Electron Microscopes for Nanometer-Scale Imaging/Microanalysis in the Materials, Biological, Physical, Engineering and Chemical Sciences. Electron microscopes have contributed to many of the most significant discoveries and technological advances of the last 6 decades. High resolution transmission and scanning electron microscopes have become essential research infrastructure in internationally competitive materials science, biology, bio-medical science, physics, chemistry and a broad range of e ....Electron Microscopes for Nanometer-Scale Imaging/Microanalysis in the Materials, Biological, Physical, Engineering and Chemical Sciences. Electron microscopes have contributed to many of the most significant discoveries and technological advances of the last 6 decades. High resolution transmission and scanning electron microscopes have become essential research infrastructure in internationally competitive materials science, biology, bio-medical science, physics, chemistry and a broad range of engineering disciplines. This capability is not currently available in the Newcastle, Hunter, Central and Lower North Coast and New England regions. This proposal is aimed at satisfying the considerable demand for high resolution microscopy in these areas leading to high quality research outcomes across 3 National Research Priorities and a strong contribution to research training.Read moreRead less
GENOMIC/PHENOMIC IDENTIFICATION AND CHARACTERISATION OF NOVEL HEMATOPOIETIC REGULATORS. Blood cells are fundamental to health. They play a vital role in maintaining the condition of tissues and organs, fight infections and are essential players in the body's response to injury. Understanding how blood cells are produced and how they function is critical to improving the treatment of disease. With the sequencing of the genome, we now have the tools we need to find the genes controlling these proc ....GENOMIC/PHENOMIC IDENTIFICATION AND CHARACTERISATION OF NOVEL HEMATOPOIETIC REGULATORS. Blood cells are fundamental to health. They play a vital role in maintaining the condition of tissues and organs, fight infections and are essential players in the body's response to injury. Understanding how blood cells are produced and how they function is critical to improving the treatment of disease. With the sequencing of the genome, we now have the tools we need to find the genes controlling these processes. This project will harness the power of modern genetic technologies to dissect the role of novel genes involved in blood cell formation and function, and will open up new therapeutic opportunities for treating the many diseases associated with dysregulation of this important cell system. Read moreRead less
Hybrid cooling for coal fired power stations. Water shortage is a nation wide problem facing Australian industries. The project will directly benefit the Victorian power industry through water saving. If the new proposed hybrid cooling system concept is proved to be practically feasible, it will put the Australian power industry in a strong competitive position in terms of its efficiencies and waste heat recovery technology. Lowering the temperature of water into the cooling tower by 2 degree, b ....Hybrid cooling for coal fired power stations. Water shortage is a nation wide problem facing Australian industries. The project will directly benefit the Victorian power industry through water saving. If the new proposed hybrid cooling system concept is proved to be practically feasible, it will put the Australian power industry in a strong competitive position in terms of its efficiencies and waste heat recovery technology. Lowering the temperature of water into the cooling tower by 2 degree, by using the hybrid cooling system, it would save over 17,500,000 tons of makeup water per year for the Victorian power industry alone. At the same time, the waste heat recovered by the heat pump can be fed back to the power generation cycle. Read moreRead less
Hydro-mechanical interactions in coal geo-sequestration of carbon dioxide. One of the most critical environmental issues facing society is that of global warming because of increasing concentrations of carbon dioxide released from burning of fossil fuels. Storage of CO2 in the ground, geo-sequestration, offers the promise of significant reductions in atmospheric CO2 release, particularly from coal fired power stations which produce 40% of Australia's CO2 emissions. The proposed project will lead ....Hydro-mechanical interactions in coal geo-sequestration of carbon dioxide. One of the most critical environmental issues facing society is that of global warming because of increasing concentrations of carbon dioxide released from burning of fossil fuels. Storage of CO2 in the ground, geo-sequestration, offers the promise of significant reductions in atmospheric CO2 release, particularly from coal fired power stations which produce 40% of Australia's CO2 emissions. The proposed project will lead to greater understanding and reduced risks during the injection and storage of CO2 in deep unmineable coal deposits. This will contribute to national efforts to reduce global warming, safeguard the Australian coal industry, and allow continued electricity generation from coal-fired plants. Read moreRead less
Monitoring and Modelling Hydrogeochemical Interactions with Groundwater : Implications for Mine Dewatering on Groundwater, River and Lake Chemistry. Alcoa operates a power station and brown coal mine at Anglesea in western Victoria. Following heavy rain in 2000 acidic water entered the Anglesea estuary causing precipitation of iron and aluminium flocs and fish kills. Estuary closure to tourism resulted. This project will identify the cause(s) of this phenomenon by modelling groundwater movement ....Monitoring and Modelling Hydrogeochemical Interactions with Groundwater : Implications for Mine Dewatering on Groundwater, River and Lake Chemistry. Alcoa operates a power station and brown coal mine at Anglesea in western Victoria. Following heavy rain in 2000 acidic water entered the Anglesea estuary causing precipitation of iron and aluminium flocs and fish kills. Estuary closure to tourism resulted. This project will identify the cause(s) of this phenomenon by modelling groundwater movement and studying geochemical processes. The resultant hydrogeochemical model will also be applied to simulating longer term water quality changes in the catchment arising from current mine dewatering operations and future rewatering following mine closure.
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The Axis Of Bcl-2, Plasmacytoid DCs And Lupus As A Basis For Therapy
Funder
National Health and Medical Research Council
Funding Amount
$712,172.00
Summary
Systemic lupus erythematosus (SLE) affects 1 in 1000 Australians, mostly women. Here the immune system goes awry and makes antibodies against the body’s own components including the body’s DNA. This leads to damage to many parts of the body including kidneys, joints, brain and heart. It is incurable. A particular immune cell controls the development of this disease and we have found this cell is selectively killed by an inexpensive drug, which we hope will be a better way of treating SLE.
Microtubule structure in nervous system repair. This Project aims to investigate the role of structural and functional cellular components known as microtubules in nervous system regeneration. This Project aims to use innovative approaches in confocal and electron microscopy, genetics, and cell biology, with the expectation of generating new knowledge into nervous system repair. Expected outcomes of this Project include a comprehensive description of how microtubules are rearranged following ner ....Microtubule structure in nervous system repair. This Project aims to investigate the role of structural and functional cellular components known as microtubules in nervous system regeneration. This Project aims to use innovative approaches in confocal and electron microscopy, genetics, and cell biology, with the expectation of generating new knowledge into nervous system repair. Expected outcomes of this Project include a comprehensive description of how microtubules are rearranged following nervous system injury and the importance of microtubule modifying proteins in promoting regeneration. This should provide significant benefits in our understanding of the cellular mechanisms behind nervous system repair, and offer new approaches for promoting regeneration after injury.Read moreRead less
Numerical and experimental studies of the gas-particle flow and dust collection in electrostatic precipitation systems. This project will generate an integrated computer model to describe the gas-solid flow and dust collection in an ElectroStatic Precipitator (ESP). The model can be used to aid the design and control of ESP systems which are widely used for dust collection, leading to more competitive energy and related industries.
Synthesis of functionalised metal oxide beads with hierarchical pores for radionuclide and metal sequestration. The central aim of this project is to fabricate nanostructured materials to address the worldwide issue of nuclear waste. These novel materials, with tailored porosity and surface functionality, will decrease both radioactive waste volume and the potential for environmental risk. The collaboration between the Caruso group at the University of Melbourne and the Luca group at ANSTO will ....Synthesis of functionalised metal oxide beads with hierarchical pores for radionuclide and metal sequestration. The central aim of this project is to fabricate nanostructured materials to address the worldwide issue of nuclear waste. These novel materials, with tailored porosity and surface functionality, will decrease both radioactive waste volume and the potential for environmental risk. The collaboration between the Caruso group at the University of Melbourne and the Luca group at ANSTO will educate more scientists and students in the areas of nuclear science and engineering, and the environmental impact of nuclear power generators. Such expertise is currently in high demand around the world, thereby enhancing Australia's position in the global nuclear field.Read moreRead less
An assessment of carbon dioxide storage capacity of water bearing sedimentary basins. Dealing with the problems caused by climate change and global warming is among the greatest challenges facing Australia today. One of the approaches being considered to minimise anthropogenic influence over climate is the geo-sequestration of carbon dioxide (CO2). The proposed project will lead to greater understanding of storage capacity of sedimentary basins and identification of optimum injection conditions ....An assessment of carbon dioxide storage capacity of water bearing sedimentary basins. Dealing with the problems caused by climate change and global warming is among the greatest challenges facing Australia today. One of the approaches being considered to minimise anthropogenic influence over climate is the geo-sequestration of carbon dioxide (CO2). The proposed project will lead to greater understanding of storage capacity of sedimentary basins and identification of optimum injection conditions for geo-sequestration in such aquifers, and any potential mechanisms that could lead to migration of CO2 from the source rock back to the atmosphere.This will contribute to national efforts to reduce global warming, safeguard the Australian economy, and allow continued electricity generation from coal-fired plants.Read moreRead less