A Central Role For ER-Golgi Trafficking In Motor Neuron Disease
Funder
National Health and Medical Research Council
Funding Amount
$434,652.00
Summary
Amyotrophic lateral sclerosis (ALS) patients currently face a bleak future. In the common global form of disease, the average length of survival after diagnosis is 31 months. Current therapies have at best a modest effect on the course of the disease with little or no benefit in terms of overall patient survival. This study will address the basic underlying biochemical mechanisms of disease in both sporadic and genetic forms of ALS. This studies will lead to opportunities to develop new therapie ....Amyotrophic lateral sclerosis (ALS) patients currently face a bleak future. In the common global form of disease, the average length of survival after diagnosis is 31 months. Current therapies have at best a modest effect on the course of the disease with little or no benefit in terms of overall patient survival. This study will address the basic underlying biochemical mechanisms of disease in both sporadic and genetic forms of ALS. This studies will lead to opportunities to develop new therapies in the future.Read moreRead less
Axonal Fusion To Promote Nerve Repair: Molecules And Mechanisms.
Funder
National Health and Medical Research Council
Funding Amount
$456,189.00
Summary
Nerve injuries are in most cases untreatable, leaving patients with high level of disabilities for the rest of their life. Understanding the molecular mechanism regulating nerve regeneration is critical to develop new drugs and design innovative therapies. We discovered molecules that mediates axonal repair by favouring the stitching together of the two separated fragments of an axon. We aim to study how they functions to possibly exploit a similar mechanism of repair for human injuries.
Understanding The Role Of TDP-43 In Motor Neuron Disease.
Funder
National Health and Medical Research Council
Funding Amount
$654,091.00
Summary
Motor neuron disease (MND) is a fatal neurodegenerative disease with no cure. The cause of MND is poorly understood but new research has shown that defects in TDP-43, an RNA binding protein involved in gene regulation, can lead to the disease. This project is aimed at discovering the molecular mechanisms of TDP-43 function, which will improve the understanding of the disease and aid in the development of new therapies.
MOLECULAR CELL BIOLOGICAL ANALYSIS OF CAVEOLIN SECRETION
Funder
National Health and Medical Research Council
Funding Amount
$536,657.00
Summary
Aggressive forms of prostate cancer are associated with the release of a protein, called caveolin, from the cancerous cells. Caveolin is normally embedded in the cell surface and drives the formation of microscopic pits termed caveolae. In this proposal we will investigate how caveolin is secreted with a long-term goal of preventing the secretion, or the action, of caveolin.
Behavioural responses to transport congestion: peak spreading and the more efficient usage of transport infrastructure. Transport networks in cities such as Sydney are at or near capacity. It is no longer socially, environmentally or financially sustainable to continue supplying additional transport infrastructure to meet increased demand. An alternative is to make better use of existing infrastructure by spreading demand more evenly across the day. This project will test behavioural responses t ....Behavioural responses to transport congestion: peak spreading and the more efficient usage of transport infrastructure. Transport networks in cities such as Sydney are at or near capacity. It is no longer socially, environmentally or financially sustainable to continue supplying additional transport infrastructure to meet increased demand. An alternative is to make better use of existing infrastructure by spreading demand more evenly across the day. This project will test behavioural responses to increased congestion and quantify the phenomenon of peak spreading. It will assess economic costs and benefits of using congestion as a signal to encourage more efficient network usage, and examine other tools (e.g. time-based transport pricing) to encourage more efficient use of transport infrastructure.Read moreRead less
Multidimensional evaluation of the overall benefits of voluntary travel behaviour change programs. Voluntary Travel Behaviour Programs (VTBC) offer considerable promise for the management of traffic congestion and reduction in greenhouse gas and air quality emissions from road transport. Research to date has identified two outstanding issues: (1) measurement and evaluation of actual behaviour change and (2) identification of the full benefits and impacts of VTBC. Empirical studies indicate that ....Multidimensional evaluation of the overall benefits of voluntary travel behaviour change programs. Voluntary Travel Behaviour Programs (VTBC) offer considerable promise for the management of traffic congestion and reduction in greenhouse gas and air quality emissions from road transport. Research to date has identified two outstanding issues: (1) measurement and evaluation of actual behaviour change and (2) identification of the full benefits and impacts of VTBC. Empirical studies indicate that many of the benefits fall outside the transport area, including a wide range of socio-economic benefits to individuals and the community. This project will develop a survey tool for assessing benefits and impacts of VTBC within a properly designed and tested evaluation framework.Read moreRead less
Promoting active travel and public transport for a post-pandemic world. In many major cities, COVID-19 stimulated the provision of open streets, pop up bike lanes and widened pedestrian access, prompting unprecedented increases cycling and walking. While this type of infrastructure has always been supported by urban planners and designers, the pandemic has served as a vital inflection point, enabling cities to pursue long-term sustainable transport initiatives, including investment in Active Tra ....Promoting active travel and public transport for a post-pandemic world. In many major cities, COVID-19 stimulated the provision of open streets, pop up bike lanes and widened pedestrian access, prompting unprecedented increases cycling and walking. While this type of infrastructure has always been supported by urban planners and designers, the pandemic has served as a vital inflection point, enabling cities to pursue long-term sustainable transport initiatives, including investment in Active Travel (AT). There is an opportunity to promote AT as part of an integrated transport strategy, and to develop tools for the robust evaluation of AT impacts to inform future investment strategies. This proposal will provide our partner organisation Transport for New South Wales (with the knowledge required to achieve this.
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Prediction and control of fluid-structure interactions. Fluid-flows create a pressure that can deform the surface of a structure or cause it to vibrate; an extreme example is the fluttering of a flag. Flow-induced vibration of the external panels of vehicles causes damage, noise and can adversely affect performance. This project will develop a wholly new approach for the analysis of these interactions. The versatility and completeness of the approach permits a step-change in the design of panels ....Prediction and control of fluid-structure interactions. Fluid-flows create a pressure that can deform the surface of a structure or cause it to vibrate; an extreme example is the fluttering of a flag. Flow-induced vibration of the external panels of vehicles causes damage, noise and can adversely affect performance. This project will develop a wholly new approach for the analysis of these interactions. The versatility and completeness of the approach permits a step-change in the design of panels, reducing material and manufacturing costs without compromise to safety and performance - an immense benefit for the myriad engineered products or structures that feature flow over a deformable surface. Read moreRead less
Taming turbulence: Hydrodynamic stability and flow-structure interaction using grid-free computation. Turbulence is characterized as seemingly disordered fluctuations that impede the progress of an object through a fluid by creating increased frictional or drag forces. Using a new type of fluid-flow simulation, this project will generate advanced understanding of turbulence in the flow over the surface of a vehicle, be it a ship, car, aircraft or within a pipe, with the technological objective o ....Taming turbulence: Hydrodynamic stability and flow-structure interaction using grid-free computation. Turbulence is characterized as seemingly disordered fluctuations that impede the progress of an object through a fluid by creating increased frictional or drag forces. Using a new type of fluid-flow simulation, this project will generate advanced understanding of turbulence in the flow over the surface of a vehicle, be it a ship, car, aircraft or within a pipe, with the technological objective of reducing drag by adhering a compliant skin to the surface. While the correct choice of compliance relies upon understanding very complex flow-structure dynamics, the resulting technology is simple, robust and has low capital and maintenance costs. Clearly, drag reduction reduces fuel costs and lower fuel consumption is environmentally beneficial. Read moreRead less