Understanding The Physiological Advantage Behind Delayed Cord Clamping.
Funder
National Health and Medical Research Council
Funding Amount
$647,539.00
Summary
Surviving the transition to newborn life at birth is critically dependent upon a major re-organization of the infant’s circulation which is triggered by umbilical cord occlusion and the onset of air-breathing. This application is focused on investigating procedures that assist in stabilising the circulation during the newborn period and protect it from large swings in cardiac output and blood flow that have the potential to cause vascular-related injury in newborn infants.
Implementing Neuroprotective Strategies For Fetal Growth Restriction
Funder
National Health and Medical Research Council
Funding Amount
$782,370.00
Summary
Fetal growth restriction (FGR) is a serious and common complication of pregnancy that is a principal cause of injury to the developing fetal brain. In turn, damage to the developing brain during pregnancy may cause cerebral palsy and other cognitive and behavioural deficits. This proposal builds on my work to date characterising the mechanisms that contribute to neuropathology in FGR infants, by implementing targeted strategies to protect or repair the FGR brain.
New And Improved Treatment Strategies For Neonatal Seizures
Funder
National Health and Medical Research Council
Funding Amount
$883,209.00
Summary
Around 10% of neonates in Australia are diagnosed with seizures each year. Seizures worsen neurodevelopmental outcome following hypoxic brain injury. Despite evidence of the limited effectiveness and potential neurotoxicity of current anti-seizure medication, treatment has not changed for many decades. The objective of this study is to optimise treatment of neonatal seizures with a compound that is effective and does not cause harm, or indeed provides neuroprotection for the compromised brain.
Evaluating Appropriate Use Of Blood Products In Mothers And Babies
Funder
National Health and Medical Research Council
Funding Amount
$392,137.00
Summary
There has been an increase in blood transfusions following childbirth. Blood transfusions are potentially life-saving treatments for mothers and babies facing life-threatening illnesses or complications involving haemorrhage, however there is potential to be over-transfusing mothers and babies who are exposed to unnecessary risk of adverse outcomes such as infection. We aim to evaluate and improve the safety and appropriate use of blood and blood products during pregnancy, childbirth and the new ....There has been an increase in blood transfusions following childbirth. Blood transfusions are potentially life-saving treatments for mothers and babies facing life-threatening illnesses or complications involving haemorrhage, however there is potential to be over-transfusing mothers and babies who are exposed to unnecessary risk of adverse outcomes such as infection. We aim to evaluate and improve the safety and appropriate use of blood and blood products during pregnancy, childbirth and the newborn period.Read moreRead less
Can Esomeprazole Improve Outcomes In Women At High Risk Of Pre-eclampsia? A Phase II Placebo-controlled Randomised, Multi-centre Clinical Trial.
Funder
National Health and Medical Research Council
Funding Amount
$1,597,125.00
Summary
Pre-eclampsia, recognised through the development of high blood pressure in pregnancy, causes death and/or injury to mothers and babies. An improved understanding of the development of pre-eclampsia has provided opportunities for early prediction and prevention of disease. We will use a powerful predictive model to identify pregnancies at high risk of pre-eclampsia then observe the effect of a novel treatment (esomeprazole) on maternal blood pressure and the development of this disease.
Exploring The Impact Of Blood Transfusion On Maternity Outcomes And Healthcare Utilisation: Informing The Use Of Blood And Blood Products In The Obstetric Setting
Funder
National Health and Medical Research Council
Funding Amount
$492,479.00
Summary
Around 1 in 10 women suffer excessive bleeding after childbirth, 15% of whom will have a blood transfusion. New guidelines for obstetric blood management will be released in 2015. This research will investigate obstetric transfusion practices before and after guideline implementation. Research aims include identifying variation in treatment of women at risk of and experiencing transfusion, addressing knowledge gaps in guidelines and investigating emerging issues in obstetric transfusion medicine