ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Genomic Analysis Of DNA Binding And Gene Regulation By The Chromatin Remodelling Factor UBF
Funder
National Health and Medical Research Council
Funding Amount
$624,254.00
Summary
Synthesis of ribosomes, the cellular protein synthetic machinery, is the major anabolic event of a growing cell and is frequently dysregulated during disease such as cancer. This grant will examine a protein termed UBF that we think plays an important role in orchestrating the cellular response to dysregulated ribosome biogenesis. By understanding how UBF functions we hope to uncover novel therapeutic approaches to treat diseases associated with ribosome stress .
Regulation Of Ribosomal RNA Gene Chromatin During Malignant Transformation.
Funder
National Health and Medical Research Council
Funding Amount
$882,486.00
Summary
The overarching goal of this proposal is to determine the molecular basis for tumour cell dependence on activated ribosomal RNA gene repeats (rDNA). Our working model posits that rDNA repeats become activated through changes in rDNA chromatin structure that include increased binding of the RNA Polymerase I transcription factor UBF.
Gassing Mechanism and Stability of Foamed Explosive Emulsions. Mining of minerals such as coal involves crushing the surrounding rock strata, or the mineral ore itself, with emulsion explosives. One of the most important properties determining suitability of an emulsion explosive to a particular mining operation is its velocity of detonation, which can be adjusted by varying the number and size of air bubbles distributed in the emulsion matrix. The present project aims to develop new ways of g ....Gassing Mechanism and Stability of Foamed Explosive Emulsions. Mining of minerals such as coal involves crushing the surrounding rock strata, or the mineral ore itself, with emulsion explosives. One of the most important properties determining suitability of an emulsion explosive to a particular mining operation is its velocity of detonation, which can be adjusted by varying the number and size of air bubbles distributed in the emulsion matrix. The present project aims to develop new ways of generating air bubbles, to gain fundamental understanding of the foaming mechanism in currently used gassing techniques, and to invent ways to stabilise large bubbles within the emulsion. The project will provide scientific underpinning for the development of a new range of emulsion explosives manufactured by Orica for Australian and international markets, maintaining the Orica's position as a leader in the field of emulsion explosives.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0883036
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials, and Medical Research. The expected benefits that will arise will include: green chemical processes with improved environmental and economic impacts; improved treatments and diagnoses of diseases; understanding of fundamental geological processes; identification of the earliest forms; studies of archaeological artefacts; evolution of life on Earth; the design of improved dental materials. Ultimatel ....Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials, and Medical Research. The expected benefits that will arise will include: green chemical processes with improved environmental and economic impacts; improved treatments and diagnoses of diseases; understanding of fundamental geological processes; identification of the earliest forms; studies of archaeological artefacts; evolution of life on Earth; the design of improved dental materials. Ultimately, this research will include economic and social benefits in; industrial processes; the mining industry; medicine; and dentistry. An understanding of the origin and early evolution of life on Earth also has many social implications.Read moreRead less
A new molecular platform for catalytic synthesis of heterocycles. This project aims to address the lack of efficient methods to prepare cyclic molecules of biological relevance by utilising novel molecular platforms developed in our laboratories. This project expects to generate new cyclic molecules using these innovative molecular platforms by employing catalysts to reduce raw material and energy cost. The expected outcomes of this project include enhanced chemical technology to prepare cyclic ....A new molecular platform for catalytic synthesis of heterocycles. This project aims to address the lack of efficient methods to prepare cyclic molecules of biological relevance by utilising novel molecular platforms developed in our laboratories. This project expects to generate new cyclic molecules using these innovative molecular platforms by employing catalysts to reduce raw material and energy cost. The expected outcomes of this project include enhanced chemical technology to prepare cyclic molecules of pharmaceutical importance and the training of highly skilled PhD students. This should provide significant benefits, such as increased capacity for the development of new pharmaceuticals and advanced materials.Read moreRead less
Role of Reactive Particles in Explosive Emulsions. Concentrated water-in oil explosive emulsions are widely used in the minerals industry because they are cheap, easily detonated and relatively safe to handle. Their explosive energy can be significantly increased when reactive particles are introduced into the emulsion matrix. To do this, the interaction between the solid, oil, and water phases needs to be optimised. This investigation will increase our basic understanding of the physical and ch ....Role of Reactive Particles in Explosive Emulsions. Concentrated water-in oil explosive emulsions are widely used in the minerals industry because they are cheap, easily detonated and relatively safe to handle. Their explosive energy can be significantly increased when reactive particles are introduced into the emulsion matrix. To do this, the interaction between the solid, oil, and water phases needs to be optimised. This investigation will increase our basic understanding of the physical and chemical interactions that occur between the particle and the oil-water interface, and develop a more efficient explosive that can be produced continuously on a commercial scale.Read moreRead less
Synthesis and Fundamental Understanding of Low-Dimensional Metal Oxide Nanoparticles for Gas Sensing Application. This project is primarily devoted to material science and nanotechnology, one of the cutting-edge areas in Australia's National Research Priority. Successful completion of this project will result in controlled synthesis, functional assembly and fundamental understanding of low-dimensional metal oxide nanostructures. The research findings will be useful for developing new and complex ....Synthesis and Fundamental Understanding of Low-Dimensional Metal Oxide Nanoparticles for Gas Sensing Application. This project is primarily devoted to material science and nanotechnology, one of the cutting-edge areas in Australia's National Research Priority. Successful completion of this project will result in controlled synthesis, functional assembly and fundamental understanding of low-dimensional metal oxide nanostructures. The research findings will be useful for developing new and complex nanostructures for functional applications in lithium ionic batteries, catalysts and gas sensors. The conduct of this project will significantly expand the knowledge creativity of Australia in advanced materials.
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Discovery And Development Of Better Pain Treatments
Funder
National Health and Medical Research Council
Funding Amount
$9,613,850.00
Summary
Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clini ....Many forms of pain remain poorly treated, leading to significant quality of life and economic losses. This Program grant will discover and characterise new peptides from cone snails and spiders that modulate specific channels in nerves that are critical to the transmission of pain signals to the brain. Using advanced chemical and structural approaches, promising leads will be optimised for potency and stability and evaluated in disease and pathway-specific models of pain to establish their clinical potential.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453823
Funder
Australian Research Council
Funding Amount
$445,124.00
Summary
Atomic Force Microscopy Facility for Soft Interfaces. This proposal seeks to establish a specialized atomic force microscopy facility capable of performing measurements on nanometre scales at soft interfaces. This will service the needs of and collaboration between leading researchers at the Universities of Newcastle, Melbourne, New South Wales and James Cook University. The facility will allow direct measurements of properties of the interactions between atoms, molecules and surfaces associated ....Atomic Force Microscopy Facility for Soft Interfaces. This proposal seeks to establish a specialized atomic force microscopy facility capable of performing measurements on nanometre scales at soft interfaces. This will service the needs of and collaboration between leading researchers at the Universities of Newcastle, Melbourne, New South Wales and James Cook University. The facility will allow direct measurements of properties of the interactions between atoms, molecules and surfaces associated with soft interfaces which are required for ongoing research in fluid-fluid interfaces, surfactant and polymer adsorbed layers, and biomolecules as well as to develop new processes in emerging fields of nanotechnology, biotechnology, and medical and pharmaceutical production.Read moreRead less