Discovery Early Career Researcher Award - Grant ID: DE240100480
Funder
Australian Research Council
Funding Amount
$445,237.00
Summary
Electrolyte design for high-performance, sustainable sodium batteries. This project aims to develop sustainable high-performance sodium batteries by investigating new non-flammable and safe electrolyte chemistries. The project will generate knowledge in materials chemistry for battery electrolytes that will underpin improvements in battery technology and help to move society towards a zero-carbon economy. The outcomes will provide materials suitable for prototyping reliable, safe and sustainable ....Electrolyte design for high-performance, sustainable sodium batteries. This project aims to develop sustainable high-performance sodium batteries by investigating new non-flammable and safe electrolyte chemistries. The project will generate knowledge in materials chemistry for battery electrolytes that will underpin improvements in battery technology and help to move society towards a zero-carbon economy. The outcomes will provide materials suitable for prototyping reliable, safe and sustainable batteries in Australia and enhance research collaborations with local and international industry partners. These advances will contribute to reliable, affordable, and sustainable energy storage systems, positioning Australia at the forefront of advanced battery research.Read moreRead less
Design of novel polymer electrolytes for solid state sodium batteries. Solid-state sodium-ion batteries can provide a cheaper, safer, and greener alternative solution to store energy. This project aims to investigate the design of advanced polymer electrolyte materials to address the challenge for the development of all solid-state sodium batteries. New understandings in polymer chemistry, interfacial properties and cell performance will be gained through co-active approaches combining molecular ....Design of novel polymer electrolytes for solid state sodium batteries. Solid-state sodium-ion batteries can provide a cheaper, safer, and greener alternative solution to store energy. This project aims to investigate the design of advanced polymer electrolyte materials to address the challenge for the development of all solid-state sodium batteries. New understandings in polymer chemistry, interfacial properties and cell performance will be gained through co-active approaches combining molecular simulations, experimental characterizations, and battery prototyping. This project will provide significant benefits in developing new functional materials, new knowledge, and advanced battery techniques, benefiting Australia’s clean energy storage sector.Read moreRead less
Many of the most serious diseases of Western societies including obesity, Type 2 diabetes, cancer growth and metastasis and cardiovascular disease have metabolic dimensions. The enzyme AMPK regulates cellular and whole body energy homeostasis by coordinating metabolic pathways to balance energy demand with nutrient supply. We are studying the structure and function of AMPK with the aim of better treating metabolic diseases.
Zwitterion-based electrolytes for advanced energy technologies. This research aims to develop a new class of electrolyte that is safer, non-flammable and designed to enable excellent performance of high energy batteries made with either sodium or lithium. Through the synthesis of new electrolyte structures that are designed to improve stability and electrochemical properties, and using a range of analysis techniques to understand the material properties, the project aims to solve some of the saf ....Zwitterion-based electrolytes for advanced energy technologies. This research aims to develop a new class of electrolyte that is safer, non-flammable and designed to enable excellent performance of high energy batteries made with either sodium or lithium. Through the synthesis of new electrolyte structures that are designed to improve stability and electrochemical properties, and using a range of analysis techniques to understand the material properties, the project aims to solve some of the safety and performance problems that plague existing electrolytes. Expected benefits include new functional energy materials for safer, more reliable energy storage technologies, plus research training, collaborations and materials development capabilities to help position Australia as a global leader in this field.Read moreRead less
Signaling Pathways To Enhance Potency Of AMPK-targeting Drugs
Funder
National Health and Medical Research Council
Funding Amount
$661,966.00
Summary
Sedentary lifestyles and consumption of high energy foods has led to epidemics of obesity-related metabolic diseases that place enormous financial and medical burden on the Australian economy. An attractive drug target to treat these diseases is AMP-activated protein kinase (AMPK) which functions as both a cellular fuel gauge and co-ordinator of whole-body metabolism. Our goal is to improve AMPK drug potency by identifying novel processes that sensitize AMPK to drugs.
ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Genomic Analysis Of DNA Binding And Gene Regulation By The Chromatin Remodelling Factor UBF
Funder
National Health and Medical Research Council
Funding Amount
$624,254.00
Summary
Synthesis of ribosomes, the cellular protein synthetic machinery, is the major anabolic event of a growing cell and is frequently dysregulated during disease such as cancer. This grant will examine a protein termed UBF that we think plays an important role in orchestrating the cellular response to dysregulated ribosome biogenesis. By understanding how UBF functions we hope to uncover novel therapeutic approaches to treat diseases associated with ribosome stress .
Developing new tools for chemical biology. We will develop new synthetic strategies to support the development of small molecule chemical probes that bind with high affinity and specificity to a target protein. Such chemical probes are invaluable in elucidating the role of specific proteins in biological pathways. Our novel strategy aims to be rapid, efficient in its use of materials and widely applicable to a range of different protein targets. The core of our approach involves using biophysica ....Developing new tools for chemical biology. We will develop new synthetic strategies to support the development of small molecule chemical probes that bind with high affinity and specificity to a target protein. Such chemical probes are invaluable in elucidating the role of specific proteins in biological pathways. Our novel strategy aims to be rapid, efficient in its use of materials and widely applicable to a range of different protein targets. The core of our approach involves using biophysical binding assays to characterise compounds that are produced on small scale using parallel chemistry. This approach will enable better chemical probes to be developed more rapidly at lower cost than is currently possible.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100584
Funder
Australian Research Council
Funding Amount
$424,636.00
Summary
DNA Replication Stress: Characterizing ground zero for genomic instability. The overarching goal of this research is to gain insights into key underlying molecular causes of, and responses to, DNA replication stress - one of the most fundamental biological processes enabling life as we know it. I will use advanced interdisciplinary imaging techniques to directly visualize DNA replication stress structures within cells in order to better understand how cells stop this stress from progressing into ....DNA Replication Stress: Characterizing ground zero for genomic instability. The overarching goal of this research is to gain insights into key underlying molecular causes of, and responses to, DNA replication stress - one of the most fundamental biological processes enabling life as we know it. I will use advanced interdisciplinary imaging techniques to directly visualize DNA replication stress structures within cells in order to better understand how cells stop this stress from progressing into DNA damage. Insights into these processes will have the potential to improve preventative and therapeutic approaches to diseases such as cancer and neurodegeneration. Read moreRead less
Investigation and Prediction of the Novel Properties of Dendrimers. Dendrimers are a new class of highly branched polymers, which have, until now, been difficult to characterise by conventional means. This project will develop and apply molecular simulation techniques to reveal the chemical and physical properties of dendrimers and their interactions with other molecules. These novel molecules potentially have beneficial applications to areas such as drug delivery and electronic materials. Th ....Investigation and Prediction of the Novel Properties of Dendrimers. Dendrimers are a new class of highly branched polymers, which have, until now, been difficult to characterise by conventional means. This project will develop and apply molecular simulation techniques to reveal the chemical and physical properties of dendrimers and their interactions with other molecules. These novel molecules potentially have beneficial applications to areas such as drug delivery and electronic materials. The outcome of this work will assist in the exploitation of this beneficial application and will provide the basis for efficient processing.Read moreRead less