ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Developmental regulation of plant mitochondrial genome structure and copy number. Recombination is a major driving force behind mitochondrial DNA evolution and is responsible for the occurrence of cytoplasmic male sterile plants that are used by plant breeders to obtain high yield hybrids. A better understanding of the mechanisms that underlie mitochondrial and chloroplast genome maintenance and segregation will be a major fundamental scientific advance that will permit an integrated picture of ....Developmental regulation of plant mitochondrial genome structure and copy number. Recombination is a major driving force behind mitochondrial DNA evolution and is responsible for the occurrence of cytoplasmic male sterile plants that are used by plant breeders to obtain high yield hybrids. A better understanding of the mechanisms that underlie mitochondrial and chloroplast genome maintenance and segregation will be a major fundamental scientific advance that will permit an integrated picture of the interactions between the three plant genomes (nuclear, mitochondrial and chloroplastic). It is also a pre-requisite for the future manipulation of the cytoplasmic genomes leading to new ways to develop varieties with modified cytoplasms.Read moreRead less
DYRK1A As A Novel Target For Glioblastoma Therapies
Funder
National Health and Medical Research Council
Funding Amount
$620,294.00
Summary
Glioblastoma is a form of brain cancer that is currently incurable. We have discovered that switching-off an enzyme called DYRK1A (using ‘DYRK1A inhibitors’) kills glioblastoma cells. This therapeutic advantage is even greater when combined with drugs approved for other cancers. This project will develop new DYRK1A inhibitors and examine a novel combination treatment for glioblastoma patients. This could initiate a novel therapy that could significantly extend patients’ lives.
Modelling, Design and Development of a Novel Wave-Energy Converter. Australia has an abundant source of wave-energy commercially untapped due to technical limitations of current wave-energy devices. This project aims to develop a novel wave-energy converter (WEC) that integrates energy capture and electricity generation through a single mechanism. This novel WEC can overcome or significantly reduce the drawbacks of existing WECs, is compact and light-weight (about 30 times less), ensures surviva ....Modelling, Design and Development of a Novel Wave-Energy Converter. Australia has an abundant source of wave-energy commercially untapped due to technical limitations of current wave-energy devices. This project aims to develop a novel wave-energy converter (WEC) that integrates energy capture and electricity generation through a single mechanism. This novel WEC can overcome or significantly reduce the drawbacks of existing WECs, is compact and light-weight (about 30 times less), ensures survivability, and has low-cost installation and maintenance. The project expects to deliver novel theoretical results in fluid-structure interaction, control systems and electrical conversion for WECs and other applications. The WEC will be demonstrated via a tested proof-of-concept physical model.Read moreRead less
Vaporization of heavier gas oil in Fluid Catalytic Cracking risers. Fluid Catalytic Cracking (FCC) is an important refinery operation responsible for about 45 per cent of the total petrol produced. The project is aimed at improving production efficiency of Australian refineries by applying fundamental modelling to the FCC. The outcomes will enable refiners to produce cleaner fuel and decrease greenhouse gas emissions.
Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization ....Novel gas-liquid columns for liquefied natural gas (LNG) production. Novel gas-liquid columns for liquefied natural gas (LNG) production. This project aims to design distillation and absorption columns, perhaps the most important unit operations in a liquefied natural gas (LNG) plant, and whose optimization is integral to overall performance of any LNG plant. This project will use 3D printers to rapidly prototype concepts of columns and their internals, and test them using flow characterization tools and numerical models. The final outcome of the project will be a set of designs of the columns, which should be more efficient, safer and cheaper to operate, and have smaller physical and environmental footprints, thus helping the Australian LNG industry to stay globally competitive.Read moreRead less
LATERAL GENE TRANSFER, GENOME EVOLUTION AND THE EMERGENCE OF NEW DISEASES CAUSED BY FUNGAL PATHOGENS IN THE PLEOSPORALES. Normal evolution involves the transfer of genes within species. The modest variation between progeny powers natural selection. Lateral gene transfer is the movement of genetic material between species. It allows for large evolutionary steps. Although common in bacteria, it has rarely been described convincingly in higher organisms such as fungi, plants or animals. We have evi ....LATERAL GENE TRANSFER, GENOME EVOLUTION AND THE EMERGENCE OF NEW DISEASES CAUSED BY FUNGAL PATHOGENS IN THE PLEOSPORALES. Normal evolution involves the transfer of genes within species. The modest variation between progeny powers natural selection. Lateral gene transfer is the movement of genetic material between species. It allows for large evolutionary steps. Although common in bacteria, it has rarely been described convincingly in higher organisms such as fungi, plants or animals. We have evidence that one group of fungal pathogens is particularly adept at acquiring new genes that enable them to cause new diseases. We will determine the mechanism and frequency of gene transfer in this group. The work had fundamental significance in evolutionary biology, in the emergence of new diseases and in the use of genetically-modified organisms.Read moreRead less
Energetics and dynamics of solvated biologically relevant molecules using liquid microjet and ion imaging technologies. The shape of many biomolecules in solution plays a critical role in determining their biological activity and function. It is known that the bonds that form between the biomolecules and the water solvent control this shape. However, very little is known about the strength and structure of these bonds at different sites around the biomolecule. Many experiments have informed u ....Energetics and dynamics of solvated biologically relevant molecules using liquid microjet and ion imaging technologies. The shape of many biomolecules in solution plays a critical role in determining their biological activity and function. It is known that the bonds that form between the biomolecules and the water solvent control this shape. However, very little is known about the strength and structure of these bonds at different sites around the biomolecule. Many experiments have informed us about the strength of the bonds, others have told us where the bonds occur. This project will provide both pieces of information for the first time, allowing us to better understand, and therefore control, biological function. This work will assist in the development of new biotechnology processes, especially in the emerging area of proteomics.Read moreRead less
Alarm Management - Silence is Golden. This project develops novel strategies and tools that aid alarm rationalisation in all types of process plants (e.g. gas, petrochemical, mining) by extracting groupings of related alarm tags from an enormous dataset of complex process data. These groupings are used in re-aligning the alarm systems, thus overcoming problems associated with the common practice of over-alarming, which may contribute to incidents like the Longford tragedy in Victoria. The approa ....Alarm Management - Silence is Golden. This project develops novel strategies and tools that aid alarm rationalisation in all types of process plants (e.g. gas, petrochemical, mining) by extracting groupings of related alarm tags from an enormous dataset of complex process data. These groupings are used in re-aligning the alarm systems, thus overcoming problems associated with the common practice of over-alarming, which may contribute to incidents like the Longford tragedy in Victoria. The approach is cost effective and improves alarm management. It addresses economic and safety concerns of the process industry as well as concerns raised in the study commissioned by the Institute of Engineers, Australia.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100863
Funder
Australian Research Council
Funding Amount
$460,847.00
Summary
High-Efficiency, Modular and Low-Cost Hydrogen Liquefaction and Storage . Australia’s first modular hydrogen liquefaction and storage. This project aims to develop a novel multi-faceted cooling system and software to increase efficiency, lower cost, and improve the safety of hydrogen liquefaction and storage. The project will establish a new multi-disciplinary research capability in Australia and expand our fundamental knowledge to model, design, and build modular liquefaction and zero-boil-off ....High-Efficiency, Modular and Low-Cost Hydrogen Liquefaction and Storage . Australia’s first modular hydrogen liquefaction and storage. This project aims to develop a novel multi-faceted cooling system and software to increase efficiency, lower cost, and improve the safety of hydrogen liquefaction and storage. The project will establish a new multi-disciplinary research capability in Australia and expand our fundamental knowledge to model, design, and build modular liquefaction and zero-boil-off storage systems, allowing widespread distribution and usage of hydrogen. It will create a paradigm shift from traditional scale-up to modern number-up approaches. This level of innovation is crucial for Australia to lead the world in hydrogen and also enable accessible and sustainable clean energy sources for Australians.Read moreRead less