Removal of Perfluorinated Chemicals Using New Fluorinated Polymer Sorbents. Per- and polyfluoroalkyl substances (PFAS) are a family of highly persistent chemicals that are linked to a number of human diseases, however existing approaches for removal of PFAS are highly inefficient. This project aims to develop and evaluate novel, reusable polymer sorbents for effective PFAS removal. The polymer sorbents will enable efficient, selective and continuous sorption of PFAS, while maintaining excellent ....Removal of Perfluorinated Chemicals Using New Fluorinated Polymer Sorbents. Per- and polyfluoroalkyl substances (PFAS) are a family of highly persistent chemicals that are linked to a number of human diseases, however existing approaches for removal of PFAS are highly inefficient. This project aims to develop and evaluate novel, reusable polymer sorbents for effective PFAS removal. The polymer sorbents will enable efficient, selective and continuous sorption of PFAS, while maintaining excellent environmental stability for long-term implementation in practical devices. The project will develop novel polymer sorbents to revolutionize the remediation of PFAS with high technical, economic and environmental feasibility, creating a pathway to a PFAS-free world, and ultimately protecting the natural environment.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100480
Funder
Australian Research Council
Funding Amount
$445,237.00
Summary
Electrolyte design for high-performance, sustainable sodium batteries. This project aims to develop sustainable high-performance sodium batteries by investigating new non-flammable and safe electrolyte chemistries. The project will generate knowledge in materials chemistry for battery electrolytes that will underpin improvements in battery technology and help to move society towards a zero-carbon economy. The outcomes will provide materials suitable for prototyping reliable, safe and sustainable ....Electrolyte design for high-performance, sustainable sodium batteries. This project aims to develop sustainable high-performance sodium batteries by investigating new non-flammable and safe electrolyte chemistries. The project will generate knowledge in materials chemistry for battery electrolytes that will underpin improvements in battery technology and help to move society towards a zero-carbon economy. The outcomes will provide materials suitable for prototyping reliable, safe and sustainable batteries in Australia and enhance research collaborations with local and international industry partners. These advances will contribute to reliable, affordable, and sustainable energy storage systems, positioning Australia at the forefront of advanced battery research.Read moreRead less
Design of novel polymer electrolytes for solid state sodium batteries. Solid-state sodium-ion batteries can provide a cheaper, safer, and greener alternative solution to store energy. This project aims to investigate the design of advanced polymer electrolyte materials to address the challenge for the development of all solid-state sodium batteries. New understandings in polymer chemistry, interfacial properties and cell performance will be gained through co-active approaches combining molecular ....Design of novel polymer electrolytes for solid state sodium batteries. Solid-state sodium-ion batteries can provide a cheaper, safer, and greener alternative solution to store energy. This project aims to investigate the design of advanced polymer electrolyte materials to address the challenge for the development of all solid-state sodium batteries. New understandings in polymer chemistry, interfacial properties and cell performance will be gained through co-active approaches combining molecular simulations, experimental characterizations, and battery prototyping. This project will provide significant benefits in developing new functional materials, new knowledge, and advanced battery techniques, benefiting Australia’s clean energy storage sector.Read moreRead less
Zwitterion-based electrolytes for advanced energy technologies. This research aims to develop a new class of electrolyte that is safer, non-flammable and designed to enable excellent performance of high energy batteries made with either sodium or lithium. Through the synthesis of new electrolyte structures that are designed to improve stability and electrochemical properties, and using a range of analysis techniques to understand the material properties, the project aims to solve some of the saf ....Zwitterion-based electrolytes for advanced energy technologies. This research aims to develop a new class of electrolyte that is safer, non-flammable and designed to enable excellent performance of high energy batteries made with either sodium or lithium. Through the synthesis of new electrolyte structures that are designed to improve stability and electrochemical properties, and using a range of analysis techniques to understand the material properties, the project aims to solve some of the safety and performance problems that plague existing electrolytes. Expected benefits include new functional energy materials for safer, more reliable energy storage technologies, plus research training, collaborations and materials development capabilities to help position Australia as a global leader in this field.Read moreRead less
Circular RNAs As Genome Destabilisers In Human Disease
Funder
National Health and Medical Research Council
Funding Amount
$2,163,220.00
Summary
Mutation of genes are hallmarks of both cancer and neurological disorders. My research group has identified roles for circular RNAs in both these processes. Now, we must close the loop by investigating the mechanism of these processes. This will inform not only why these genes are commonly mutated, but by exploiting the highly stable circular RNAs they may provide early prognostic/diagnostic biomarkers and even represent novel therapeutic targets for cancer and Huntington’s disease.
Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develo ....Revealing molecular detail of DNA triplexes to underpin antigene technology. Variations from the classic DNA double helix structure are proposed to play key roles in a range of cellular processes, particularly gene regulation. However, the biological function and therapeutic potential of these unusual DNA structures are poorly explored, since the fundamental molecular details which govern their formation and interactions with cellular machinery are not well described. This project aims to develop innovative methods to investigate, and importantly modulate, DNA and RNA triple helix assembly, specificity and molecular interactions. Resulting insights will underpin novel approaches to gene regulation, principally in the context of designing new antibacterial agents to address the antibacterial resistance problem.Read moreRead less
Atypical femoral fractures (AFF) are uncommon, but catastrophic, complications of the anti-osteoporosis medications, bisphosphonates. We aim to identify patients either protected from, or at risk of, AFF by identifying changes in their bone geometry, structure and quality, and genes increasing risk of these fractures. In this way, these cheap and effective anti-osteoporosis treatments can be targeted to patients at the lowest risk of AFF and alternative treatments to those at highest risk.
Developing new tools for chemical biology. We will develop new synthetic strategies to support the development of small molecule chemical probes that bind with high affinity and specificity to a target protein. Such chemical probes are invaluable in elucidating the role of specific proteins in biological pathways. Our novel strategy aims to be rapid, efficient in its use of materials and widely applicable to a range of different protein targets. The core of our approach involves using biophysica ....Developing new tools for chemical biology. We will develop new synthetic strategies to support the development of small molecule chemical probes that bind with high affinity and specificity to a target protein. Such chemical probes are invaluable in elucidating the role of specific proteins in biological pathways. Our novel strategy aims to be rapid, efficient in its use of materials and widely applicable to a range of different protein targets. The core of our approach involves using biophysical binding assays to characterise compounds that are produced on small scale using parallel chemistry. This approach will enable better chemical probes to be developed more rapidly at lower cost than is currently possible.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200100584
Funder
Australian Research Council
Funding Amount
$424,636.00
Summary
DNA Replication Stress: Characterizing ground zero for genomic instability. The overarching goal of this research is to gain insights into key underlying molecular causes of, and responses to, DNA replication stress - one of the most fundamental biological processes enabling life as we know it. I will use advanced interdisciplinary imaging techniques to directly visualize DNA replication stress structures within cells in order to better understand how cells stop this stress from progressing into ....DNA Replication Stress: Characterizing ground zero for genomic instability. The overarching goal of this research is to gain insights into key underlying molecular causes of, and responses to, DNA replication stress - one of the most fundamental biological processes enabling life as we know it. I will use advanced interdisciplinary imaging techniques to directly visualize DNA replication stress structures within cells in order to better understand how cells stop this stress from progressing into DNA damage. Insights into these processes will have the potential to improve preventative and therapeutic approaches to diseases such as cancer and neurodegeneration. Read moreRead less
The Social Life of Death. This project aims to investigate experiences of death, dying and bereavement amidst rapid social, economic and political transformation. In the wake of COVID19, and as Australia’s anticipated ‘death boom’ approaches, how to foster good deaths has never been more uncertain, nor more urgent. Drawing on innovative methods and socio-cultural theory, and working in partnership with families and communities, this project aims to generate new knowledge to better inform and imp ....The Social Life of Death. This project aims to investigate experiences of death, dying and bereavement amidst rapid social, economic and political transformation. In the wake of COVID19, and as Australia’s anticipated ‘death boom’ approaches, how to foster good deaths has never been more uncertain, nor more urgent. Drawing on innovative methods and socio-cultural theory, and working in partnership with families and communities, this project aims to generate new knowledge to better inform and improve policy and spark cultural renewal around the end of life. Expected outcomes include setting the international benchmark for novel scholarly understandings of death, dying and bereavement, and centring community voices in addressing contemporary challenges to dying well.
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