REGULATION OF RYANODINE RECEPTOR CALCIUM CHANNELS BY THE CALCIUM BINDING PROTEIN CALSEQUESTRIN. The project is to examine the functional interaction between two proteins in skeletal muscle that are essential for Ca2+ regulation and hence contraction, respiration and movement in all vertebrate species. One protein, the ryanodine receptor, releases calcium from stores inside the muscle cell. The other protein, calsequestrin, binds and sequesters calcium ions. We have recently discovered that th ....REGULATION OF RYANODINE RECEPTOR CALCIUM CHANNELS BY THE CALCIUM BINDING PROTEIN CALSEQUESTRIN. The project is to examine the functional interaction between two proteins in skeletal muscle that are essential for Ca2+ regulation and hence contraction, respiration and movement in all vertebrate species. One protein, the ryanodine receptor, releases calcium from stores inside the muscle cell. The other protein, calsequestrin, binds and sequesters calcium ions. We have recently discovered that the proteins also bind to each other and that calsequestrin regulates Ca2+ release from the stores through the ryanodine receptor ion channel. This regulation is likely to be important in conserving store calcium during stress or fatigue.Read moreRead less
Supramolecular Assemblies as Nanoscale Devices to Control Chemical and Physical Processes. The aims of this project are: i) to develop molecular reaction vessels to enhance the rates and control the outcomes of chemical processes; ii) to design and construct supramolecular species with a range of topologies; and iii) to explore the potential use of these supramolecular assemblies as thermal and photochemical switches and molecular tweezers, and as the basis for molecular machines and microelectr ....Supramolecular Assemblies as Nanoscale Devices to Control Chemical and Physical Processes. The aims of this project are: i) to develop molecular reaction vessels to enhance the rates and control the outcomes of chemical processes; ii) to design and construct supramolecular species with a range of topologies; and iii) to explore the potential use of these supramolecular assemblies as thermal and photochemical switches and molecular tweezers, and as the basis for molecular machines and microelectronic devices. The research is expected to provide new and efficient methods for bench-top and industrial scale synthesis of chemicals in water, as well as fundamental advances in nanotechnology to underpin new industries based on advanced materials.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989351
Funder
Australian Research Council
Funding Amount
$425,000.00
Summary
High Resolution Mass Spectrometry Facility. The research that will be supported by this vital infrastructure impacts on the sustainable environment through understanding the process of seed germination and the human condition through new drugs for the treatment of cancer and Parkinson's disease. Fundamental science will also be addressed particularly in the fields of photonics and the nature of interactions between matter.
Marine Natural Products as Sources of Agrochemicals - The Variolins. The aim of this project is the identification of new classes of agrochemicals with better pest resistance and environmental profiles. The proposed partnership with a major international chemical manufacturing organization will allow access to state-of-the-art techniques for the screening and development of novel compounds as agents for the control of pests that affect many major agricultural crops relevant to Australia's econo ....Marine Natural Products as Sources of Agrochemicals - The Variolins. The aim of this project is the identification of new classes of agrochemicals with better pest resistance and environmental profiles. The proposed partnership with a major international chemical manufacturing organization will allow access to state-of-the-art techniques for the screening and development of novel compounds as agents for the control of pests that affect many major agricultural crops relevant to Australia's economy. Australian graduate students will experience the operations of one of the world's biggest chemical manufacturers. The derivation of agrochemicals from marine sources will promote further recognition of the value of marine ecosystems around Australia.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989474
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Organic Synthesis and Reaction Processing Facility. Chemical synthesis is not only an important activity in its own right but one that provides compounds required in biology and physics. This enterprise is thus pivotal to many activities associated with a modern economy. Accordingly, it is vital to maintain a cutting-edge capacity in synthetic organic chemistry. The requested equipment will be assembled to create a state-of-the-art facility serving the needs of some sixty researchers engaged in ....Organic Synthesis and Reaction Processing Facility. Chemical synthesis is not only an important activity in its own right but one that provides compounds required in biology and physics. This enterprise is thus pivotal to many activities associated with a modern economy. Accordingly, it is vital to maintain a cutting-edge capacity in synthetic organic chemistry. The requested equipment will be assembled to create a state-of-the-art facility serving the needs of some sixty researchers engaged in diverse aspects of organic synthesis including those associated with the development of new antibiotics, drug delivery systems and molecular machines.Read moreRead less
Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules ....Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules being sought in the development of new therapeutic agents and/or materials. The combined application of molecular biological, microbiological and chemical synthesis techniques in a concerted manner in the one location will lead to a raft of new opportunities for the biotech and pharmaceutical industries in Australia.Read moreRead less
Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules ....Generation of Novel Fermentation Products and their Exploitation in the Synthesis of Biologically Active Organic Compounds with Therapeutic Potential. Collections of new micro-organisms and their metabolites suitable for use in the chemical synthesis programs will emerge from the proposed research. This will provide a potentially highly-valuable national resource that could serve the needs of many laboratories around Australia by allowing them to establish more direct routes to target molecules being sought in the development of new therapeutic agents and/or materials. The combined application of molecular biological, microbiological and chemical synthesis techniques in a concerted manner in the one location will lead to a raft of new opportunities for the biotech and pharmaceutical industries in Australia. Read moreRead less
gem-Dihalogenocyclopropanes as building blocks for the chemical synthesis of biologically active natural products and their analogues. New and efficient methods for the assembly of biologically active compounds will emerge from this research and thus provide materials for evaluation as potential therapeutics in the treatment of a range of pathological conditions including Alzheimer's disease and certain types of lung cancers that respond poorly to currently available treatments. The underpinning ....gem-Dihalogenocyclopropanes as building blocks for the chemical synthesis of biologically active natural products and their analogues. New and efficient methods for the assembly of biologically active compounds will emerge from this research and thus provide materials for evaluation as potential therapeutics in the treatment of a range of pathological conditions including Alzheimer's disease and certain types of lung cancers that respond poorly to currently available treatments. The underpinning methodologies are also likely to provide opportunities in other areas, including materials science. The training of a highly capable post-doctoral in chemical synthesis, an area where there is now an extraordinary and unsatisfied demand for such expertise, will be a further benefit of the proposed program of research.Read moreRead less
Protic Ionic Liquids: Design, Creation, Characterisation and Application. The project activities fall within National Research Priority 3: Frontier Technologies for Building and Transforming Australian Industries. To remain internationally competitive in the future many Australian manufacturing enterprises will need to make significant advancements in the design and processing of products at multiple length scales, including at molecular and atomic levels. The plan is to translate this projec ....Protic Ionic Liquids: Design, Creation, Characterisation and Application. The project activities fall within National Research Priority 3: Frontier Technologies for Building and Transforming Australian Industries. To remain internationally competitive in the future many Australian manufacturing enterprises will need to make significant advancements in the design and processing of products at multiple length scales, including at molecular and atomic levels. The plan is to translate this project's anticipated cutting edge research results into new high technology products that can be manufactured in Australia. Australian post-graduate students and post-doctoral fellows will be trained in the design, creation, characterisation and application of advanced materials.Read moreRead less
Discovery and applications of circular proteins. The many national benefits that will flow from this program include (i) new knowledge in plant biochemistry, peptide chemistry and protein engineering protected by a strong intellectual property position that will give Australia a competitive edge in relevant biotechnology applications; (ii) the training of a new generation of skilled researchers to drive a sustainable biotechnology sector in Australia; (iii) economic benefits from royalty returns ....Discovery and applications of circular proteins. The many national benefits that will flow from this program include (i) new knowledge in plant biochemistry, peptide chemistry and protein engineering protected by a strong intellectual property position that will give Australia a competitive edge in relevant biotechnology applications; (ii) the training of a new generation of skilled researchers to drive a sustainable biotechnology sector in Australia; (iii) economic benefits from royalty returns on drugs and agricultural products that will likely arise from the program; (iv) environment benefits due to a reduced need for chemical insecticides; and (v) social benefits due to a reduction in suffering from diseases for which drugs are developed as a result of this program.Read moreRead less