Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0238397
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
A ROBOTIC NMR SPECTROMETER FOR ACCELERATED DRUG DISCOVERY. The aim is to establish a facility that will use a robotic NMR instrument to help in the characterisation of drug-protein interactions and in the discovery of new drugs or agrichemicals. The significance is that with the wealth of new information arising on protein sequences from genomics programs there is an urgent need to accelerate the rate of discovery of ligands that bind to these proteins. Such ligands may provide useful drug lea ....A ROBOTIC NMR SPECTROMETER FOR ACCELERATED DRUG DISCOVERY. The aim is to establish a facility that will use a robotic NMR instrument to help in the characterisation of drug-protein interactions and in the discovery of new drugs or agrichemicals. The significance is that with the wealth of new information arising on protein sequences from genomics programs there is an urgent need to accelerate the rate of discovery of ligands that bind to these proteins. Such ligands may provide useful drug leads or help in defining the function of newly discovered proteins. The outcomes will be new knowledge on protein structure and function, and potentially, new bio-active molecules.Read moreRead less
New vistas in porphyrin chemistry via metal-catalyzed couplings with hydrazine derivatives. This project will address basic scientific questions and develop new substances for use in molecular electronics and cancer therapy. We will make and study entirely new molecules derived from porphyrins, which in Nature have vital roles in photosynthesis, oxygen transport and enzyme catalysis. This breakthrough research will reveal knowledge vital to the advancement of fundamental chemical science and als ....New vistas in porphyrin chemistry via metal-catalyzed couplings with hydrazine derivatives. This project will address basic scientific questions and develop new substances for use in molecular electronics and cancer therapy. We will make and study entirely new molecules derived from porphyrins, which in Nature have vital roles in photosynthesis, oxygen transport and enzyme catalysis. This breakthrough research will reveal knowledge vital to the advancement of fundamental chemical science and also offer excellent training in cutting edge research for young Australian scientists. In addition, porphyrin-like substances are used in cancer diagnosis and treatment and have properties essential for the next generation of nanoelectronic devices, and this project is aimed at these eventual outcomes.Read moreRead less
Molecular structure and function of the glycine receptor. This proposal will employ a cutting edge approach to reveal fundamental new insights into the ways that ligand-gated ion channels, and proteins in general, work. The new knowledge and technology developed here will broaden and strengthen Australia's research expertise across a number of basic scientific disciplines. The results will also have relevance to human health. Glycine receptors have an essential role in brain function and are ....Molecular structure and function of the glycine receptor. This proposal will employ a cutting edge approach to reveal fundamental new insights into the ways that ligand-gated ion channels, and proteins in general, work. The new knowledge and technology developed here will broaden and strengthen Australia's research expertise across a number of basic scientific disciplines. The results will also have relevance to human health. Glycine receptors have an essential role in brain function and are targets for anaesthetics and drugs of abuse. GlyRs are also important in modulating pain sensation by the brain. New insights into how natural agonists and drugs affect ion channel structure and function may lead to novel therapeutic opportunities and improved drug structure predictions.Read moreRead less
A new G-protein coupled receptor target for conotoxins. We aim to understand the interaction between venom components from the marine cone snail, a major source of potential drug leads, and a key receptor in nerve cell signalling. This receptor plays a role in many nervous system functions and has been proposed as a target for treating a range of diseases including pain, depression and drug addiction. It is critical that we understand this interaction so we can fully exploit the potential of the ....A new G-protein coupled receptor target for conotoxins. We aim to understand the interaction between venom components from the marine cone snail, a major source of potential drug leads, and a key receptor in nerve cell signalling. This receptor plays a role in many nervous system functions and has been proposed as a target for treating a range of diseases including pain, depression and drug addiction. It is critical that we understand this interaction so we can fully exploit the potential of these molecules as drug leads. The potential exists for multibillion dollar markets for these new drugs that could provide significant economic benefits to Australia.Read moreRead less
ARC Molecular and Materials Structure Research Network. The Network will build powerful e-Science resources for the structural sciences. Collaborative remote access will be developed for sophisticated instrumentation, including instruments planned for the Replacement Research Reactor and Australian Synchrotron. A structure database service with cross disciplinary content and versatile visualisation and analysis capabilities will further exemplify smart information use. The internet services will ....ARC Molecular and Materials Structure Research Network. The Network will build powerful e-Science resources for the structural sciences. Collaborative remote access will be developed for sophisticated instrumentation, including instruments planned for the Replacement Research Reactor and Australian Synchrotron. A structure database service with cross disciplinary content and versatile visualisation and analysis capabilities will further exemplify smart information use. The internet services will ultimately harness the Grid, enabling linkage into other national and international Grid systems. Encompassing physics, computer science, applied mathematics, chemistry and biochemistry, and catalysing interaction across these disciplines, the MMSN will impact all five National Research Priority 3 goals.Read moreRead less
Special Research Initiatives - Grant ID: SR0354691
Funder
Australian Research Council
Funding Amount
$30,000.00
Summary
A Grid Enabled Network for the Molecular and Materials Structure Sciences. The Molecular and Materials Structure Network will propel leading-edge Science by building powerful e-Science resources that will compel innovative collaborations of profound National benefit. Remote access will be developed for structure determination instruments, including the Research Reactor and Australian Synchrotron. A structure database with cross disciplinary content and powerful visualisation and analysis capabil ....A Grid Enabled Network for the Molecular and Materials Structure Sciences. The Molecular and Materials Structure Network will propel leading-edge Science by building powerful e-Science resources that will compel innovative collaborations of profound National benefit. Remote access will be developed for structure determination instruments, including the Research Reactor and Australian Synchrotron. A structure database with cross disciplinary content and powerful visualisation and analysis capabilities will exemplify "smart information use". Encompassing physics, computer science, chemistry and biochemistry, and catalysing interaction across these disciplines, the MMSN will impact all four National Research Priority 3 goals, and will be linked to other national and international Grids to become part of the emerging global Grid.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668382
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
e-Research Infrastructure for the Molecular and Materials Structure Sciences. Understanding molecular and materials structure in atomic detail is vital to a knowledge-based economy and a healthy society. The development of smart materials, nanotechnological devices, hydrogen storage materials, molecular switches, magnets and sensors, for example, depends on knowledge of three-dimensional atomic structure. Cures for illnesses such as SARS, AIDS and Alzheimer's disease and understanding the aging ....e-Research Infrastructure for the Molecular and Materials Structure Sciences. Understanding molecular and materials structure in atomic detail is vital to a knowledge-based economy and a healthy society. The development of smart materials, nanotechnological devices, hydrogen storage materials, molecular switches, magnets and sensors, for example, depends on knowledge of three-dimensional atomic structure. Cures for illnesses such as SARS, AIDS and Alzheimer's disease and understanding the aging process depends on knowledge of biomolecular structure. The deployment and development of automation-enhanced remote access to structural instruments through the web will greatly enhance Australian structure-based research, and make this science accessible to the public. Read moreRead less
Enhancement of plant proteinase inhibitors for the protection of crop plants against insect attack. The aim of this project is to characterise the interactions between various known plant proteinase inhibitors and the major digestive enzymes of insects by structural and dynamic studies and to utilise mutational studies to design new inhibitors that more effectively bind to target proteinases. The outcomes will be the knowledge to design specific inhibitors to give optimal inhibition of specific ....Enhancement of plant proteinase inhibitors for the protection of crop plants against insect attack. The aim of this project is to characterise the interactions between various known plant proteinase inhibitors and the major digestive enzymes of insects by structural and dynamic studies and to utilise mutational studies to design new inhibitors that more effectively bind to target proteinases. The outcomes will be the knowledge to design specific inhibitors to give optimal inhibition of specific insect proteinases. This knowledge will lead to novel approaches to protect economically important crops, such as cotton, from insect pests in Australia - potentially saving tens of millions of dollars per annum in chemical pesticide use and enhancing crop production in Australia and internationally.Read moreRead less