Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775481
Funder
Australian Research Council
Funding Amount
$304,000.00
Summary
X-ray Molecular Structure Elucidation Facility (MSEF). X-ray diffraction plays a key role in identification and molecular characterization. X-ray techniques are the single most widely used analytical resource in structure determination and provide invaluable information for scientists working in the fields of synthesis, nanotechnology, polymer chemistry, and protein chemistry amongst many others. The facility brings together a multidisciplinary team of scientists and provides state-of-the-art re ....X-ray Molecular Structure Elucidation Facility (MSEF). X-ray diffraction plays a key role in identification and molecular characterization. X-ray techniques are the single most widely used analytical resource in structure determination and provide invaluable information for scientists working in the fields of synthesis, nanotechnology, polymer chemistry, and protein chemistry amongst many others. The facility brings together a multidisciplinary team of scientists and provides state-of-the-art research and training facilities.Read moreRead less
Macromolecular Self-Assembly of Amyloid Fibrils. The misfolding of proteins is a key issue in public health. Common diseases, such as Alzheimer's disease, type 2 diabetes, and heart disease are associated with protein misfolding, and have a major impact on society. The use of proteins as therapeutic drugs is now common ( e.g. as vaccines, for immune disorders) but they can be rendered ineffective or harmful by protein misfolding. Through this project, we will enhance the fundamental understandin ....Macromolecular Self-Assembly of Amyloid Fibrils. The misfolding of proteins is a key issue in public health. Common diseases, such as Alzheimer's disease, type 2 diabetes, and heart disease are associated with protein misfolding, and have a major impact on society. The use of proteins as therapeutic drugs is now common ( e.g. as vaccines, for immune disorders) but they can be rendered ineffective or harmful by protein misfolding. Through this project, we will enhance the fundamental understanding of the processes of protein assembly in solution, at solid surfaces, and under shear.
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Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0453743
Funder
Australian Research Council
Funding Amount
$237,654.00
Summary
Advanced Materials Laser Characterisation Facility. A networked laser facility spanning the University of Melbourne, Monash University, the University of Adelaide, and Flinders University, will be created by integrating new laser instrumentation with existing specialised infrastructure. The facility will provide chemists at the four institutions with the necessary equipment to collaboratively investigate and optimise the properties of a diverse array of advanced materials, including nanoparticle ....Advanced Materials Laser Characterisation Facility. A networked laser facility spanning the University of Melbourne, Monash University, the University of Adelaide, and Flinders University, will be created by integrating new laser instrumentation with existing specialised infrastructure. The facility will provide chemists at the four institutions with the necessary equipment to collaboratively investigate and optimise the properties of a diverse array of advanced materials, including nanoparticles, polymers, biomaterials, and artificial photosynthetic systems. The outcome will be a world-class research network, outfitted with a suite of sophisticated techniques that are not currently available at any single university, or through any other Australian institution or consortium.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882576
Funder
Australian Research Council
Funding Amount
$588,000.00
Summary
Polymer Characterization Facility (PCF). Future development of macromolecular and biotechnologies have the potential to revolutionize everyday life. Current applications include plastics for engineering, diagnostic devices for biochemical analysis, polymer therapeutics for drug delivery and prosthesis with specific functions. The proposed facility will provide the analytical tools required to probe and develop advanced materials with application in medicine, agriculture, composites, cosmetics, ....Polymer Characterization Facility (PCF). Future development of macromolecular and biotechnologies have the potential to revolutionize everyday life. Current applications include plastics for engineering, diagnostic devices for biochemical analysis, polymer therapeutics for drug delivery and prosthesis with specific functions. The proposed facility will provide the analytical tools required to probe and develop advanced materials with application in medicine, agriculture, composites, cosmetics, communications and electronics.Read moreRead less
Novel Coatings For Steel. The aim of this project is to design coatings for steel that have high flexibility and high resistance to scatching and hardness. This will be achieved by the introduction of liquid crystalline phases in the coatings. The outcome will be a new generation of steel coatings with novel properties
Raman and synchrotron spectroscopy of nano-scale drug interactions and molecular processes in single living cells. The need for potent low-cost drugs is ever increasing, yet effective ways to screen for new drugs remain elusive. A spectroscopic approach to screening drugs in living cells would seem a logical alternative to chemically based and morphological methods that are the status quo. In this context we are developing methodology to analyse molecular target sites in single living cells for ....Raman and synchrotron spectroscopy of nano-scale drug interactions and molecular processes in single living cells. The need for potent low-cost drugs is ever increasing, yet effective ways to screen for new drugs remain elusive. A spectroscopic approach to screening drugs in living cells would seem a logical alternative to chemically based and morphological methods that are the status quo. In this context we are developing methodology to analyse molecular target sites in single living cells for two of the most devastating diseases to afflict human kind, namely malaria and cancer. New ways of rapidly screening drugs in living cells prior to clinical trials will save an enormous amount of time, money and ultimately lives.Read moreRead less
Biologically-Inspired Recognition and Processing in Colloidal Systems. The proposed research will enhance the understanding of forces and adsorption in biologically-inspired synthetic systems, and thereby create new strategies for improving selective adsorption, stabilization, coagulation, and separation. The expected outcomes are: increased understanding of chiral interactions at surfaces, a technique for rapid measurement of surface selectivity, new and better agents for chiral separation, a ....Biologically-Inspired Recognition and Processing in Colloidal Systems. The proposed research will enhance the understanding of forces and adsorption in biologically-inspired synthetic systems, and thereby create new strategies for improving selective adsorption, stabilization, coagulation, and separation. The expected outcomes are: increased understanding of chiral interactions at surfaces, a technique for rapid measurement of surface selectivity, new and better agents for chiral separation, a reduction in the use of organic pollutants, new methods for colloidal processing that will enable the preparation of new materials, and new surface coatings for increasing the useful life-time of medical implants.Read moreRead less
The development of unique cyclic polymers. The project will yield cyclic polymers with a large range of commercial and industrial applications (e.g. drug delivery, contamination clean-up, nano-wires, sensors) that will result in positive economic and social benefits for Australia. The research will lead to increased employment opportunities within the manufacturing industry and R&D, and also underpin and extend Australia's leading position in the development of innovative polymeric and advanced ....The development of unique cyclic polymers. The project will yield cyclic polymers with a large range of commercial and industrial applications (e.g. drug delivery, contamination clean-up, nano-wires, sensors) that will result in positive economic and social benefits for Australia. The research will lead to increased employment opportunities within the manufacturing industry and R&D, and also underpin and extend Australia's leading position in the development of innovative polymeric and advanced materials. The resulting materials will provide new and improved technological innovations for commercial products, delivering benefits direct to the public. Furthermore, there is potential development of spin-off companies - leading to further investment in Australian science and industry.Read moreRead less
Single molecule spectroscopy of functional luminescent materials. This project will provide new insights into the light induced processes occurring in individual molecules of potentially useful luminescent materials. The molecules to be studied include new fluorescent probes of biological and polymer systems and single light harvesting nanoparticles with applications in solar energy collection and conversion. The program of work proposed will increase our understanding of light induced chemical ....Single molecule spectroscopy of functional luminescent materials. This project will provide new insights into the light induced processes occurring in individual molecules of potentially useful luminescent materials. The molecules to be studied include new fluorescent probes of biological and polymer systems and single light harvesting nanoparticles with applications in solar energy collection and conversion. The program of work proposed will increase our understanding of light induced chemical processes and assist the design of advanced materials for photomolecular devices.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0237908
Funder
Australian Research Council
Funding Amount
$637,000.00
Summary
Mass Spectrometry Instrumentation for Therapeutic Lead Discovery. Drug discovery is reliant on the application of basic research and advanced technologies to obtain solutions to human suffering caused by diseases. This application seeks funding to support the installation of state-of-the-art mass spectrometry instrumentation at Griffith University and the University of Melbourne. The requested instrumentation will enhance high quality collaborative research programs in drug discovery and eradica ....Mass Spectrometry Instrumentation for Therapeutic Lead Discovery. Drug discovery is reliant on the application of basic research and advanced technologies to obtain solutions to human suffering caused by diseases. This application seeks funding to support the installation of state-of-the-art mass spectrometry instrumentation at Griffith University and the University of Melbourne. The requested instrumentation will enhance high quality collaborative research programs in drug discovery and eradicate significant deficiencies in research infrastructure at both institutions. Access to state-of-the-art mass spectrometry instrumentation will markedly improve our international competitiveness across a broad range of biological and chemical science disciplines.Read moreRead less