Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites ....Targeting the host lipid environment to disrupt malaria transmission. This project aims to characterise host molecules (in particular lipids) that are crucial for the transition of malaria parasites from one host to another. Malaria parasites encounter different environments upon their transition from human to the mosquito host. This project expects to generate new knowledge on physiological changes that are triggered by particular differences in micronutrient abundance that allow the parasites to survive in the new host. Anticipated outcomes include the identification of new intervention strategies and improved transmission model systems for vector-borne diseases. This gained knowledge could provide benefits to future biomedical applications by informing diagnostics or treatment of lipid associated diseases.Read moreRead less
Iron sources and cycling in the Tasman Sea. Determining factors that influence the health and vitality of coastal and open-ocean regions is crucial to maintaining marine biodiversity and the Earth's climatic balance. This research project will determine the role iron plays in influencing phytoplankton growth, which ultimately regulates the drawdown of carbon dioxide by the oceans.
A new approach to the U-series dating of fossil molluscs - a major advance for the earth and archaeological sciences. The development of a reliable method for accurately determining the age of fossil shells represents a breakthrough in the ability to date marine shoreline, lake, and other shell-bearing deposits (e.g. middens). This will present new opportunities for research of significant national benefit, particularly into the effects of climate change, including linked sea-level change and me ....A new approach to the U-series dating of fossil molluscs - a major advance for the earth and archaeological sciences. The development of a reliable method for accurately determining the age of fossil shells represents a breakthrough in the ability to date marine shoreline, lake, and other shell-bearing deposits (e.g. middens). This will present new opportunities for research of significant national benefit, particularly into the effects of climate change, including linked sea-level change and melting of ice sheets, the impact of sea-level change on coastal zones, and shifts in the amount and variability of rainfall in different regions. The method may also be used to estimate the frequency and size of large storm and tsunami events, earthquake risk, and the timing of prehistoric human migration and associated environmental impacts. Read moreRead less
Chronic Disease Outcomes And Enhanced Primary Care In Seniors: A Cross-Jurisdictional Linkage Project
Funder
National Health and Medical Research Council
Funding Amount
$1,077,766.00
Summary
This project will provide evidence on how best to use the efforts of Australian GPs to obtain better outcomes in patients aged 65+ years who suffer from chronic diseases such as diabetes, heart disease and high blood pressure, asthma and emphysema, seizures and stomach disorders. It will also examine the best way that GP visits can promote healthier ageing in all older seniors, aged 75+ years. For each disease and in older seniors, the study will be able to detect which of the following factors ....This project will provide evidence on how best to use the efforts of Australian GPs to obtain better outcomes in patients aged 65+ years who suffer from chronic diseases such as diabetes, heart disease and high blood pressure, asthma and emphysema, seizures and stomach disorders. It will also examine the best way that GP visits can promote healthier ageing in all older seniors, aged 75+ years. For each disease and in older seniors, the study will be able to detect which of the following factors are the most important for better patient health: (i) seeing a GP more times, (ii) seeing a GP at more even intervals, (iii) seeing the same GP, or (iv) seeing a GP with a lot of experience in chronic diseases. Separate investigations will be made in older people living in hostels and nursing homes, because their needs may be different. The study will also evaluate the benefits of a major change that occurred to Medicare in 1999, when GPs were paid to perform health assessments and to prepare health plans (with other health workers) for patients with chronic health problems. The results will enable this important initiative to be further improved. The study will use a unique and new Australian research facility, which has brought together health data on the entire population of WA from both the State and Commonwealth levels, including information on Medicare use, pharmaceuticals, hospital stays and deaths. The facility works in such a way as to preserve patient and GP privacy. A strong feature of this research will be the degree of involvement of a representative and voluntary group of older Australian patients who attend GP clinics, and the GPs themselves, in advising the researchers on what's important to consumers and GPs.Read moreRead less
Atmospheric CO2, global temperature, and surface ocean acidity response to fossil carbon burning - insights from an ancient analogue. Sequestration of anthropogenic CO2 emissions by the oceans and the impacts of resulting ocean acidification and greenhouse warming upon marine ecosystems are vital to understanding the course of future environmental change. This research will improve knowledge of the biological and chemical responses in the ocean to past changes in atmospheric CO2 levels and incre ....Atmospheric CO2, global temperature, and surface ocean acidity response to fossil carbon burning - insights from an ancient analogue. Sequestration of anthropogenic CO2 emissions by the oceans and the impacts of resulting ocean acidification and greenhouse warming upon marine ecosystems are vital to understanding the course of future environmental change. This research will improve knowledge of the biological and chemical responses in the ocean to past changes in atmospheric CO2 levels and increased ocean acidity. This will assist in predicting the consequences of different fossil fuel burning scenarios for climate and marine life, especially the future viability of organisms like corals, molluscs, and calcareous plankton that underpin key tourism and marine production systems.Read moreRead less
The Southern Ocean's role in determining atmospheric CO2 levels: new insights from novel biogenic silica records of seawater pH. About half the emissions from the burning of fossil fuel since the Industrial Revolution have been absorbed by the oceans. However, considerable uncertainty surrounds the consequences of and the extent to which the oceans will continue to sequester CO2 into the future. This research will improve existing limited knowledge of the key biological and related ocean process ....The Southern Ocean's role in determining atmospheric CO2 levels: new insights from novel biogenic silica records of seawater pH. About half the emissions from the burning of fossil fuel since the Industrial Revolution have been absorbed by the oceans. However, considerable uncertainty surrounds the consequences of and the extent to which the oceans will continue to sequester CO2 into the future. This research will improve existing limited knowledge of the key biological and related ocean processes that transfer CO2 between the surface and depth, and the poorly understood effects on marine ecosystems of increasing ocean acidity due to CO2 absorption. This knowledge will contribute to predicting the course of future climate change and gauging the impacts on marine life and production systems.Read moreRead less
DEEP SEA CORALS AS HIGH RESOLUTION RECORDERS OF SOUTHERN OCEAN NUTRIENT CHEMISTRY AND CIRCULATION. There is compelling evidence that the Earth has been warming dramatically since the end of the 19th century as a consequence of increasing atmospheric CO2. This study aims to understand the long-term role of the Southern Ocean as a 'store-house' for CO2, and its significance in controlling changes in the Earth's climate. We will use coral skeletons from the deep oceans as archives of ocean circu ....DEEP SEA CORALS AS HIGH RESOLUTION RECORDERS OF SOUTHERN OCEAN NUTRIENT CHEMISTRY AND CIRCULATION. There is compelling evidence that the Earth has been warming dramatically since the end of the 19th century as a consequence of increasing atmospheric CO2. This study aims to understand the long-term role of the Southern Ocean as a 'store-house' for CO2, and its significance in controlling changes in the Earth's climate. We will use coral skeletons from the deep oceans as archives of ocean circulation and nutrient levels. This information will help unravel how biological activity in the Southern Ocean has responded during previous episodes of climate change, and how this has controlled the levels of CO2 in the Earth's atmosphere. This will provide a better understanding of greenhouse warming and its effect on our future climate.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100087
Funder
Australian Research Council
Funding Amount
$328,075.00
Summary
Internal wave breaking and mixing in the ocean. This project aims to quantify turbulent mixing in the ocean using ultra-high-resolution numerical modelling. Turbulent mixing is caused by internal waves which transport energy from the ocean boundaries into the interior, where they drive mixing of cold, deep water with warmer water above. This mixing is crucial to the ocean circulation which controls the storage of heat and carbon in the ocean, but is inadequately represented in current climate mo ....Internal wave breaking and mixing in the ocean. This project aims to quantify turbulent mixing in the ocean using ultra-high-resolution numerical modelling. Turbulent mixing is caused by internal waves which transport energy from the ocean boundaries into the interior, where they drive mixing of cold, deep water with warmer water above. This mixing is crucial to the ocean circulation which controls the storage of heat and carbon in the ocean, but is inadequately represented in current climate models. The anticipated outcome of the project is an enhanced, global-ocean model incorporating an accurate description of turbulent mixing. This should provide significant benefits to the Australian community by improving the accuracy of future climate predictions.Read moreRead less
Reconstruction of anoxic and toxic conditions in Australian lakes and ancient oceans. Sustainable water quality is a critically important issue for Australia's economic and social development. To be able to predict and plan the future of Australia's lakes and estuaries, it is crucial to understand their ecological past and to determine their state prior to and post-European settlement. This project develops and applies novel methodologies to reconstruct the history of cyanobacterial blooms, eutr ....Reconstruction of anoxic and toxic conditions in Australian lakes and ancient oceans. Sustainable water quality is a critically important issue for Australia's economic and social development. To be able to predict and plan the future of Australia's lakes and estuaries, it is crucial to understand their ecological past and to determine their state prior to and post-European settlement. This project develops and applies novel methodologies to reconstruct the history of cyanobacterial blooms, eutrophication and anoxia in Australian waterways. It will help to identify human impact on water quality. The new methodologies, applied to ancient sedimentary rocks, will also yield information about the effect of environmental changes on early life on Earth, enforcing Australia's position in the study of global geochemical cycles.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989539
Funder
Australian Research Council
Funding Amount
$250,000.00
Summary
Purchase of a state-of-the-art high resolution inductively coupled plasma mass spectrometer. This new state-of-the-art mass spectrometer with enhanced capability will allow Tasmanian researchers to accurately determine the elemental composition of their samples of interest. The instrument will be extremely sensitive and will be able to detect elements to very low concentrations. It will be used to support a diverse range of local research projects of international significance, for example the ....Purchase of a state-of-the-art high resolution inductively coupled plasma mass spectrometer. This new state-of-the-art mass spectrometer with enhanced capability will allow Tasmanian researchers to accurately determine the elemental composition of their samples of interest. The instrument will be extremely sensitive and will be able to detect elements to very low concentrations. It will be used to support a diverse range of local research projects of international significance, for example the environmental assessment of clean and contaminated sites, chemical synthesis on a miniature scale using micro-chips, and the monitoring of selected elements of key importance for human health.Read moreRead less