I will determine the efficacy and safety of crystalloid resuscitation fluids in conventional models of care. This is a fundamental and unresolved question in Intensive Care Medicine and will have an impact on clinical practice worldwide. I will also consolidate and enhance a series of projects to provide the next generation of clinician-researchers with high-quality research opportunities. These include projects in sepsis, traumatic brain injury, and endocrine function in critical illness.
Delineating The Role Of Fludrocortisone And Hydrocortisone In The Management Of Patients With Septic Shock
Funder
National Health and Medical Research Council
Funding Amount
$553,664.00
Summary
Sepsis and septic shock are leading causes of morbidity and mortality globally. Steroids have been used to treat septic shock for decades. Two new trials, one using hydrocortisone vs. placebo and another using hydrocortisone plus fludrocortisone vs. placebo have produced differing results, with fludrocortisone possibly conferring a mortality benefit. My Program will investigate this evidence gap by providing critical evidence for the design and execution of a future definitive trial.
Despite advances in medical management, critical care clinicians continue to search for procedures that will improve outcomes in critically ill patients with haemorrhagic shock (a life-threatening fall in blood pressure). Shock is a consequence of an active process triggered by the brain . The proposed research aims to elucidate the precise sequence of brain events that initiate and maintain shock. We will also evaluate the effects of interventions (designed to ameliorate or reverse shock) on th ....Despite advances in medical management, critical care clinicians continue to search for procedures that will improve outcomes in critically ill patients with haemorrhagic shock (a life-threatening fall in blood pressure). Shock is a consequence of an active process triggered by the brain . The proposed research aims to elucidate the precise sequence of brain events that initiate and maintain shock. We will also evaluate the effects of interventions (designed to ameliorate or reverse shock) on the brain events that drive the shock response. The results of this research will offer, for the first time, a rational basis for devising new methods to reverse or ameliorate shock and potentially improve clinical outcomesRead moreRead less
Sepsis is a major cause of hospitalization and ICU admission in Australia population corresponding to more than 15700 new cases each year. Every year more than 3000 people die from sepsis in Australia which is greater than the annual national road toll and breast, prostate or colorectal cancer. The research outlined in this proposal to study the effect of steroids and vitamin D to improve patient’s recovery from sepsis and also understand the genetic basis behind their ability to survive sepsis.