Using Health Outcome Data From Pooled Longitudinal Studies Of Ageing To Develop Statistical And Microsimulation Models T
Funder
National Health and Medical Research Council
Funding Amount
$2,162,630.00
Summary
This project draws together data from nine Australian Longitudinal Studies of Ageing (LSAs), including 53484 participants, that will be used to identify factors capable of preventing disease, reducing ill-health, and promoting engaged and successful ageing for Australians. The focus is upon conditions that significantly contribute to the burden of disease including cognitive decline and dementia, sensory impairment, impairment in mobility and common mental disorders such as depression. Although ....This project draws together data from nine Australian Longitudinal Studies of Ageing (LSAs), including 53484 participants, that will be used to identify factors capable of preventing disease, reducing ill-health, and promoting engaged and successful ageing for Australians. The focus is upon conditions that significantly contribute to the burden of disease including cognitive decline and dementia, sensory impairment, impairment in mobility and common mental disorders such as depression. Although individual studies contain rich data on particular topics, there is only a small number of individuals in each study with specific medical conditions, or combinations of different conditions, especially at the older ages. Pooling data from nine studies will overcome this problem. This innovative and interdisciplinary study also involves development of the first Australian dynamic micro-simulation model of the health and social outcomes of the baby boomer and older cohorts. The simulation will allow for evaluation of the impact of modifying risk factors, and costs associated with different trajectories of health and ageing. Our program takes an interdisciplinary life course approach, incorporating interdependencies among demographic, behavioural, social, economic and health factors. Our multidisciplinary team and collaborative pooling of existing studies adds value and builds upon experience, as recommended in the Prime Minister's Science, Engineering and Innovation Council 2003 report. The outcomes will direct health and social policy to promote health behaviour, and social and medical interventions to compress morbidity and optimize healthy ageing in Australian society over the next 40 years.Read moreRead less
Learning Software Security Analysers with Imperfect Data. This project aims to systematically investigate next-generation learning-based software security analysis to detect vulnerabilities in real-world large-scale software. The expected learning-based foundation will support the handling of imperfect data in order to provide a precise, scalable and adaptive security analysis of the critical software components, thus capturing important security vulnerabilities missed by existing approaches. Th ....Learning Software Security Analysers with Imperfect Data. This project aims to systematically investigate next-generation learning-based software security analysis to detect vulnerabilities in real-world large-scale software. The expected learning-based foundation will support the handling of imperfect data in order to provide a precise, scalable and adaptive security analysis of the critical software components, thus capturing important security vulnerabilities missed by existing approaches. The success of this project will further enhance the international competitiveness of Australian research in this important field and will benefit any Australian industry and business where software systems are deeply-rooted, such as transportation, smart homes, medical devices, defence and finance.Read moreRead less
The Effects Of Oxytocin Nasal Spray On Mechanisms Of Social-communication In Young People With Autism
Funder
National Health and Medical Research Council
Funding Amount
$191,400.00
Summary
Autism is charcterised by deficits in social behaviour and communication, and is a cause of major lifelong disability. A novel intervention, Oxytocin, enhances social communication in non-clinical populations. This project will determine whether OT improves social communication deficits characteristic of autism. This project is a critical first step towards treating a core deficit of autism.
Radiation and Ablation in Rapidly Expanding Flows. The aim of the project is to record the spectra of radiation from a region of rapidly expanding flow representative of the passage of the shock layer on a re-entry capsule from the windward to the leeward surfaces. The significance of this work is that it addresses a critical area of spacecraft where the uncertainties of our design techniques are of the order of 300 per cent in terms of surface heat transfer, and current vehicles have to use lar ....Radiation and Ablation in Rapidly Expanding Flows. The aim of the project is to record the spectra of radiation from a region of rapidly expanding flow representative of the passage of the shock layer on a re-entry capsule from the windward to the leeward surfaces. The significance of this work is that it addresses a critical area of spacecraft where the uncertainties of our design techniques are of the order of 300 per cent in terms of surface heat transfer, and current vehicles have to use large safety factors to ensure survivability. The outputs from the project will be a data base of radiative parameters which should enable accurate models of the flow to be developed, which is expected to facilitate the design of advanced spacecraft with greater safety and reliability, and with lower structural mass.Read moreRead less
Next generation garbage collection: discovery, design, and development. This project aims to improve the performance of programming languages used by millions of Australians every day, such as Java, JavaScript and PHP by developing improved memory-management algorithms. These languages use what is referred to as “garbage collection” to ensure memory is managed without data loss, but do so conservatively and consequently cause performance challenges and energy overheads. This project expects to p ....Next generation garbage collection: discovery, design, and development. This project aims to improve the performance of programming languages used by millions of Australians every day, such as Java, JavaScript and PHP by developing improved memory-management algorithms. These languages use what is referred to as “garbage collection” to ensure memory is managed without data loss, but do so conservatively and consequently cause performance challenges and energy overheads. This project expects to provide these languages with improved memory-management algorithms, and provides researchers and industry with a framework for innovation. This project will enable safe software that is more efficient on today's hardware and able to exploit emerging hardware. This project should lead to better performance and energy savings for server applications, phones, watches, and smart appliances, while ensuring memory safety.Read moreRead less
Linear Formation Interferometry for Astrophysics and New Space Technologies. This project will prototype a new type of visible and infrared light interferometry: telescopes freely moving in a line 10s of metres in length and directing their light towards a central beam combiner. This is particularly well suited to sparse aperture optical interferometry from space, which can be used to resolve angular scales much finer than the world's largest monolithic telescopes. The ground based prototype wil ....Linear Formation Interferometry for Astrophysics and New Space Technologies. This project will prototype a new type of visible and infrared light interferometry: telescopes freely moving in a line 10s of metres in length and directing their light towards a central beam combiner. This is particularly well suited to sparse aperture optical interferometry from space, which can be used to resolve angular scales much finer than the world's largest monolithic telescopes. The ground based prototype will also be able to make a several key astrophysical observations of benchmark stars and stellar systems, including making precise polarimetric measurements of dust shells around bright stars.Read moreRead less
Promoting Child and Carer Wellbeing and Placement Stability in Kinship Care. Kinship care is the fastest growing out-of-home care placement in Australia, yet least supported. This project aims to implement and evaluate an attachment and trauma-based program for kinship carers, explore its suitability for cultural adaptation for Indigenous families and co-design practical resources to promote program sustainability and trauma-informed practice. This project is Australia’s first randomised trial o ....Promoting Child and Carer Wellbeing and Placement Stability in Kinship Care. Kinship care is the fastest growing out-of-home care placement in Australia, yet least supported. This project aims to implement and evaluate an attachment and trauma-based program for kinship carers, explore its suitability for cultural adaptation for Indigenous families and co-design practical resources to promote program sustainability and trauma-informed practice. This project is Australia’s first randomised trial of a tailored program for kinship carers and expects to generate vital knowledge on evidence-based support. Via implementing an innovative program for kinship carers in statutory child protection, this project should build capacity for research-based practice and benefit family wellbeing and placement outcomes in kinship care.Read moreRead less
Uncovering The Basis Of Inflammatory And Immunodeficiency Diseases
Funder
National Health and Medical Research Council
Funding Amount
$15,718,075.00
Summary
A world-class team from 3 institutions, spanning disciplines of clinical and experimental immunology, therapeutics, signalling and genetics, will identify how immune and inflammatory responses are controlled in both health and disease. The major outcomes of this work will be the generation of new knowledge, concepts and approaches to diagnose, prevent and treat the major human health problems of autoimmune diseases, inflammation, allergy and immunodeficiency.
Technologies for space based interferometry. This project aims to develop a new method for laser displacement measurements that will be uniquely suited for use in space. These measurements will enable gravitational measurements of unprecedented accuracy. Missions such as GRACE utilise gravitational observations to provide the distribution of melting polar ice, changes in sea levels, and quantitative estimates of ground water in the world’s food bowls. The technique will also allow space-based gr ....Technologies for space based interferometry. This project aims to develop a new method for laser displacement measurements that will be uniquely suited for use in space. These measurements will enable gravitational measurements of unprecedented accuracy. Missions such as GRACE utilise gravitational observations to provide the distribution of melting polar ice, changes in sea levels, and quantitative estimates of ground water in the world’s food bowls. The technique will also allow space-based gravitational wave detectors far simpler than previous proposals. The improved performance, inherent robustness and drastically reduced complexity will enable new classes of missions that would not otherwise be possible. Read moreRead less