Environmental impact on neuroendocrine and neurobiological mechanisms: treatment strategies and mimetics for maintaining good health. The current societal climate of industrialized countries such as Australia has shifted considerable over recent decades and is now one which is highly conducive to overfeeding and reduced physical activity. As a result, the incidence of obesity has risen markedly along with an associated increase in obesity-related chronic diseases such as cardiovascular disease, ....Environmental impact on neuroendocrine and neurobiological mechanisms: treatment strategies and mimetics for maintaining good health. The current societal climate of industrialized countries such as Australia has shifted considerable over recent decades and is now one which is highly conducive to overfeeding and reduced physical activity. As a result, the incidence of obesity has risen markedly along with an associated increase in obesity-related chronic diseases such as cardiovascular disease, stroke, obstructive pulmonary disease, type II diabetes, and many types of cancers. Less is known about the psychological and behavioural sequelae of this overfeeding. Calorie restriction mimetics may not only act as a preventative intervention to help reduce the incidence and severity of these major health problems, but also impact on social behaviour.Read moreRead less
Factors influencing functional locomotion in older adults. Ageing is associated with increasing limitations of physical function such as walking. Many older people also have concurrent medical conditions which may further limit function. This project adopts a multidisciplinary approach to investigate key factors that affect the ability to perform functional tasks of everyday locomotion, such as stair climbing and obstacle avoidance, in older adults including those affected by osteoarthritis. The ....Factors influencing functional locomotion in older adults. Ageing is associated with increasing limitations of physical function such as walking. Many older people also have concurrent medical conditions which may further limit function. This project adopts a multidisciplinary approach to investigate key factors that affect the ability to perform functional tasks of everyday locomotion, such as stair climbing and obstacle avoidance, in older adults including those affected by osteoarthritis. The results will increase knowledge about the adaptability of the ageing human locomotor system in both health and disease. This will provide a theoretical foundation for creating new strategies to reduce the impact of physical degeneration in older people.Read moreRead less
The early communicative environment prior to and following cochlear implants: impact on children's early communicative and cognitive development. This research with children with cochlear implants will examine the effect on language development of being in an oral environment or one that also includes sign language. The outcomes will provide information for parents and professionals enabling informed decision about the management of the children to promote the best possible outcomes.
Understanding and preventing injury in the Australian led outdoor activity domain: a theory driven approach to injury surveillance and prevention. This project will develop, trial and validate an injury surveillance system for the Australian led outdoor activity industry. An in-depth injury incident study will then be conducted and a model of led outdoor activity injury incident causation produced. This will be used to inform future injury prevention efforts and reduce injury in this domain.
Auditory and Vestibular Ringing--Detection and theraputic interventions. Tinnitus effects up to 30% of the elderly population. To date no single suppression modality has been successful across all tinnitus sufferers. This study will apply an aural, low level, modulated, fractal suppression strategy designed to induce a "natural" olivary efferent response capable of suppressing/reducing tinnitus.
Balance disorders e.g. Meniere's Disease and nausea (seasickness) are unwanted outcomes of vestibu ....Auditory and Vestibular Ringing--Detection and theraputic interventions. Tinnitus effects up to 30% of the elderly population. To date no single suppression modality has been successful across all tinnitus sufferers. This study will apply an aural, low level, modulated, fractal suppression strategy designed to induce a "natural" olivary efferent response capable of suppressing/reducing tinnitus.
Balance disorders e.g. Meniere's Disease and nausea (seasickness) are unwanted outcomes of vestibular dysfunction/hypersensitivity. This study will apply a low level, low frequency, modulated, acoustic pressure wave designed to induce a ?natural? olivary efferent response and an end organ endolymph/perilymph balance shift. It is postulated these stimuli will reduce the effects of vestibular dysfunction/hypersensitivity.
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Healthy eating and obesity prevention for preschoolers: A randomised controlled trial. The cost to society of obesity is high from both a financial and psychosocial perspective. Australian researchers can take a lead in the prevention of obesity during the formative preschool years when prevention intervention strategies have been evaluated systematically and rigorously. This will be the first study in Australia to evaluate the impact of a healthy eating and childhood obesity prevention program ....Healthy eating and obesity prevention for preschoolers: A randomised controlled trial. The cost to society of obesity is high from both a financial and psychosocial perspective. Australian researchers can take a lead in the prevention of obesity during the formative preschool years when prevention intervention strategies have been evaluated systematically and rigorously. This will be the first study in Australia to evaluate the impact of a healthy eating and childhood obesity prevention program for parents of preschool children, regardless of weight status. The findings will assist in further developing evidence-based prevention strategies that can be rolled out extensively in the Australian community for maintenance of healthy weight gain in preschool children.Read moreRead less
Using the eye as a window to the central nervous system for improved drug testing. The annual cost of treating brain illnesses is US$250 billion. Each new drug costs about US$900 million to develop. This research will give Pfizer Pty Ltd, the project’s industry partner, a more efficient and direct way of testing whether drugs can get into and affect the brain. This will reduce the cost of drug development, which ultimately means cheaper drugs. The project will develop new technologies to put Aus ....Using the eye as a window to the central nervous system for improved drug testing. The annual cost of treating brain illnesses is US$250 billion. Each new drug costs about US$900 million to develop. This research will give Pfizer Pty Ltd, the project’s industry partner, a more efficient and direct way of testing whether drugs can get into and affect the brain. This will reduce the cost of drug development, which ultimately means cheaper drugs. The project will develop new technologies to put Australia at the forefront of neuropharmaceutical and neuroscience research. A new research platform will foster collaborations with the pharmaceutical industry both within Australia and overseas. This industrial link will promote a unique post-graduate experience by providing exposure to academic and industrial environments for Australian scientists.Read moreRead less
CogChip: development of a targeted genotyping chip for executive function. This project aims to use DNA sequencing technology to identify the genetics of executive function. Our capacities to focus on a task at hand, to filter distractions and to inhibit unwanted impulses, are collectively referred to as executive functions. Executive function varies on a continuum in the general population across the lifespan, with individual differences largely due to differences in underlying genetics. The pr ....CogChip: development of a targeted genotyping chip for executive function. This project aims to use DNA sequencing technology to identify the genetics of executive function. Our capacities to focus on a task at hand, to filter distractions and to inhibit unwanted impulses, are collectively referred to as executive functions. Executive function varies on a continuum in the general population across the lifespan, with individual differences largely due to differences in underlying genetics. The project proposes to leverage this knowledge to develop a customised genotyping chip, which may find application for prediction of individual differences in executive ability across multiple settings including education and industry. Expected outcomes for the project will include breakthrough insights into the biology of cognition, and a genetic read-out of individual differences in executive ability, which could have broad application including the potential to facilitate the targeting of cognitive, educational or workplace training for those most at risk of adverse outcomes.Read moreRead less
Sleep and speech: objectively monitoring the residual effects of sleep promoting compounds. This project will benefit the one in 11 Australians with sleep difficulties. The project will improve how the safety of drugs for insomnia are evaluated by examining the changes in our speech that occur when we are impaired. The findings are expected to reduce the cost of accidents and injuries due to impairment from sleep medications.
Nurturing Australia's Little Multilingual Minds. Despite its substantial multilingual capacity of more than 300 languages, Australia has been described as a 'graveyard for languages'. In partnering with community organisations we will facilitate polyglot early learning, commencing with Spanish and Vietnamese. Expected outcomes are a deep understanding of multilingual families’ experiences, a model to support lifespan multilingual education, and openly-accessible database of child language in her ....Nurturing Australia's Little Multilingual Minds. Despite its substantial multilingual capacity of more than 300 languages, Australia has been described as a 'graveyard for languages'. In partnering with community organisations we will facilitate polyglot early learning, commencing with Spanish and Vietnamese. Expected outcomes are a deep understanding of multilingual families’ experiences, a model to support lifespan multilingual education, and openly-accessible database of child language in heritage languages. Benefits include a pivotal contribution to early childhood education with the creation of a tailor-made, principle-based program, which will enhance children’s academic achievement, familial social and mental wellbeing, and cultural and economic opportunities for all Australians. Read moreRead less