How satiation control reward value and cue-induced appetitive behaviours. This proposal aims to identify mechanisms that control environment-driven food-seeking behaviours. It seeks to do so by using modern virally-mediated and basic behavioural as well as histological techniques in a transgenic rat to characterise novel hindbrain circuits that control these feeding behaviours. This is significant as environment-driven overeating is problematic yet underlying mechanisms are unclear. This project ....How satiation control reward value and cue-induced appetitive behaviours. This proposal aims to identify mechanisms that control environment-driven food-seeking behaviours. It seeks to do so by using modern virally-mediated and basic behavioural as well as histological techniques in a transgenic rat to characterise novel hindbrain circuits that control these feeding behaviours. This is significant as environment-driven overeating is problematic yet underlying mechanisms are unclear. This project expects to provide new knowledge on when, where and how hindbrain neurons control environment-driven food-seeking behaviours. This should provide benefits to the advancement of knowledge on the neural mechanisms of food-seeking and provide a basic science platform for future research on the study of feeding behaviours.
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A comprehensive framework for modelling the human connectome. The human brain is an extraordinarily complex network of interconnected cells. This project aims to use mathematical modelling and brain imaging to uncover key principles of network wiring in the human brain. Using an interdisciplinary approach that combines elements of neuroscience, genetics, physics, and psychology, the project will result in a new, rigorous framework for testing competing theories of brain development, the identifi ....A comprehensive framework for modelling the human connectome. The human brain is an extraordinarily complex network of interconnected cells. This project aims to use mathematical modelling and brain imaging to uncover key principles of network wiring in the human brain. Using an interdisciplinary approach that combines elements of neuroscience, genetics, physics, and psychology, the project will result in a new, rigorous framework for testing competing theories of brain development, the identification of key wiring principles for developing brains, and an understanding of how these principles shape behaviour. This work will shed new light on the developmental processes that underlie human behaviour and disease.Read moreRead less
Hippocampal regulation of goal-directed decision-making. The hippocampus is a part of the brain that is central to learning and memory yet little is known about its role in decision-making. It is the aim of this application to provide the first detailed, causal evidence of hippocampal regulation of decision-making. This is significant because many mental health disorders and dementias that involve decision-making deficits are characterised by hippocampal dysfunction, but any direct link between ....Hippocampal regulation of goal-directed decision-making. The hippocampus is a part of the brain that is central to learning and memory yet little is known about its role in decision-making. It is the aim of this application to provide the first detailed, causal evidence of hippocampal regulation of decision-making. This is significant because many mental health disorders and dementias that involve decision-making deficits are characterised by hippocampal dysfunction, but any direct link between these factors is unknown. The outcomes of the current grant will provide the first evidence of that link, thus providing deeper understanding of the neurophysiological mechanisms of these disorders, which could eventuate in the creation of more beneficial treatments. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100783
Funder
Australian Research Council
Funding Amount
$409,781.00
Summary
Music and speech as a window into the predictive brain . Prediction is fundamental to daily life, and yet we know little about how this central process works in the brain. This research program aims to provide in-depth insight into predictive processing by investigating the precise, culturally relevant, and communicative domains of music and speech. The research expects to reveal cognitive and neural correlates of “what” will occur and “when” it will occur, while exploiting the musician brain as ....Music and speech as a window into the predictive brain . Prediction is fundamental to daily life, and yet we know little about how this central process works in the brain. This research program aims to provide in-depth insight into predictive processing by investigating the precise, culturally relevant, and communicative domains of music and speech. The research expects to reveal cognitive and neural correlates of “what” will occur and “when” it will occur, while exploiting the musician brain as a model for plasticity. Expected outcomes include a multi-dimensional model of prediction and its neural markers that will lay the foundation to investigate impaired predictive processing. This should substantially benefit health and education by providing perspectives for training and rehabilitation.Read moreRead less
Australian Laureate Fellowships - Grant ID: FL160100108
Funder
Australian Research Council
Funding Amount
$2,409,738.00
Summary
How the brain creates a sense of auditory space. How the brain creates a sense of auditory space. Spatial hearing is necessary for locating the source of a sound, and critical for communication in noisy listening conditions. The object of this project is to determine how the mammalian brain, including in human listeners, represents sensitivity to interaural time differences, one of the two binaural cues, and how this representation is transformed from the brainstem to the cortex. Anticipated out ....How the brain creates a sense of auditory space. How the brain creates a sense of auditory space. Spatial hearing is necessary for locating the source of a sound, and critical for communication in noisy listening conditions. The object of this project is to determine how the mammalian brain, including in human listeners, represents sensitivity to interaural time differences, one of the two binaural cues, and how this representation is transformed from the brainstem to the cortex. Anticipated outcomes include a coherent model of binaural hearing that links cellular, systems and perceptual investigations, and an understanding of the human auditory brain that should facilitate novel technologies and interventions to improve hearing function.Read moreRead less
Modelling and manipulating brain network dynamics across the lifespan. This project aims to integrate advanced computational modelling and state-of-the-art recording techniques to generate new knowledge on the neural basis of ageing. People are said to grow wiser as they grow older, though more likely they will experience cognitive slowing and reduced memory functions that interfere with their daily lives. The anticipated goal of the project is to develop techniques to predict the personalised e ....Modelling and manipulating brain network dynamics across the lifespan. This project aims to integrate advanced computational modelling and state-of-the-art recording techniques to generate new knowledge on the neural basis of ageing. People are said to grow wiser as they grow older, though more likely they will experience cognitive slowing and reduced memory functions that interfere with their daily lives. The anticipated goal of the project is to develop techniques to predict the personalised effects of brain stimulation on the ageing brain. The outcomes of this research could significantly improve understanding of brain ageing, and advance the fields of systems neuroscience, network science, and brain stimulation.Read moreRead less
Ready, steady, go: Infant motor development and cognition. This project aims to examine the changes in and relationships between cognition and motoric abilities during infancy. The project will utilise well-established and innovative measures of memory flexibility and motor development to generate new knowledge about the complex relationship between action, perception, and cognition. The expected outcomes will provide significant benefits such as increased scientific and public knowledge on earl ....Ready, steady, go: Infant motor development and cognition. This project aims to examine the changes in and relationships between cognition and motoric abilities during infancy. The project will utilise well-established and innovative measures of memory flexibility and motor development to generate new knowledge about the complex relationship between action, perception, and cognition. The expected outcomes will provide significant benefits such as increased scientific and public knowledge on early development and an evidence base on the normal stages of infant development, relevant for health policy.Read moreRead less
Enhancing lifeguard performance: A multidisciplinary approach. This project aims to improve the timely identification of swimmers at risk of drowning by drawing on a range of theoretical, empirical, and methodological approaches from the disciplines of organisational psychology, human factors, cognitive science and computer science. Lifeguards are vital for maintaining public safety at aquatic venues, however despite their presence, fatal and non-fatal drownings occur every year with little know ....Enhancing lifeguard performance: A multidisciplinary approach. This project aims to improve the timely identification of swimmers at risk of drowning by drawing on a range of theoretical, empirical, and methodological approaches from the disciplines of organisational psychology, human factors, cognitive science and computer science. Lifeguards are vital for maintaining public safety at aquatic venues, however despite their presence, fatal and non-fatal drownings occur every year with little known about the factors that affect vigilance, scanning and sustained attention in such a complex, dynamic environment. Expected outcomes of the project include evidence-based solutions for selecting, training and maintaining the performance of lifeguards that account for both organisational and individual factors. These will improve Australia’s ability to build social capital in both urban and rural centres by providing the safest possible community swimming pools.Read moreRead less
Problematic interactions between autistic adults and the justice system. This project aims to highlight how autistic adults may fall foul of the law due to a diminished ability to recognise subtle cues in social interactions that should warn of unfolding criminal activity or deteriorating relationships with justice system personnel. Autism Spectrum Disorder has unique characteristics that may lead to unwitting involvement in crime and problematic interactions with the justice system. This projec ....Problematic interactions between autistic adults and the justice system. This project aims to highlight how autistic adults may fall foul of the law due to a diminished ability to recognise subtle cues in social interactions that should warn of unfolding criminal activity or deteriorating relationships with justice system personnel. Autism Spectrum Disorder has unique characteristics that may lead to unwitting involvement in crime and problematic interactions with the justice system. This project expects to unveil innovative research paradigms, establish a knowledge base for police and the courts, and assist in developing guidelines for remediating misunderstandings that contribute to problematic interactions with the justice system.Read moreRead less
The psychology of gridlock: Compromise, coalitions, and radicalisation. This project aims to test an innovative psychological model of collective gridlock. Using interviews, surveys, experiments, small group research, and analysis of social media data, the project aims to examine critical pathways in gridlock psychology, where opponents are locked into mutually suboptimal outcomes, unable to move forward. These pathways include the exit or self-censorship of moderates; normative pressure towards ....The psychology of gridlock: Compromise, coalitions, and radicalisation. This project aims to test an innovative psychological model of collective gridlock. Using interviews, surveys, experiments, small group research, and analysis of social media data, the project aims to examine critical pathways in gridlock psychology, where opponents are locked into mutually suboptimal outcomes, unable to move forward. These pathways include the exit or self-censorship of moderates; normative pressure towards purity and refusal to compromise; tactical choices to avoid coalitions; and radicalisation. The research aims to develop novel interventions to reduce polarisation and radicalisation, and to promote compromises, which together will help society respond more nimbly and effectively to social and environmental challenges.Read moreRead less