Signals And Noise: A Study Of The Neurocognitive Mechanisms Underpinning Habituation To Noise In Normal And Damaged Hearing
Funder
National Health and Medical Research Council
Funding Amount
$408,938.00
Summary
McLachlan and Wilson recently published the first model of hearing that combines brain structure with function. This model postulates that recognition mechanisms initiate first, and then regulate the processing of other features. This project will investigate whether recognition mechanisms enable the auditory system to adapt to repetitive (background) noise by predicting and inhibiting responses to these sounds, and any changes in these mechanisms that may accompany hearing damage and tinnitus.
Information Encoding By Temporal Structure Of Afferent Spike Trains
Funder
National Health and Medical Research Council
Funding Amount
$231,175.00
Summary
Our ability to sense, discriminate and interpret touch stimuli underpins some of the most crucial functions of the human hand that relate to object exploration and manipulation. The fundamental mechanism of how nerve impulses generated by tactile receptors are interpreted by the nervous system is not understood. Only by discovering the underlying neural encoding mechanisms can we appreciate the functional impairments in patients and learn to identify them before they become widespread and irreve ....Our ability to sense, discriminate and interpret touch stimuli underpins some of the most crucial functions of the human hand that relate to object exploration and manipulation. The fundamental mechanism of how nerve impulses generated by tactile receptors are interpreted by the nervous system is not understood. Only by discovering the underlying neural encoding mechanisms can we appreciate the functional impairments in patients and learn to identify them before they become widespread and irreversible.Read moreRead less
Probing cross modal interactions in the perception of object motion and self-motion. How the brain integrates information from the different senses is not yet understood. This project aims first, to uncover how the brain integrates sound and visual information when perceiving moving objects and second, to probe more complex sensory interactions between sound, vision, and our vestibular senses when perceiving self-motion. This project will expand Australia's knowledge base, strengthen collabora ....Probing cross modal interactions in the perception of object motion and self-motion. How the brain integrates information from the different senses is not yet understood. This project aims first, to uncover how the brain integrates sound and visual information when perceiving moving objects and second, to probe more complex sensory interactions between sound, vision, and our vestibular senses when perceiving self-motion. This project will expand Australia's knowledge base, strengthen collaborative ties between Australia and Japan, and provide unique training opportunities for Australian and Japanese students. Publication of research in top-ranking journals will further promote Australian science abroad. Results will lead to improvements in the design of human-machine interfaces in both industry and entertainment.Read moreRead less
The whisker sensory system: processing information about object features. This is a new direction for research on the whisker sensory system and will put Australia at the forefront in this competitive area. Of particular significance, it will promote cross-fertilisation among three distinct disciplines - neuroscience, animal behaviour and computational neuroscience, with implications for robotics research as well. Should the robotics potential come to fruition, Australia will be in a prime posi ....The whisker sensory system: processing information about object features. This is a new direction for research on the whisker sensory system and will put Australia at the forefront in this competitive area. Of particular significance, it will promote cross-fertilisation among three distinct disciplines - neuroscience, animal behaviour and computational neuroscience, with implications for robotics research as well. Should the robotics potential come to fruition, Australia will be in a prime position to make early inroads into an important technology-based commercial enterprise. The interdisciplinary approach has important ramifications for training Australian PhD students and postdoctoral fellows and for attracting overseas research fellows. Read moreRead less
Hearing Protection Conferred By P2X2 Receptor Signaling In The Cochlea
Funder
National Health and Medical Research Council
Funding Amount
$580,019.00
Summary
Hearing loss from noise damage and ageing is the principal sensory disability in our society. This project will determine the contribution of the P2X2 receptor to protection from noise-induced hearing loss. We have found that P2X2 knockout mice have minimal temporary threshold shift. We will investigate the physiological basis for this and determine why this mouse model has greater hearing loss with intense sound and faster age-related hearing loss compared with wildtype controls.
Mechanisms of learning at the interface between perception and action. Using the latest in brain imaging and simulator technology, this project will advance understanding of how experience shapes the visual centres of our brain. It will also support partnerships with construction, mining and health services by developing real and virtual machine interfaces and tools to enhance the outcome of simulator-based training.
Creating new methods to study structure vision. The majority of the structure within natural images is due to third to fifth order correlations between image points. Research has shown that sensitivity to this higher order structure, provides so called Structure Vision. Research has also shown that as few as three to four brain mechanisms are involved, and these may be related to the Minkowski functionals, which in turn are related to the structural and surface properties of real materials. This ....Creating new methods to study structure vision. The majority of the structure within natural images is due to third to fifth order correlations between image points. Research has shown that sensitivity to this higher order structure, provides so called Structure Vision. Research has also shown that as few as three to four brain mechanisms are involved, and these may be related to the Minkowski functionals, which in turn are related to the structural and surface properties of real materials. This project aims to build on recent discoveries of new stimuli to implement objective tests with which to study structure vision with the Partner Organisation. The project aims to also expand on realistic models of how Structure Vision may be computed by just a few coupled cortical pyramidal cells.Read moreRead less
Peripheral and central mechanisms of sensory coding and integration. The research described in this proposal seeks to provide generic answers to fundamental questions about sensory processes, the nature of perceptual experience, and how these are subserved by the nervous system. The study of inter-sensory interactions in perception has the potential to be incorporated into the development of virtual reality-type computer-based technologies. The neurophysiology research will provide basic informa ....Peripheral and central mechanisms of sensory coding and integration. The research described in this proposal seeks to provide generic answers to fundamental questions about sensory processes, the nature of perceptual experience, and how these are subserved by the nervous system. The study of inter-sensory interactions in perception has the potential to be incorporated into the development of virtual reality-type computer-based technologies. The neurophysiology research will provide basic information that has the potential to deepen our understanding, and even enhance possible treatment, of neurological conditions that involve sensory systems.Read moreRead less
The human brain has many subdivisions (�areas�) that are dedicated to vision, but in many cases their functions remain unclear. This project will study an area located deep in the brain, about which very little is known, and which appears to be affected from early stages in conditions such as Alzheimer�s disease. By understanding the patterns of electrical activity of cells in this region, and their connections with other brain areas, we hope to decipher their contribution to sensory cognition.
In the areas of the brain where visual information is processed, cells respond to the presentation of visual stimuli by changing their pattern of electrical activity. At the first level of analysis, the primary visual cortex (V1), individual cells become active only if line segments or borders of a particular orientation are present in their field of detection, which encompasses a small part of the visual scene. Cells in other visual cortical areas (the extrastriate cortex) perform more complex ....In the areas of the brain where visual information is processed, cells respond to the presentation of visual stimuli by changing their pattern of electrical activity. At the first level of analysis, the primary visual cortex (V1), individual cells become active only if line segments or borders of a particular orientation are present in their field of detection, which encompasses a small part of the visual scene. Cells in other visual cortical areas (the extrastriate cortex) perform more complex detection tasks in comparison with those in V1, which demand integration of information coming from much larger portions of the visual scene. One example of these more complex properties is the phenomenon of long-range contour integration, where our visual system groups individual line segments having similar orientations, so that they are perceived as part of the same contour. This property is reflected in the electrical responses of cells in the dorsomedial visual area (DM). How are properties such as orientation specificity and long-range contour integration created? To begin addressing this question, we will investigate correlations between the physiological properties of identified cells, the spatial distribution of their information collecting regions (dendrites), and the anatomical pathways by which they receive information from other parts of the brain. This is a basic science study aimed at determining the extent to which the anatomical structure of the brain helps define the function of individual cells and brain areas. Its primary benefit will be to increase our understanding of the mechanisms underlying all sensory processing in the brain. The knowledge obtained may also lead to developments in areas of applied research including medicine and cognitive science (for example, understanding how the brain learns to interpret visual information in early life, and how visual processing degrades with ageing).Read moreRead less