Epigenetic mechanisms regulating sex differences in fear-related learning and memory. Anxiety disorders represent an enormous burden on society and are associated with premature aging and infertility in men and women. Evidence also indicates that parental anxiety affects child development. Given that fear-related learning has an important influence on emotional health which, in turn, affects lifestyle and the aging process, an understanding of the neural mechanisms mediating sex differences in ....Epigenetic mechanisms regulating sex differences in fear-related learning and memory. Anxiety disorders represent an enormous burden on society and are associated with premature aging and infertility in men and women. Evidence also indicates that parental anxiety affects child development. Given that fear-related learning has an important influence on emotional health which, in turn, affects lifestyle and the aging process, an understanding of the neural mechanisms mediating sex differences in fear learning will enhance our ability to develop better therapeutic approaches for treating anxiety and preventing relapse, potentially through a gender-specific approach. The studies outlined in this proposal will have implications for promoting and maintaining good health.Read moreRead less
Electrophysiological correlates of verbal and visuospatial working memory. Successful interaction with the world is dependent on "working memory". This memory system holds things in mind, while relating them to the past and planning for the future. A carefully controlled task, presented on a computer screen, systematically increases the number of items to be kept in mind. Accuracy and speed of matching the items are measured. The results will contribute to a theory of what processes are used ....Electrophysiological correlates of verbal and visuospatial working memory. Successful interaction with the world is dependent on "working memory". This memory system holds things in mind, while relating them to the past and planning for the future. A carefully controlled task, presented on a computer screen, systematically increases the number of items to be kept in mind. Accuracy and speed of matching the items are measured. The results will contribute to a theory of what processes are used in working memory and how the human brain manages these processes.Read moreRead less
Exploring the link between group processes and outcomes of group psychotherapy. In Australia an estimated 20% of people suffer from mental disorders for which group psychotherapy is a treatment of choice. This project has the potential to deliver direct benefits to these patients by optimizing the way group psychotherapy is structured and delivered, thus reducing emotional suffering as well as reducing the cost of treatment. As a result, it would have tremendous implications for the treatment of ....Exploring the link between group processes and outcomes of group psychotherapy. In Australia an estimated 20% of people suffer from mental disorders for which group psychotherapy is a treatment of choice. This project has the potential to deliver direct benefits to these patients by optimizing the way group psychotherapy is structured and delivered, thus reducing emotional suffering as well as reducing the cost of treatment. As a result, it would have tremendous implications for the treatment of mental health problems nationally and internationally.Read moreRead less
Presynaptic mechanisms of general anaesthesia in the fly brain. General anaesthesia is a routine procedure for both human and veterinary surgery and for any experimental paradigms requiring immobilization of animals. By abolishing consciousness, these drugs provide practitioners with an ideal way of manipulating subjects under conditions when responsiveness might be undesirable. Understanding how manipulating synaptic release mechanisms might modulate anaesthetic potency will be valuable for eve ....Presynaptic mechanisms of general anaesthesia in the fly brain. General anaesthesia is a routine procedure for both human and veterinary surgery and for any experimental paradigms requiring immobilization of animals. By abolishing consciousness, these drugs provide practitioners with an ideal way of manipulating subjects under conditions when responsiveness might be undesirable. Understanding how manipulating synaptic release mechanisms might modulate anaesthetic potency will be valuable for eventually being able to better control the anaesthetized state in human and animal subjects. By understanding general anaesthesia across multiple levels of brain function, we will at the same time be answering fundamental questions pertaining to mechanisms of perception and awareness. Read moreRead less
Using Converging Methodologies to Understand Episodic and Semantic Memory. The use of four converging methodologies and a new objective measure of implicit/explicit memory will produce a more fundamental understanding of the relationship between pre-existing and episodic memories. The results will be relevant to the current debate over repressed and false memories. The research will also provide more stringent tests of techniques and methods that are having a large impact in applied research ....Using Converging Methodologies to Understand Episodic and Semantic Memory. The use of four converging methodologies and a new objective measure of implicit/explicit memory will produce a more fundamental understanding of the relationship between pre-existing and episodic memories. The results will be relevant to the current debate over repressed and false memories. The research will also provide more stringent tests of techniques and methods that are having a large impact in applied research on aging, drug states etc.Read moreRead less