Epigenetic mechanisms regulating sex differences in fear-related learning and memory. Anxiety disorders represent an enormous burden on society and are associated with premature aging and infertility in men and women. Evidence also indicates that parental anxiety affects child development. Given that fear-related learning has an important influence on emotional health which, in turn, affects lifestyle and the aging process, an understanding of the neural mechanisms mediating sex differences in ....Epigenetic mechanisms regulating sex differences in fear-related learning and memory. Anxiety disorders represent an enormous burden on society and are associated with premature aging and infertility in men and women. Evidence also indicates that parental anxiety affects child development. Given that fear-related learning has an important influence on emotional health which, in turn, affects lifestyle and the aging process, an understanding of the neural mechanisms mediating sex differences in fear learning will enhance our ability to develop better therapeutic approaches for treating anxiety and preventing relapse, potentially through a gender-specific approach. The studies outlined in this proposal will have implications for promoting and maintaining good health.Read moreRead less
Corpus callosum function in decision making. This project aims to investigate how the major connection between the two brain hemispheres (called the corpus callosum) is involved in higher cognitive functions such as decision making, learning, knowledge updating, and performance optimisation. New knowledge will be generated in the area of human cognition by combining computational theory with measures of cognition and brain MRI. Expected outcomes are to develop and advance computational models o ....Corpus callosum function in decision making. This project aims to investigate how the major connection between the two brain hemispheres (called the corpus callosum) is involved in higher cognitive functions such as decision making, learning, knowledge updating, and performance optimisation. New knowledge will be generated in the area of human cognition by combining computational theory with measures of cognition and brain MRI. Expected outcomes are to develop and advance computational models of human brain function and structure through interdisciplinary collaboration by combing theory and experimentation. Significant benefits will be to advance our understanding of the brain and enhance Australia's scientific capability through training and collaboration.Read moreRead less
Exploring Scanning Ultrasound (SUS), A Novel Method To Treat And Prevent Neurodegenerative Disease
Funder
National Health and Medical Research Council
Funding Amount
$765,708.00
Summary
We developed a novel scanning ultrasound (SUS) protocol that clears toxic protein aggregates and restores memory function in mouse models of Alzheimer's disease (AD), without the need for therapeutic agents. Here we aim to determine whether SUS has preventative potential, whether there are synergistic effects, and whether a therapeutic antibody combined with SUS leads to an enhanced therapeutic outcome. Together this will guide the development of an ultrasound therapy in AD patients.
Characterisation of monoaminergic transmission in Central Amygdala. This project will identify the distribution and function of dopamine, serotonin and noradrenalin receptors on the various cell types and their inputs, in the medial, lateral and capsular divisions of Central Amygdala (CeA). We will test for tonic endogenous activation of monoaminergic receptors and synaptic release from electrically stimulated fibers terminating in CeA. Using paired recordings and calcium imaging, we will invest ....Characterisation of monoaminergic transmission in Central Amygdala. This project will identify the distribution and function of dopamine, serotonin and noradrenalin receptors on the various cell types and their inputs, in the medial, lateral and capsular divisions of Central Amygdala (CeA). We will test for tonic endogenous activation of monoaminergic receptors and synaptic release from electrically stimulated fibers terminating in CeA. Using paired recordings and calcium imaging, we will investigate intracellular mechanisms underlying monoamine receptor mediated effects. These findings when correlated with published behavioural studies will provide greater understanding of the role of the divisions of CeA and the inputs they receive, in the function of the amygdala.Read moreRead less
The human mirror system and the perception of others' actions. This research will provide greater understanding of how the human mirror system operates for the perception of actions, a crucial first-step toward understanding disorders of action perception such as autism and apraxia. The research program will also contribute greatly to building national capacity in cognitive neuroscience research, using advanced brain imaging methods. The fellow actively encourages and mentors young scientists, o ....The human mirror system and the perception of others' actions. This research will provide greater understanding of how the human mirror system operates for the perception of actions, a crucial first-step toward understanding disorders of action perception such as autism and apraxia. The research program will also contribute greatly to building national capacity in cognitive neuroscience research, using advanced brain imaging methods. The fellow actively encourages and mentors young scientists, organises advanced workshops that bring brain imaging researchers around the world to Australia, and builds international collaborations based around high-field brain imaging. The Future Fellowship will substantially enhance these activities, building capacity and enhancing Australia's reputation in cognitive neurosciences.Read moreRead less
Presynaptic mechanisms of general anaesthesia in the fly brain. General anaesthesia is a routine procedure for both human and veterinary surgery and for any experimental paradigms requiring immobilization of animals. By abolishing consciousness, these drugs provide practitioners with an ideal way of manipulating subjects under conditions when responsiveness might be undesirable. Understanding how manipulating synaptic release mechanisms might modulate anaesthetic potency will be valuable for eve ....Presynaptic mechanisms of general anaesthesia in the fly brain. General anaesthesia is a routine procedure for both human and veterinary surgery and for any experimental paradigms requiring immobilization of animals. By abolishing consciousness, these drugs provide practitioners with an ideal way of manipulating subjects under conditions when responsiveness might be undesirable. Understanding how manipulating synaptic release mechanisms might modulate anaesthetic potency will be valuable for eventually being able to better control the anaesthetized state in human and animal subjects. By understanding general anaesthesia across multiple levels of brain function, we will at the same time be answering fundamental questions pertaining to mechanisms of perception and awareness. Read moreRead less
How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understandi ....How does timing affect mammalian brain development and evolution? This project aims to generate fundamental knowledge on the origin of diversity in mammalian brain circuits by studying development of marsupials and rodents. The expected outcome is to elucidate how differences in the timing, rate and sequence of development of gene expression, cell differentiation and circuit formation can relate to the origin of key evolutionary innovations in the mammalian brain. The significance of understanding the dynamics of developmental systems that shape complex brain traits includes establishing new developmental paradigms in evolutionary theory, generating new tools to investigate and manipulate brain gene expression in vivo, and the potential discovery of the causes of neurodevelopmental dysfunction.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668246
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
Advanced Cell Labelling and Imaging Facility. Understanding the genetic regulation of cellular processes such as migration, differentiation and growth is an important frontier technology with significant biomedical potential. The Australian community is facing an increasing need to provide solutions for a variety of human diseases and disorders, including birth defects, nervous system injury and stroke, and ageing-related conditions. The proposed facility will allow researchers to test in vivo g ....Advanced Cell Labelling and Imaging Facility. Understanding the genetic regulation of cellular processes such as migration, differentiation and growth is an important frontier technology with significant biomedical potential. The Australian community is facing an increasing need to provide solutions for a variety of human diseases and disorders, including birth defects, nervous system injury and stroke, and ageing-related conditions. The proposed facility will allow researchers to test in vivo gene/pharmaceutical therapies as well as to better understand the genetic regulation of normal cellular processes. Read moreRead less
How does electrical stimulation affect brain networks? This project aims to generate fundamental knowledge about links between neural mechanisms, electrical brain stimulation and brain function. The project aims to improve knowledge about transcranial direct current stimulation (tDCS) and its effects on complex human brain networks. Such knowledge is necessary to enhance the effectiveness of current stimulation protocols. Using the innovative and interdisciplinary approach, this project will pr ....How does electrical stimulation affect brain networks? This project aims to generate fundamental knowledge about links between neural mechanisms, electrical brain stimulation and brain function. The project aims to improve knowledge about transcranial direct current stimulation (tDCS) and its effects on complex human brain networks. Such knowledge is necessary to enhance the effectiveness of current stimulation protocols. Using the innovative and interdisciplinary approach, this project will provide significant benefits such as crucial mechanistic information about how tDCS modulates healthy brain function which has broad implications for research and clinical use of this technique.Read moreRead less
Network activity and the role of NMDA receptors in associative learning. The brain is the most complex machine we know, and its activity shapes every aspect our lives. Studies over decades using tools from molecular and cellular neuroscience and behavioural experiments have discovered the parts of the brain involved in learning and memory formation. Much is understood about the neural circuits that mediate learning but how memories are formed and stored are not understood. The aim of this proj ....Network activity and the role of NMDA receptors in associative learning. The brain is the most complex machine we know, and its activity shapes every aspect our lives. Studies over decades using tools from molecular and cellular neuroscience and behavioural experiments have discovered the parts of the brain involved in learning and memory formation. Much is understood about the neural circuits that mediate learning but how memories are formed and stored are not understood. The aim of this project is to understand learning and memory formation using a simple Pavlovian learning paradigm, fear conditioning. Using cutting-edge molecular tools we will label the circuits in the amygdala that mediate this learning and the nature of the memory trace. In the long term, these results may drive novel storage devices.Read moreRead less