Nanorheology: Hydrodynamic Slip in Newtonian Fluids. Understanding fluid flow across a surface is essential to a great number of technologies. For over one hundred years it has been assumed that the layer of fluid adjacent to the solid moves with the solid, this is known as the no-slip boundary condition. Recently direct force balance measurements of aqueous Newtonian solutions have indicated the presence of boundary slip. Using a newly developed nanorheology technique we will systematically inv ....Nanorheology: Hydrodynamic Slip in Newtonian Fluids. Understanding fluid flow across a surface is essential to a great number of technologies. For over one hundred years it has been assumed that the layer of fluid adjacent to the solid moves with the solid, this is known as the no-slip boundary condition. Recently direct force balance measurements of aqueous Newtonian solutions have indicated the presence of boundary slip. Using a newly developed nanorheology technique we will systematically investigate the conditions that control boundary slip. This information will be used to quantify, model and control boundary slip, progressing the fields of microfluidics, particle deposition, and colloid stability.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560758
Funder
Australian Research Council
Funding Amount
$187,000.00
Summary
Dynamics at Interfaces: a facility for the characterisation of the dynamics of structural reorganisation and adsorption at interfaces. Controlling the flow, stability, and general performance of finely dispersed materials is important in a great number of industries from cosmetics to minerals purification. These properties are often controlled by the addition of material that forms a film at the interface between the dispersed material and the solvent. We seek to develop a facility that will ena ....Dynamics at Interfaces: a facility for the characterisation of the dynamics of structural reorganisation and adsorption at interfaces. Controlling the flow, stability, and general performance of finely dispersed materials is important in a great number of industries from cosmetics to minerals purification. These properties are often controlled by the addition of material that forms a film at the interface between the dispersed material and the solvent. We seek to develop a facility that will enable the properties of this film to be characterized, in particular the rate at which the film responds to mechanical and chemical changes. With this knowledge we hope to relate the nanoscopic properties of the adsorbed film to macroscopic properties of the dispersion and be able to tune the structure of the surface film, in order to control the bulk properties of complex fluids.Read moreRead less
Characterisation of nanobubbles. Surprisingly, nano-sized bubbles have recently been found to exist in aqueous solutions. Classical theory tells us they should rapidly dissolve, yet they are stable for several days, a phenomenon which has only recently been explained. Despite this, nanobubbles are already used in cleaning processes and appear to have significant health benefits. They are being investigated in treatments for asthma and neurodegenerative diseases. In collaboration with a pharmaceu ....Characterisation of nanobubbles. Surprisingly, nano-sized bubbles have recently been found to exist in aqueous solutions. Classical theory tells us they should rapidly dissolve, yet they are stable for several days, a phenomenon which has only recently been explained. Despite this, nanobubbles are already used in cleaning processes and appear to have significant health benefits. They are being investigated in treatments for asthma and neurodegenerative diseases. In collaboration with a pharmaceutical company, the best means to produce and characterise nanobubbles will be investigated, as well as the conditions governing their stability. The project also aims to determine how the nanobubbles interact with surfaces in order to better control their properties and achieve a better understanding of these bubbles.Read moreRead less
We have discovered a single tumour factor which causes cancer cachexia, a wasting condition that is one of the worst complications of malignancy, for which there is no current effective treatment. We have developed antibodies which effectively block this condition in preclinical models and have produced human/humanised version of this. This application is to characterise these human antibodies to allow us proceed to clinical trials.
Alpha-particles linked to recombinant antibodies targeting tumour cells have potential to effectively treat tumours while minimising normal tissue side effects. We will explore a novel alpha-particle therapy approach to solid tumours, by delivering 225Ac directly into tumour cells, or into cells that support the tumour (microenvironment). This approach will hopefully result in development of a new approach to treatment of cancers that are resistant to conventional therapies.
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Innovative platforms for further enhancing security and durability of the Australian Polymer Banknote and other security documents. The polymer banknote is a symbol of world-leading Australian innovation and prosperity. The utility, durability and security of our banknotes underpins consumer confidence, economic stability and national security. Events of recent years, and opportunities and threats from rapid global information flow heighten the need to enhance and renew the many security feature ....Innovative platforms for further enhancing security and durability of the Australian Polymer Banknote and other security documents. The polymer banknote is a symbol of world-leading Australian innovation and prosperity. The utility, durability and security of our banknotes underpins consumer confidence, economic stability and national security. Events of recent years, and opportunities and threats from rapid global information flow heighten the need to enhance and renew the many security features incorporated in our currency. The novel, cost-effective security-feature technologies to be developed in this project will also contribute to increasing the substantial polymer banknote export market, enable further expansion into other, even more demanding, security documents such as passports, and provide a needed boost to our domestic manufacturing industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100090
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Surface and Colloid Characterisation Facility. Surface and colloid characterisation facility: Surface science lies at the heart of biointerface and colloid science. This facility will enable particle size, shape, distribution, surface area and charge to be measured as well as the amount of material adsorbed to interfaces, the configuration of that material and the response of the surface to stimuli such as changing pH or salinity. All these parameters influence the properties of these important ....Surface and Colloid Characterisation Facility. Surface and colloid characterisation facility: Surface science lies at the heart of biointerface and colloid science. This facility will enable particle size, shape, distribution, surface area and charge to be measured as well as the amount of material adsorbed to interfaces, the configuration of that material and the response of the surface to stimuli such as changing pH or salinity. All these parameters influence the properties of these important systems. As such this facility will underpin the research of a number of groups across three institutions over the next decade and promote collaboration between scientists with a range of complementary expertise in fields where surface science is important from biology to ionic liquids.Read moreRead less
Deciphering ion specificity in complex electrolytes . This project aims to understand how ions influence the behaviour and properties of complex electrolytes (solutions containing either multiple ions, solvent mixtures, high electrolyte concentrations or a variety of interfaces, solutes or polymers). Complex electrolytes are ubiquitous in colloidal and particle technologies and underpin industrial and natural processes. Our team will combine experiment, simulation and theory to deliver a univers ....Deciphering ion specificity in complex electrolytes . This project aims to understand how ions influence the behaviour and properties of complex electrolytes (solutions containing either multiple ions, solvent mixtures, high electrolyte concentrations or a variety of interfaces, solutes or polymers). Complex electrolytes are ubiquitous in colloidal and particle technologies and underpin industrial and natural processes. Our team will combine experiment, simulation and theory to deliver a universal framework for understanding and predicting specific ion effects in complex electrolytes. The project outcomes are expected to deliver new understanding for researchers, robust rules of thumb for technologists and a public resource for data-driven solutions in applications utilising salt solutions. Read moreRead less
Unravelling the dominant drivers of ion specificity. This project aims to understand what governs the sensitivity of many technological and biological processes to the precise nature of the salt present in solution. The term ‘ion-specific’ encompasses all the circumstances in which the influence of a salt in solution depends on the precise chemical nature of the salt, not just the electrical charge on the ions that form the salt. As such, ion-specific effects abound and have important consequenc ....Unravelling the dominant drivers of ion specificity. This project aims to understand what governs the sensitivity of many technological and biological processes to the precise nature of the salt present in solution. The term ‘ion-specific’ encompasses all the circumstances in which the influence of a salt in solution depends on the precise chemical nature of the salt, not just the electrical charge on the ions that form the salt. As such, ion-specific effects abound and have important consequences in most situations involving solutions, including cellular functions and battery technology. This project will enable us to understand and control the influence of specific ions, building on our recently described fundamental ion-specific series with colloid science experiments and quantum simulations. This project should overcome current challenges in predicting ion-specific effects leading to progress in a wide variety of applications of colloid and interface science, from sensor interfaces to self-assembly.Read moreRead less