Subunit stoichiometry and arrangement in the glycine receptor. Glycine receptors are important for nervous system function. These receptors comprise a mixture of 5 alpha and beta subunits arranged around a central ion-conducting pore. The subunit stoichiometry (i.e., numbers of alpha and beta subunits) and arrangement (i.e., subunit order) are unknown. The first aim of this project is to define these parameters using tethered subunits. The second aim is to use the tethered subunits to probe th ....Subunit stoichiometry and arrangement in the glycine receptor. Glycine receptors are important for nervous system function. These receptors comprise a mixture of 5 alpha and beta subunits arranged around a central ion-conducting pore. The subunit stoichiometry (i.e., numbers of alpha and beta subunits) and arrangement (i.e., subunit order) are unknown. The first aim of this project is to define these parameters using tethered subunits. The second aim is to use the tethered subunits to probe the structure and function of glycine and zinc binding sites at an unprecedented level of resolution. The results will provide crucial new information concerning glycine receptor structure and function.Read moreRead less
Dissection of nodule and lateral root development in the model legume Lotus japonicus. We propose to isolate and decipher the function of plant genes involved in nodule development, with the view to extend and compare this knowledge to lateral root formation. While nodulation and lateral root formation are distinct processes, they appear to share anatomical and biochemical features. Working hypothesis is that nodule formation borrowed functions from lateral root development. Our approach impleme ....Dissection of nodule and lateral root development in the model legume Lotus japonicus. We propose to isolate and decipher the function of plant genes involved in nodule development, with the view to extend and compare this knowledge to lateral root formation. While nodulation and lateral root formation are distinct processes, they appear to share anatomical and biochemical features. Working hypothesis is that nodule formation borrowed functions from lateral root development. Our approach implements T-DNA and transposon insertional mutagenesis in the model legume Lotus japonicus. The success of this project will contribute significantly to the studies of plant-microbe interaction and plant morphogenesis.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE130100211
Funder
Australian Research Council
Funding Amount
$370,045.00
Summary
Improving alcohol prevention in Aboriginal and Torres Strait Islander drug and alcohol services. This project will work with the Aboriginal and Torres Strait Islander drug and alcohol sector in Queensland to develop and test a process for improving the delivery of alcohol prevention services.
In vitro expression and crystallization of proteins from the thermohalophile, Halothermothrix orenii. The project proposal is to develop enabling state-of-the-art protein technologies for biotechnology. We will for the first time develop a rapid and high throughput technique for the expression, purification and crystallisation of proteins from the extreme thermohalophile, Halothermothrix orenii. This important break through in protein technology will assist in determining structure and function ....In vitro expression and crystallization of proteins from the thermohalophile, Halothermothrix orenii. The project proposal is to develop enabling state-of-the-art protein technologies for biotechnology. We will for the first time develop a rapid and high throughput technique for the expression, purification and crystallisation of proteins from the extreme thermohalophile, Halothermothrix orenii. This important break through in protein technology will assist in determining structure and function relationships of thermohalophilic proteins. It is expected that such an understanding together with comparative bioinformatics will assist researchers to develop "designer proteins" with improved functions for different uses in biotechnology. It is also expected that this technology will be amenable for use with other thermohalophilic microbes.Read moreRead less
Understanding And Influencing Physical Activity To Improve Population Health
Funder
National Health and Medical Research Council
Funding Amount
$4,668,376.00
Summary
Three of Australia's leading researchers on physical activity and population health will use new NHMRC program grant funding to consolidate and extend their already internationally-recognised studies. Doing regular physical activity is very important for maintaining good health. It helps to prevent weight gain, type 2 diabetes, heart disease and breast and colon cancer. Unfortunately, most Australian adults are not active enough for health benefits. Rates of overweight and obesity are increasing ....Three of Australia's leading researchers on physical activity and population health will use new NHMRC program grant funding to consolidate and extend their already internationally-recognised studies. Doing regular physical activity is very important for maintaining good health. It helps to prevent weight gain, type 2 diabetes, heart disease and breast and colon cancer. Unfortunately, most Australian adults are not active enough for health benefits. Rates of overweight and obesity are increasing rapidly; more than 50% of Australian adults are above the healthy weight range. Rates of type 2 diabetes have doubled in the past 20 years. New ideas and practical tools are therefore needed to tackle these serious ‘diseases of inactivity’. To this end, Professors Neville Owen, Adrian Bauman and Wendy Brown will bring together innovative and practically useful scientific approaches drawn from psychology, epidemiology and exercise physiology. The approach is interdisciplinary – it combines theories and methods from their individual disciplines in an innovative manner, within a public health framework. Their research to date has developed better methods for measuring people’s exercise habits and has provided new insights into how personal, social and environmental circumstances can make people less active. They have also shown how to design and deliver wide-reaching programs for different social groups and evaluated their effectiveness. Their new research program will build on and significantly extend these ideas and approaches into new areas.For example, they will develop new measures of incidental physical activity and sedentary behaviour and will develop and test new, complex community interventions.Their new program will involve in-depth study of some of the most challenging researchproblems in an important and under-researched area of public health. They will further combine their disciplines and the skills of their research team in new, creative and practical ways, to answer important research questions about physical activity and population health. These ideas and approaches will be used to identify practical ways to help more people to be more physically active.Read moreRead less
Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not re ....Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not respond to the current TNF treatments. Improved anti-TNF strategies would provide enhanced health outcomes and welcome relief to many Australians. In addition, the economic benefit of the TNF market is very substantial. Therefore the potential impact of this research is very high both for health care and economical potential.Read moreRead less
A New Window into Transgene Silencing in Plants: mechanisms of copy-number independent, 5' sequence dependent, post-transcriptional silencing in a complex polyploid. Silencing of introduced genes is a major problem limiting plant molecular improvement. Sugarcane, a complex polyploid, shows the most efficient transgene silencing ever observed in plants. Silencing operates on the RNA, depends on the upstream sequence of the gene, and is independent of copy number. Other plant species develop endop ....A New Window into Transgene Silencing in Plants: mechanisms of copy-number independent, 5' sequence dependent, post-transcriptional silencing in a complex polyploid. Silencing of introduced genes is a major problem limiting plant molecular improvement. Sugarcane, a complex polyploid, shows the most efficient transgene silencing ever observed in plants. Silencing operates on the RNA, depends on the upstream sequence of the gene, and is independent of copy number. Other plant species develop endopolyploidy with age, and show unpredictable or patchy silencing. We speculate that differential silencing is a natural control mechanism in the exploitation of polyploidy in plants. The sugarcane system provides an exceptional opportunity to identify the sequences that trigger and protect from silencing, and to develop approaches to avoid the problem.Read moreRead less
Unravelling the sub-nuclear complexity of the brain. Understanding the function of the brain is a major frontier of scientific research. The ability to increase knowledge of brain function is reliant upon the development of novel methods. This application will develop a novel approach for understanding the function of particular nerve cells. One outcome will be demonstration of the applicability of a novel method of benefit to all brain researchers. Another outcome will be increased understandin ....Unravelling the sub-nuclear complexity of the brain. Understanding the function of the brain is a major frontier of scientific research. The ability to increase knowledge of brain function is reliant upon the development of novel methods. This application will develop a novel approach for understanding the function of particular nerve cells. One outcome will be demonstration of the applicability of a novel method of benefit to all brain researchers. Another outcome will be increased understanding of one brain region that is known to contribute to the development of cardiovascular disease. It is expected that increased knowledge of brain function will lead to novel theories of brain disease and therapeutic strategies.Read moreRead less
Impacts of Banned Drinkers Register Re-introduction in Northern Territory. This project aims to investigate the impact of the re-introduction of the Banned Drinker Register in the Northern Territory, where rates of alcohol-related harm are more than twenty times that seen in other Australian states.
This interdisciplinary team will use qualitative and quantitative methods across urban and remote locations to answer complex questions about policy impact.
This Project expects to provide evidence ....Impacts of Banned Drinkers Register Re-introduction in Northern Territory. This project aims to investigate the impact of the re-introduction of the Banned Drinker Register in the Northern Territory, where rates of alcohol-related harm are more than twenty times that seen in other Australian states.
This interdisciplinary team will use qualitative and quantitative methods across urban and remote locations to answer complex questions about policy impact.
This Project expects to provide evidence to inform future policy introduction and refinement. It aims to enhance Aboriginal research capacity for investigating alcohol policy.
Benefits should include world’s best evidence on the impact of supply restriction policies on treatment needs and the massive levels of harm seen in the Northern Territory.Read moreRead less
The biology of arbovirus virulence and fitness in arthropod and vertebrate hosts in vivo. In Australia, Ross River virus (RRV) represents significant concern to human health. Between 1992-2005 more than 50,000 notifications of RRV infection have been reported. While not fatal, the disease is responsible for morbidity in the community/individual that can have both social and economic costs. The project has several national benefits. It will help elucidate whether there is any association between ....The biology of arbovirus virulence and fitness in arthropod and vertebrate hosts in vivo. In Australia, Ross River virus (RRV) represents significant concern to human health. Between 1992-2005 more than 50,000 notifications of RRV infection have been reported. While not fatal, the disease is responsible for morbidity in the community/individual that can have both social and economic costs. The project has several national benefits. It will help elucidate whether there is any association between RRV strain and increased risk of RRV transmission and/or occurrence of more severe cases of human disease. It will help develop technologies that can lead towards the identification of viral markers, which could provide new avenues in the design of novel antiviral strategies.
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