Gating and permeation in ClC channels. Chloride ion channels are essential proteins in all living cells but, compared to other channels, little is known of their structure or how this defines and controls chloride transport. We will produce both normal and structurally modified (mutant and known to cause disease) chloride channels in cultured cells by genetic engineering so that we can analyse channel function using a combination of electrophysiological and chemical methods. We expect to learn ....Gating and permeation in ClC channels. Chloride ion channels are essential proteins in all living cells but, compared to other channels, little is known of their structure or how this defines and controls chloride transport. We will produce both normal and structurally modified (mutant and known to cause disease) chloride channels in cultured cells by genetic engineering so that we can analyse channel function using a combination of electrophysiological and chemical methods. We expect to learn which channel parts are fundamental and how subtle changes in structure can alter the opening and closing of these channels and the way that chloride passes through them.Read moreRead less
Impacts of Banned Drinkers Register Re-introduction in Northern Territory. This project aims to investigate the impact of the re-introduction of the Banned Drinker Register in the Northern Territory, where rates of alcohol-related harm are more than twenty times that seen in other Australian states.
This interdisciplinary team will use qualitative and quantitative methods across urban and remote locations to answer complex questions about policy impact.
This Project expects to provide evidence ....Impacts of Banned Drinkers Register Re-introduction in Northern Territory. This project aims to investigate the impact of the re-introduction of the Banned Drinker Register in the Northern Territory, where rates of alcohol-related harm are more than twenty times that seen in other Australian states.
This interdisciplinary team will use qualitative and quantitative methods across urban and remote locations to answer complex questions about policy impact.
This Project expects to provide evidence to inform future policy introduction and refinement. It aims to enhance Aboriginal research capacity for investigating alcohol policy.
Benefits should include world’s best evidence on the impact of supply restriction policies on treatment needs and the massive levels of harm seen in the Northern Territory.Read moreRead less
Special Research Initiatives - Grant ID: SR0354715
Funder
Australian Research Council
Funding Amount
$40,000.00
Summary
The Australian Plant Nutriomics Network. The Australian Plant Nutriomics Network will link Australian scientists investigating aspects of the plant nutriome - the summation of processes that deliver nutrients and water from soil to plants. The network will establish a coordinated approach to understanding genes, proteins and metabolites involved in element acquisition and how their functions are linked to soil conditions to maximise food quality and overcome soil environmental challenges. Inter ....The Australian Plant Nutriomics Network. The Australian Plant Nutriomics Network will link Australian scientists investigating aspects of the plant nutriome - the summation of processes that deliver nutrients and water from soil to plants. The network will establish a coordinated approach to understanding genes, proteins and metabolites involved in element acquisition and how their functions are linked to soil conditions to maximise food quality and overcome soil environmental challenges. International articulation will ensure information exchange and enhance postgraduate and postdoctoral training by reciprocal visits and focused workshops. A major goal will be a strategy to integrate research using a complex systems approach to problems.Read moreRead less
Cell type-specific transgene expression to increase Fe content in cereal grains. The grains industry forms a vital part of the Australian economy and farm sector. Increased iron concentrations of wheat and other cereal grains would greatly increase their nutritional value for people worldwide, thereby increasing their market value and profitability for farmers. High iron wheat would also lower the production costs of many Australian wheat products by reducing or eliminating the need for iron for ....Cell type-specific transgene expression to increase Fe content in cereal grains. The grains industry forms a vital part of the Australian economy and farm sector. Increased iron concentrations of wheat and other cereal grains would greatly increase their nutritional value for people worldwide, thereby increasing their market value and profitability for farmers. High iron wheat would also lower the production costs of many Australian wheat products by reducing or eliminating the need for iron fortification of wheat flour. High iron cereals promote healthy development of young Australians and can improve preventative healthcare by reducing the incidence of iron deficiency anaemia and biochemical deficiency.Read moreRead less
Strengthening the evidence: how community-based Indigenous health and wellbeing interventions work to improve policy and practice. Indigenous Australians suffer high rates of premature morbidity and mortality. Despite the need for programs to improve Indigenous health and wellbeing, there is little evidence to indicate which community-based programs are effective and why they are effective. This research program addresses this 'need-evidence' gap to inform policy and practice.
Closing the gap in Aboriginal maternal and child health outcomes. This project will build the evidence base needed to design and implement effective strategies to close the gap in Aboriginal maternal and child health outcomes and reduce Indigenous disadvantage across the life course.
New Insights into the Structure and Function of Pyruvate Carboxylase. Pyruvate carboxylase plays an essential roles in insulin secretion by pancreatic islets and in normal brain function, but excess expression of this enzyme in liver and adipose tissue is associated with diabetes and obesity.
Understanding the function of each structural feature in the reaction mechanism of an enzyme is essential to designing safe and effective pharmaceuticals that are required to modulate its activity.
Th ....New Insights into the Structure and Function of Pyruvate Carboxylase. Pyruvate carboxylase plays an essential roles in insulin secretion by pancreatic islets and in normal brain function, but excess expression of this enzyme in liver and adipose tissue is associated with diabetes and obesity.
Understanding the function of each structural feature in the reaction mechanism of an enzyme is essential to designing safe and effective pharmaceuticals that are required to modulate its activity.
This project, which will use cutting edge techniques in an experimental model, seeks to characterise this important enzyme's function so that better treatments can be developed in future for diabetes and obesity.
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Evaluating the applicability of Directed Evolution to the optimisation of industrial yeast strains. The fermentation industries, particularly the wine industry, are of great economic importance to Australia. Wine exports exceed $2 billion per year. Moreover, the industry and those supporting it are major employers in regional Australia. To maintain and grow our share of the international market, Australian wine must remain competitive by increasing production efficiency, maximizing quality and k ....Evaluating the applicability of Directed Evolution to the optimisation of industrial yeast strains. The fermentation industries, particularly the wine industry, are of great economic importance to Australia. Wine exports exceed $2 billion per year. Moreover, the industry and those supporting it are major employers in regional Australia. To maintain and grow our share of the international market, Australian wine must remain competitive by increasing production efficiency, maximizing quality and keeping up with changing consumer preferences, and with minimal environmental impact. As a cornerstone to the winemaking process, the yeast is a vehicle for achieving these needs. This project will develop and evaluate a method for generation of unique yeast which are non-recombinant and which yield superior wine under modern winemaking conditions.Read moreRead less
The Kids in Communities Study: national investigation of community level effects on children's developmental outcomes. This project (a cross-disciplinary collaboration) will investigate community level factors influencing early childhood developmental outcomes using a mixed methods approach in up to 10 communities across Australia. This will result in a potential set of measures or indicators that reflect communities that are good for children.
Planning for a better life under the National Disability Insurance Scheme (NDIS). This project aims to analyse and define the experiences and expectations of people with disability in rural and remote regions. People accessing the National Disability Insurance Scheme (NDIS) are required to complete a personalised service plan, however despite these reforms, people in rural and remote communities currently experience many challenges with the scheme. Using qualitative research methods, the project ....Planning for a better life under the National Disability Insurance Scheme (NDIS). This project aims to analyse and define the experiences and expectations of people with disability in rural and remote regions. People accessing the National Disability Insurance Scheme (NDIS) are required to complete a personalised service plan, however despite these reforms, people in rural and remote communities currently experience many challenges with the scheme. Using qualitative research methods, the project will investigate people’s experiences engaging with Local Area Coordinators and Planners under the Rural and Remote Strategy 2016-2019 and Aboriginal and Torres Strait Islander Engagement Strategy. The project will provide significant outcomes for Aboriginal and non-Aboriginal people with disability in rural and remote areas, disability service providers, and government and non-government policy makers.Read moreRead less