Deciphering The Role Of Atypical DNA Methylation In Neuronal Genome Regulation And Neurological Disorders
Funder
National Health and Medical Research Council
Funding Amount
$773,484.00
Summary
This research will use a combination of genomic, biochemical and functional genomics approaches to investigate the role of the atypical mCH form of DNA methylation in neuronal genome regulation and function, and provide new insights into the role of the epigenome in healthy brain function and neural pathologies.
Transforming The Diagnosis And Management Of Severe Neurocognitive Disorders Through Genomics
Funder
National Health and Medical Research Council
Funding Amount
$2,499,330.00
Summary
Neurocognitive disorders (NCD) are one of the most common genetic conditions in our society and it results with a need for ongoing permanent care for many affected people. Until recently, only 30% of people with NCD could be diagnosed but this has changed with the availability of genomic testing where all genes can be tested at once. The use of genomics in the CRE will lead to new NCD genes being identified and this information being translated into a clinical setting.
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water ....Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water and soil should lead to deeper understanding of the dynamics, variation and transfer of genetic material within these resources’ microbial communities, strategies to manage microbial diversity, and improved productivity and long-term sustainability for these resources.Read moreRead less
Political Trust and Satisfaction with Democracy in Australia. Declining public support is one of the greatest challenges to democracy. In 2019, Australia recorded the lowest level of trust in politics on record. This project aims to understand the reasons for declining political trust and satisfaction with democracy in Australia. The project hopes to field the 2022-25 Australian Election Study to address these issues by surveying a representative sample of voters following the 2022 and 2025 Aust ....Political Trust and Satisfaction with Democracy in Australia. Declining public support is one of the greatest challenges to democracy. In 2019, Australia recorded the lowest level of trust in politics on record. This project aims to understand the reasons for declining political trust and satisfaction with democracy in Australia. The project hopes to field the 2022-25 Australian Election Study to address these issues by surveying a representative sample of voters following the 2022 and 2025 Australian federal elections, in addition to continuing a longitudinal survey started in 2016. The project wants to add to an unbroken series of publicly available data on Australian political behaviour since 1987, while also producing new insights into how individual opinions change over time.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE190100210
Funder
Australian Research Council
Funding Amount
$374,000.00
Summary
Data, digital and field: political parties and 21st century campaigning. This project aims to investigate how political parties in parliamentary democracies are responding to the digital and field revolutions in campaigning. Political parties using these campaigning modes poses challenges for electoral regulators as well as for scholars of political parties trying to understand party organisation. Using six case studies from three parliamentary democracies, the expected outcome of this project i ....Data, digital and field: political parties and 21st century campaigning. This project aims to investigate how political parties in parliamentary democracies are responding to the digital and field revolutions in campaigning. Political parties using these campaigning modes poses challenges for electoral regulators as well as for scholars of political parties trying to understand party organisation. Using six case studies from three parliamentary democracies, the expected outcome of this project is an innovative account of the implications of these changes for political parties and liberal democracy. This project will increase scholarly understanding of political parties, and inform the work of electoral regulators to ensure the integrity of election campaigns are maintained.Read moreRead less
System-level characterisation of the siphonophore, Indo-Pacific man o' war. The Indo-Pacific man o' war (bluebottle), is a cnidarian from the siphonophore order. These animals frequent Australian beaches in swarms and cause thousands of stings every year. The project proposes to profile the genome, transcriptome, epigenome, and proteome of the bluebottle to gain insight into its life cycle, its behaviour, and toxins. Expected outcomes include the generation of novel information related to bluebo ....System-level characterisation of the siphonophore, Indo-Pacific man o' war. The Indo-Pacific man o' war (bluebottle), is a cnidarian from the siphonophore order. These animals frequent Australian beaches in swarms and cause thousands of stings every year. The project proposes to profile the genome, transcriptome, epigenome, and proteome of the bluebottle to gain insight into its life cycle, its behaviour, and toxins. Expected outcomes include the generation of novel information related to bluebottle gene regulation and its toxin repertoire, which will be highly beneficial for the design of future sting treatment strategies. Given that the bluebottle is a colony made of functionally specialised polyps, this study will also provide significant novel insight into the origins and evolution of animal multicellularity.Read moreRead less
Individualising Care For Patients With Chronic Hepatitis C: Predicting Side Effects And Treatment Response Using Genomic And Proteomic Approaches.
Funder
National Health and Medical Research Council
Funding Amount
$55,575.00
Summary
Patients undergoing treatment for hepatitis C must endure a treatment characterized by unpredictable treatment side effects and uncertainty about the likelihood of cure. This project will investigate genetic predictors of treatment related side-effects and protein markers to predict treatment response. Better definition of the risks and benefits of therapy, may facilitate patients and clinicians to make more informed decisions about treatment, thus individualising treatment and potentially impro ....Patients undergoing treatment for hepatitis C must endure a treatment characterized by unpredictable treatment side effects and uncertainty about the likelihood of cure. This project will investigate genetic predictors of treatment related side-effects and protein markers to predict treatment response. Better definition of the risks and benefits of therapy, may facilitate patients and clinicians to make more informed decisions about treatment, thus individualising treatment and potentially improving the safety and efficacy of therapy.Read moreRead less
A Federation of cultures? Innovative approaches to multicultural accommodation. This project examines how state and federal governments can better protect and support the values, beliefs and cultural practices of different cultural and religious groups, especially in matters concerning family life, community identity and freedom of conscience, within a framework of respect for human rights.
Governing vs. opposition parties and the global financial crisis: Comparing the United Kingdom and Australia. The Australian Prime Minister has described the global financial crisis as the 'equivalent of a rolling national security crisis'. Our project, which examines the pressures upon political parties to adopt an adversarial approach to crises as an election approaches, benefits the nation by enhancing our understanding of how political systems cope with crisis. Should governing and oppositio ....Governing vs. opposition parties and the global financial crisis: Comparing the United Kingdom and Australia. The Australian Prime Minister has described the global financial crisis as the 'equivalent of a rolling national security crisis'. Our project, which examines the pressures upon political parties to adopt an adversarial approach to crises as an election approaches, benefits the nation by enhancing our understanding of how political systems cope with crisis. Should governing and opposition parties unite in order to tackle the national crisis and portray consensus to the outside world? Or should they continue to engage in routine adversary criticism, facilitating dialogue and providing a 'check' on a centralised response? Our research will help develop an understanding of Australia's capacity to respond to major economic threats.Read moreRead less