Genome dynamics following plastid endosymbiosis. Plastid endosymbiosis events (enslavement of an algal cell inside of a host cell to form a plastid) are difficult to pinpoint because the genomic data required for a broad array of species are rarely available. Furthermore, the classical method used to infer endosymbiotic gene transfers is being criticised. This project will elucidate the origin of chlorarachniophyte and dinoflagellate plastids and characterise the genome dynamics following endosy ....Genome dynamics following plastid endosymbiosis. Plastid endosymbiosis events (enslavement of an algal cell inside of a host cell to form a plastid) are difficult to pinpoint because the genomic data required for a broad array of species are rarely available. Furthermore, the classical method used to infer endosymbiotic gene transfers is being criticised. This project will elucidate the origin of chlorarachniophyte and dinoflagellate plastids and characterise the genome dynamics following endosymbiosis. It uses densely sampled genome data obtained with high-throughput sequencing technologies. Simulation studies will be used to evaluate methods for inferring endosymbiotic gene transfer and alignment-free methods will be used to improve phylogenomic pipelines.Read moreRead less
Novel genomic technologies to improve fertility in northern beef cattle. This project aims to develop new genomic technologies to enable accelerated improvement of cow fertility. Increased global demand for beef is driving northern Australian beef enterprises to develop innovative ways to increase productivity. A substantial industry challenge is poor fertility of cows, with weaning rates frequently less than 40%. The expected outcomes of this project are an improvement in weaning rates to enabl ....Novel genomic technologies to improve fertility in northern beef cattle. This project aims to develop new genomic technologies to enable accelerated improvement of cow fertility. Increased global demand for beef is driving northern Australian beef enterprises to develop innovative ways to increase productivity. A substantial industry challenge is poor fertility of cows, with weaning rates frequently less than 40%. The expected outcomes of this project are an improvement in weaning rates to enable accelerated genetic gain for fertility in these enterprises by delivering a low cost array, which assays thousands of DNA variants affecting fertility simultaneously. This should provide significant benefits such as a new genomic prediction method informed by gene expression data from a unique resource of Brahman cattle with exceptionally high fertility, generating significant industry benefits.Read moreRead less
Strabismus is the pathological misalignment of the eyes associated with loss of binocular vision and is one of the most common human ophthalmological disorders. Patients with comitant strabismus have full eye movements, whereas patients with incomitant strabismus have limited eye movements, which causes the angle of strabismus to vary with gaze direction. This project aims to define genetic contributors to comitant congenital strabismus.
Cellular genomic approach to the pathogenesis of multiple sclerosis. This project compares the levels of gene usage in two important immune cell types between patients with multiple sclerosis and people who do not have the disease. It aims to identify the molecular basis for the disease, in order to identify new diagnostic, preventative and treatment options.
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water ....Sequencing and assembling microbial community metagenomes in real-time. This project aims to assemble metagenomes directly from environmental samples using nanopore sequencing. Short-read approaches to metagenomics cannot assemble mixed genomes from an environmental sample, so focus on describing which species and genes are present. Long-read nanopore sequencing enables the assembly of full genomes of multiple species in a sample. Assembling complete genomes in important resources such as water and soil should lead to deeper understanding of the dynamics, variation and transfer of genetic material within these resources’ microbial communities, strategies to manage microbial diversity, and improved productivity and long-term sustainability for these resources.Read moreRead less
A Genome-wide Association Study In 2000 Glaucoma Cases With Matched Controls Using Equimoloar DNA Pools
Funder
National Health and Medical Research Council
Funding Amount
$610,267.00
Summary
Glaucoma is a common cause of loss of vision worldwide but we are unable to predict which people are at high risk of blindness. We aim to discover the genetic risk factors for glaucoma. We will use cutting edge genetic technology to assess the whole genome in thousands of patients with glaucoma. We hope to identify important new glaucoma genes, which could lead to the development of diagnostic tests and treatments which will provide the most cost-efficient ways to prevent glaucoma blindness.
Constituent power in federal constitutions. The concept of constituent power is fundamental to public law. This project aims to provide the first systematic and theoretical examination of the concept as it manifests in federations. The idea of constituent power was first developed in unitary states. Consequently, its role in federations has rarely been explored. Expected outcomes include a systematic comparative analysis of constituent power in federations and the development of a theory of plur ....Constituent power in federal constitutions. The concept of constituent power is fundamental to public law. This project aims to provide the first systematic and theoretical examination of the concept as it manifests in federations. The idea of constituent power was first developed in unitary states. Consequently, its role in federations has rarely been explored. Expected outcomes include a systematic comparative analysis of constituent power in federations and the development of a theory of pluralised constituent power. Expected benefits include the generation of insights into the constitutional foundations of federal systems (including Australia), new approaches to the interpretation of federal constitutions and mapping of pathways for legitimate constitutional reform.Read moreRead less
The world through the prism of language: a cross-linguistic view of genders, noun classes, and classifiers. Australia is one of the most multilingual and multicultural countries in the world, with several hundred indigenous and immigrant languages. Noun classification devices - ranging from gender systems in familiar Indo-European languages to numeral classifiers in Southeast Asian languages - offer a unique insight into people's categorisation of the world around them. In-depth knowledge of how ....The world through the prism of language: a cross-linguistic view of genders, noun classes, and classifiers. Australia is one of the most multilingual and multicultural countries in the world, with several hundred indigenous and immigrant languages. Noun classification devices - ranging from gender systems in familiar Indo-European languages to numeral classifiers in Southeast Asian languages - offer a unique insight into people's categorisation of the world around them. In-depth knowledge of how speakers of different languages classify objects around them will promote intercultural understanding within Australia and world-wide, allowing us to overcome potential miscommunications due to different language backgrounds, and advancing our understanding of the region and the world (within the National Priority 'Safeguarding Australia'). Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100154
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
The World Legal Information Institute European law collection: effective access to European legal information in English for Australian researchers. This facility will provide the most comprehensive collection of free access English language databases of European legal materials (both national and supra-national) and allow citations of European cases and articles to be tracked, improving Australian research in European law.