The Role Of Non-classical MHC Class I Molecules In Adaptive Immunity
Funder
National Health and Medical Research Council
Funding Amount
$443,834.00
Summary
Specialised proteins called MHC class Ia molecules (MHC-Ia) stimulate killer T cells to lyse virus infected cells. In contrast, the function of the closely related MHC-Ib is uncertain. Recent findings have demonstrated that MHC-Ib can also be recognised by T cells and this interaction is important in the control of viral infections. However, despite the similarity to MHC-Ia, it is unclear how this interaction occurs. This project aims to investigate how killer T cells recognise MHC-Ib molecules.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100121
Funder
Australian Research Council
Funding Amount
$360,000.00
Summary
Three-dimensional super-resolution nanophotonic fabrication facility. This stimulated emission depletion microscopy nanophotonic fabrication facility will be the first nanophotonic fabrication facility that is able to achieve optical resolution far beyond the diffraction limit, which will facilitate breakthroughs in cutting-edge nanotechnology research areas.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100199
Funder
Australian Research Council
Funding Amount
$367,900.00
Summary
Advanced Synthesis System for Two-Dimensional Nanomaterials. Advanced synthesis system for two-dimensional nanomaterials:
This project aims to establish the first synthesis facility in Australia for growing large-area and atomically thin two-dimensional (2-D) nanomaterials including graphene, boron nitride, metal dichalcogenides, metal oxide and nitride nanosheets. Such materials are emerging and innovative materials that possess many properties desirable for energy, electronic, biological, and ....Advanced Synthesis System for Two-Dimensional Nanomaterials. Advanced synthesis system for two-dimensional nanomaterials:
This project aims to establish the first synthesis facility in Australia for growing large-area and atomically thin two-dimensional (2-D) nanomaterials including graphene, boron nitride, metal dichalcogenides, metal oxide and nitride nanosheets. Such materials are emerging and innovative materials that possess many properties desirable for energy, electronic, biological, and environmental related applications. This facility is designed to underpin breakthrough science by providing high-quality large-sized materials to researchers for both fundamental and application research. This new synthesis capability would foster advances in the fundamental understanding of 2-D nanostructures and the development of devices with broad applications in energy conversion and storage, environmental protection, and life sciences.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101105
Funder
Australian Research Council
Funding Amount
$422,318.00
Summary
Developing Polymer Electrolytes for Operational All-Solid-State Batteries. This project aims to advance the development of safe rechargeable all-solid-state batteries (ASSBs) by innovating fluorinated block copolymers as solid-state electrolytes. ASSBs are the most promising power source for emerging energy storage goals, however, low ionic conductivity and poor long-term cycling stability are critical bottlenecks to their successful application. This project seeks to tackle these challenges by ....Developing Polymer Electrolytes for Operational All-Solid-State Batteries. This project aims to advance the development of safe rechargeable all-solid-state batteries (ASSBs) by innovating fluorinated block copolymers as solid-state electrolytes. ASSBs are the most promising power source for emerging energy storage goals, however, low ionic conductivity and poor long-term cycling stability are critical bottlenecks to their successful application. This project seeks to tackle these challenges by fabricating unique ionic conduction channels and stabilising electrode-electrolyte interfaces using fluorinated block copolymer electrolytes. The expected outcomes are new knowledge in polymer electrolytes and advancement in the commercialisation of ASSBs toward more efficient, safe and reliable energy storage technologies.Read moreRead less
Novel Statistical Methods For Genetic Epidemiology
Funder
National Health and Medical Research Council
Funding Amount
$481,505.00
Summary
We are in the midst of a genomics revolution that is transforming epidemiology, medicine and drug discovery. However, the scarcity of sophisticated statistical techniques to deal with the complicated problems inherent in genetic investigations of complex diseases is currently the critical factor limiting the success of human gene discovery programs. Statistical genetic methodology is currently one of the fastest developing areas of epidemiology. In information-intensive' areas such as genetic ep ....We are in the midst of a genomics revolution that is transforming epidemiology, medicine and drug discovery. However, the scarcity of sophisticated statistical techniques to deal with the complicated problems inherent in genetic investigations of complex diseases is currently the critical factor limiting the success of human gene discovery programs. Statistical genetic methodology is currently one of the fastest developing areas of epidemiology. In information-intensive' areas such as genetic epidemiology, genomics, and proteomics, there is a high demand for data analysis and statistical skills. WA has some world class expertise in statistical science, both in academia and in industry. However, this expertise has not yet been applied in a system way to genetic data analysis. We propose to undertake advanced methodological research in statistical genetics and bioinformatics, to produce easy-to-use and accessible software tools and resources that allow methodological advances to be accessed by the Australian research community, and to apply our new methods and tools both to specific disease research and to the developing human genome epidemiology (HuGE) enterprise in WA. These new initiatives in methodological research will draw together a number of currently separate research strands and will provide new tools and resources that will allow applied Australian programs to improve the efficiency of their research into the causes of important. Methodological development in both bioinformatics and statistical genetics are recognized international areas of need.Read moreRead less
Dhenia: A study of regionalism, population and society in Bronze Age Cyprus. The cemetery complex at Dhenia in Cyprus was in use for 2500 years, from the beginning of the Bronze Age (2,400 BCE) to the end of the Iron Age. This project is designed to sample this extensive site to assess its changing size and structure during periods of major social transformation. Comparative studies of contemporary sites will provide the basis for monitoring and explaining local, regional and island-wide relatio ....Dhenia: A study of regionalism, population and society in Bronze Age Cyprus. The cemetery complex at Dhenia in Cyprus was in use for 2500 years, from the beginning of the Bronze Age (2,400 BCE) to the end of the Iron Age. This project is designed to sample this extensive site to assess its changing size and structure during periods of major social transformation. Comparative studies of contemporary sites will provide the basis for monitoring and explaining local, regional and island-wide relationships, viewed in a context of expanding population and increasing interaction with the wider Mediterranean world. New data and approaches will contribute significantly to Cypriot archaeology and to broader archaeological theory.Read moreRead less
Development of Metal-Titania Core-Shell Nanostructures for Photocatalysis. The aim of this project is to develop innovative techniques for the synthesis of advanced nanomaterials for pollutant removal and antibacterial applications. Improving the photocatalysis efficiency of titanium oxide (TiO2) is critical in energy and environmental applications. This project aims to develop innovative strategies to prepare metal–TiO2 core-shell nanostructures, in which metals (eg gold, silver) can be used as ....Development of Metal-Titania Core-Shell Nanostructures for Photocatalysis. The aim of this project is to develop innovative techniques for the synthesis of advanced nanomaterials for pollutant removal and antibacterial applications. Improving the photocatalysis efficiency of titanium oxide (TiO2) is critical in energy and environmental applications. This project aims to develop innovative strategies to prepare metal–TiO2 core-shell nanostructures, in which metals (eg gold, silver) can be used as light absorbers for visible incident light and generate intense electromagnetic fields, thus improving efficiency.Read moreRead less
A study of the archaeology of Caucasian Iberia with implications for grazing management in Australia. This multi-disciplinary project will promote a younger generation of talented postgraduate and undergraduate students in a wide variety of fields, including archaeology, geomatic engineering, conservation of material culture, environmental and other natural sciences. The highlands of the Caucasus, located in a bioclimatic zone with a long history of alpine grazing, can also provide answers to qu ....A study of the archaeology of Caucasian Iberia with implications for grazing management in Australia. This multi-disciplinary project will promote a younger generation of talented postgraduate and undergraduate students in a wide variety of fields, including archaeology, geomatic engineering, conservation of material culture, environmental and other natural sciences. The highlands of the Caucasus, located in a bioclimatic zone with a long history of alpine grazing, can also provide answers to questions such as the effect of grazing on biodiversity and the rehabilitation of fragile ecosystems, which may inform management and conservation activities in analogous highland country in Australia. The project will also ensure that exhibitions illustrating the rich heritage of Caucasus will reach Australian shores.Read moreRead less