Symmetry and geometric structures. This is a fundamental research project in mathematics, especially concerned with the interaction between symmetry, differential equations, and geometry. Based on many classical and recently discovered instances, the aim of the project is to use symmetries to build and understand curved geometric structures from their flat counterparts.
Epigenetic Programming Of Immune Development In Utero: Role Of The Maternal Environment In The Allergy Epidemic
Funder
National Health and Medical Research Council
Funding Amount
$764,463.00
Summary
This study will provide new insights into the development of allergic disease. Specifically, we will explore the hypothesis that allergic disease and other disorders or immune dysregulation occur as a result of gene-environmental interactions in early life, and that these events begin in pregnancy when the developing fetus is still developing and most susceptible to these effects.
Special Research Initiatives - Grant ID: SR0354580
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
Sustainable Futures through Understanding Past Human Responses to Environmental Change. This Network brings together researchers within archaeology and environmental sciences to develop cross-disciplinary and internationally comparative approaches to understanding past human responses to rapid environmental change. Integration of skills and perspectives from the Humanities and Sciences will create a generation of scholars able to work across different theoretical frameworks to formulate credible ....Sustainable Futures through Understanding Past Human Responses to Environmental Change. This Network brings together researchers within archaeology and environmental sciences to develop cross-disciplinary and internationally comparative approaches to understanding past human responses to rapid environmental change. Integration of skills and perspectives from the Humanities and Sciences will create a generation of scholars able to work across different theoretical frameworks to formulate credible responses to the challenge of creating sustainable societies in a changing world. Through a greater understanding of past societies' reactions to rapid environmental change, the Network will build on existing leading edge research and create a more informed guide to a sustainable future.Read moreRead less
Tracking 3000 years of agricultural adaptation to the resource poor, climate sensitive and remote Solomon Islands using biomarkers and palaeoecology. Establishing research programs with Pacific neighbours benefits Australia's relations with Pacific Island countries generally. This project applies novel research methods to understanding human adaptations to long-term environmental and climatic fluctuations. It will address the National Research Priority goal of responding to climate variability b ....Tracking 3000 years of agricultural adaptation to the resource poor, climate sensitive and remote Solomon Islands using biomarkers and palaeoecology. Establishing research programs with Pacific neighbours benefits Australia's relations with Pacific Island countries generally. This project applies novel research methods to understanding human adaptations to long-term environmental and climatic fluctuations. It will address the National Research Priority goal of responding to climate variability by advancing our understanding of recent climate change in the Australia/Pacific region. It will show that Australian researchers can play a significant role in understanding the spread of humans across the Pacific, and the environmental adaptations required by populations in resource depleted environments. It will increase collaboration between research institutions focusing on the Australia/Pacific region.Read moreRead less
Development Of Therapeutically Useful Human Artificial Chromosomes For Gene Delivery And Optimal Gene Expression
Funder
National Health and Medical Research Council
Funding Amount
$496,986.00
Summary
Gene therapy is an exciting new form of treatment for genetic disorders aimed at providing long-term correction of the problems at source - namely the affected gene. The biggest technical hurdle facing gene therapy is to be able to deliver the therapeutic genes efficiently and safely into patient cells. Many gene therapy protocols are currently being trialled clinically. These protocols, based mostly on the use of attenuated viruses to deliver the genes, carry potential risks to the patients in ....Gene therapy is an exciting new form of treatment for genetic disorders aimed at providing long-term correction of the problems at source - namely the affected gene. The biggest technical hurdle facing gene therapy is to be able to deliver the therapeutic genes efficiently and safely into patient cells. Many gene therapy protocols are currently being trialled clinically. These protocols, based mostly on the use of attenuated viruses to deliver the genes, carry potential risks to the patients in terms of infection, immune response, and germline modification. We have developed the first stage of a new technology for gene delivery that does not require the use of viruses. This technology is based on the generation of human artificial chromosomes, which are smaller versions of the naturally occurring chromosomes that carry all the genes inside our cells. Safety in these artificial chromosomes comes from the use of entirely human materials for their engineering. These artificial chromosomes also have other advantages over the viral approaches, including allowing large genes to be carried, and providing a permanent cure in a single treatment. We have already successfully constructed, published, and patented a number of first-generation human artificial chromosomes. The current project aims to complete the next proof-of-concept milestone towards the further development of this technology. Specifically, we propose to demonstrate the ability of the artificial chromosomes to carry genes and provide sustainable expression of these genes in cells and in animal models. Success in this study will allow the technology to proceed rapidly into commercialisation and clinical trial as a new improved tool for gene delivery and gene therapy.Read moreRead less
Using fossil insects and plants to recognise past human impacts on Pacific island biodiversity. This project will enhance our ability to characterise human impact on island biodiversity. It will develop novel research methods that can be applied in the Australian context to understand changes in biodiversity that come with human impact. The contemporary emphasis on biosecurity in the protection of Australia's unique environment against human-introduced exotic pests and diseases can be better und ....Using fossil insects and plants to recognise past human impacts on Pacific island biodiversity. This project will enhance our ability to characterise human impact on island biodiversity. It will develop novel research methods that can be applied in the Australian context to understand changes in biodiversity that come with human impact. The contemporary emphasis on biosecurity in the protection of Australia's unique environment against human-introduced exotic pests and diseases can be better understood in the context of past introductions. Our project will demonstrate the role Australian archaeologists and natural scientists can play in understanding the spread of humans across the Pacific and the environmental consequences of colonisation. It will increase collaboration between research institutions in the Australia/Pacific region.Read moreRead less
Role Of SPPL2A On B Cell Survival And Antibody Production In Mice And Humans
Funder
National Health and Medical Research Council
Funding Amount
$592,989.00
Summary
B lymphocytes are a specialised type of blood cells that produce antibodies in response to a pathogen or a vaccine. We have recently discovered that all mature B cells depend for their survival on a previously unknown protein called SPPL2A. This application will investigate the molecular mechanism through which SPPL2A contributes to the survival of B cells. We will also investigate if humans with currently unexplained B cell deficiency have mutations in SPPL2A.
Metaphotonics and metasurfaces for disruptive sensing technologies. This project aims to address a big challenge in nanophotonics by developing revolutionary methods for efficient chiral sensing of molecules without the need for spectrometry, frequency scanning, or moving mechanical parts, and to enhance chiroptical signals a hundredfold with the help of metasurface structures. Resonant metasurfaces are arrays of engineered dielectric nanoparticles with extraordinary characteristics, and they wo ....Metaphotonics and metasurfaces for disruptive sensing technologies. This project aims to address a big challenge in nanophotonics by developing revolutionary methods for efficient chiral sensing of molecules without the need for spectrometry, frequency scanning, or moving mechanical parts, and to enhance chiroptical signals a hundredfold with the help of metasurface structures. Resonant metasurfaces are arrays of engineered dielectric nanoparticles with extraordinary characteristics, and they would allow to overcome current limitations of chiral sensing analytical tools. Detecting chiral molecules in low concentrations is crucially important to many fields of biology, chemistry, and pharmacy, as well as to the food and cosmetics industries, constituting a market of tens of billions of dollars.Read moreRead less
Indian Textile Technology as archaeological evidence for population movements in Early Southeast Asia. This project uses archaeological textiles to investigate population movements in the late prehistoric period of Southeast Asia. It involves collaborative links between researchers from the Institute of Archaeology in Vietnam, the Centre for Southeast Asian Prehistory in Ho Chi Minh City, the Fine Arts Department of Thailand and museums and archaeological institutions in South India. It not only ....Indian Textile Technology as archaeological evidence for population movements in Early Southeast Asia. This project uses archaeological textiles to investigate population movements in the late prehistoric period of Southeast Asia. It involves collaborative links between researchers from the Institute of Archaeology in Vietnam, the Centre for Southeast Asian Prehistory in Ho Chi Minh City, the Fine Arts Department of Thailand and museums and archaeological institutions in South India. It not only profiles Australian expertise in Southeast Asia but facilitates high levels of communication and the exchange of ideas. Read moreRead less