Evaluating The Genetic Contribution To Rheumatic Heart Disease Pathogenesis In Australian Aboriginal And Torres Strait Islander Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,782,074.00
Summary
Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.
Most eye diseases have a genetic contribution, whether rare disorders affecting children such as retinoblastoma or congenital cataracts through to common disorders of older people such as myopia, age-related macular degeneration or glaucoma. We will continue our successful research to find genes that cause these diseases and use this to improve patient care and prevent blindness. We will work out how families can use this genetic information to participate in trials to develop new treatments.
The Australian Parkinson's Project - Uncovering Genetic Risk Factors For Sporadic PD
Funder
National Health and Medical Research Council
Funding Amount
$768,546.00
Summary
Parkinson s disease (PD) is a progressively disabling movement disorder afflicting many elderly Australians. It is caused by the degeneration of specific nerve cells in the brain that produce certain chemicals and patients suffer from an inability to move fluently (or ultimately at all). At present we do not know what triggers this neurodegeneration, but it is believed that complex interactions between inherited (genetic) and environmental factors contribute significantly to the phenomenon. This ....Parkinson s disease (PD) is a progressively disabling movement disorder afflicting many elderly Australians. It is caused by the degeneration of specific nerve cells in the brain that produce certain chemicals and patients suffer from an inability to move fluently (or ultimately at all). At present we do not know what triggers this neurodegeneration, but it is believed that complex interactions between inherited (genetic) and environmental factors contribute significantly to the phenomenon. This project aims to learn more about these complex interactions and their association with PD. People with PD and unaffected individuals will be recruited from throughout Australia and we will look for specific combinations of genetic, environmental and lifestyle factors that either increase or decrease an individual's risk for PD. This research will identify the most common dominant genetic and environmental influences for PD in Australia, enabling scientists to focus on the most relevant biological pathways to target therapeutically.Read moreRead less
The Unique Nature Of Gamma Delta T Cell Recognition Resolved Through Interaction With H2-Q10
Funder
National Health and Medical Research Council
Funding Amount
$699,031.00
Summary
The liver is important for both digestion and immunity. Given these opposing functions, the liver must exert control points that prevent the immune system from recognising food products. We have now identified a new molecular target that controls the development of immune cells in the liver.
Psychosocial Aspects Of Genomic Testing For Breast Cancer Risk
Funder
National Health and Medical Research Council
Funding Amount
$108,902.00
Summary
Assessing a woman’s breast cancer risk by profiling polygenic risk represents a new approach in the familial cancer setting. My study is part of a program of research that aims to facilitate translation of polygenic risk information into clinical practice. For this, I will invite 400 women to receive their personal polygenic result and i) assess interest in receiving this result; ii) assess psychological and behavioural outcomes of receiving or not receiving their personal polygenic risk result
The canonical stratification of jet spaces. Singularities occur everywhere in nature, from the formation and collapse of stars to the morphology of living embryos. They appear whenever the geometry of surfaces or spaces undergoes a process of twisting, folding, or collapsing on itself. Singularity Theory is the study of such phenomena, an important branch of modern mathematics which has close connections with many other branches of mathematics and applied sciences. Singularity Theory lies at the ....The canonical stratification of jet spaces. Singularities occur everywhere in nature, from the formation and collapse of stars to the morphology of living embryos. They appear whenever the geometry of surfaces or spaces undergoes a process of twisting, folding, or collapsing on itself. Singularity Theory is the study of such phenomena, an important branch of modern mathematics which has close connections with many other branches of mathematics and applied sciences. Singularity Theory lies at the crossroads of the paths connecting the most important areas of applications of mathematics with its most abstract parts. Analytic Singularity Theory is a central part of Singularity Theory. This project would lead to substantially new advancements in Analytic Singularity Theory.Read moreRead less
Early settlements in Upper Burma (Myanmar): an experiment in urban living. This project directly increases access for Australian research to a previously self-isolated nation, Myanmar. It contributes to better understanding of our region and our world by examining how past communities worked together and how they dealt with social and environmental stress.
Chorasmian temples: an archaeological study of early Zoroastrianism and its precursors in Central Asia. The project is a collaboration with the Uzbek Academy of Sciences. National benefits to Australia are in international relations and in broadening our understanding of cultural issues in the potentially volatile and politically significant region of Central Asia. The team has developed a high profile in Uzbekistan and internationally, reflecting well on Australia's cultural strengths, intern ....Chorasmian temples: an archaeological study of early Zoroastrianism and its precursors in Central Asia. The project is a collaboration with the Uzbek Academy of Sciences. National benefits to Australia are in international relations and in broadening our understanding of cultural issues in the potentially volatile and politically significant region of Central Asia. The team has developed a high profile in Uzbekistan and internationally, reflecting well on Australia's cultural strengths, international involvement and support for developing countries in Asia. Our research features regularly in the Uzbek media and has the personal approval of President Karimov. We are involved with Zoroastrian and Parsi communities in Australia and overseas, particularly in India and the USA, and our results are published regularly in the community press.Read moreRead less
East meets West: an archaeological study of early contact between China and Eurasia. The project will link Chinese and Australian researchers in a collaborative programme exploring the origins of cultural contact between China and the West. Through the work of a team of international specialists, this fresh initiative will bring western analytical techniques together with Chinese archaeological experience to create a new and robust picture of the evidence for early cultural contact. From this we ....East meets West: an archaeological study of early contact between China and Eurasia. The project will link Chinese and Australian researchers in a collaborative programme exploring the origins of cultural contact between China and the West. Through the work of a team of international specialists, this fresh initiative will bring western analytical techniques together with Chinese archaeological experience to create a new and robust picture of the evidence for early cultural contact. From this we will study the early movements of Indo-European populations and examine the question of the origins of early metal production in China.Read moreRead less
With or without pots: Investigating the archaeology of human settlement on Santa Isabel, western Solomon Islands. Following the recent civil unrest in the Solomon Islands, the SI National and Provincial Governments, as well as community bodies, have identified a better understanding of the past and the revival of traditional systems and knowledge (Kastom) as a route to stability and cohesion throughout the region. This study responds to direct requests from the Santa Isabel community for assist ....With or without pots: Investigating the archaeology of human settlement on Santa Isabel, western Solomon Islands. Following the recent civil unrest in the Solomon Islands, the SI National and Provincial Governments, as well as community bodies, have identified a better understanding of the past and the revival of traditional systems and knowledge (Kastom) as a route to stability and cohesion throughout the region. This study responds to direct requests from the Santa Isabel community for assistance with archaeological research and the recording of cultural histories. By assisting a Pacific neighbour to develop a more durable, internally generated basis for social and economic development, Australia not only encourages security in the region, but also increases its engagment with and understanding of adjacent cultures.Read moreRead less