Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in ....Stochastic Modelling of Genetic Regulatory Networks: Subtitle - Genetic Regulation is a Noisy Business. The completion of the human genome marked the culmination of one hundred years of reductionist science in cell biology. Although further bioinformatics analysis will continue, the focus is shifting towards synthesis and understanding how the regulatory genetic components dynamically interact to form functional phenotypes. The key to this is the understanding of the roles of stochasticity in cellular processes. This project will explore these roles and will develop an integrated complex systems modelling, simulation and visualisation framework. This will be used on an exemplar application for lineage commitment in haematopoiesis and for exploring and validating genetic regulatory models in general.Read moreRead less
Neutron Scattering in Biology. Australia's Replacement Research Reactor will be a world-class neutron source, and represents the country's largest single investment in scientific research infrastructure. It is now essential to stimulate its production of high-quality research in materials science, chemistry and biology. The applicant is a recognised world leader in the field of neutron scattering research, particularly in biology. His presence in the Bragg Institute, which manages the neutron ....Neutron Scattering in Biology. Australia's Replacement Research Reactor will be a world-class neutron source, and represents the country's largest single investment in scientific research infrastructure. It is now essential to stimulate its production of high-quality research in materials science, chemistry and biology. The applicant is a recognised world leader in the field of neutron scattering research, particularly in biology. His presence in the Bragg Institute, which manages the neutron scattering instruments on the reactor, will provide direction and impetus for the science that will be initiated there, advancing applications in materials science, medicine and biotechnology.Read moreRead less
Self organization in (bio)molecular systems: Simulating the folding and aggregation of peptides, proteins and lipids. Molecular self-assembly is a basic property of living systems. Most proteins fold spontaneously and then further self-organize into functional complexes, effectively biological machines. Understanding how this occurs is a fundamental theoretical challenge with widespread application. Work will focus on developing methodology to simulate, computationally, the folding and aggrega ....Self organization in (bio)molecular systems: Simulating the folding and aggregation of peptides, proteins and lipids. Molecular self-assembly is a basic property of living systems. Most proteins fold spontaneously and then further self-organize into functional complexes, effectively biological machines. Understanding how this occurs is a fundamental theoretical challenge with widespread application. Work will focus on developing methodology to simulate, computationally, the folding and aggregation of peptides, proteins, and lipids. The aim is to accurately predict the structures of small peptides in solution and to refine crude models of larger molecules (complexes). This will facilitate the development of peptide based therapeutics and is essential in exploiting the growing volume of genetic information in biology and medicine.Read moreRead less
Complex Architecture and Convergent Design. After breaking the design code for Gaudí's Sagrada Família Church in 1979, completing the still unfinished church has required Mark Burry to pioneer groundbreaking architectural and construction design methodologies and practices. His current work is on the computer modelling and dynamic simulation of complex design and construction problems, and methods for multi-disciplinary and distributed team collaboration. This work has high impact industry appli ....Complex Architecture and Convergent Design. After breaking the design code for Gaudí's Sagrada Família Church in 1979, completing the still unfinished church has required Mark Burry to pioneer groundbreaking architectural and construction design methodologies and practices. His current work is on the computer modelling and dynamic simulation of complex design and construction problems, and methods for multi-disciplinary and distributed team collaboration. This work has high impact industry applications. At the intersection of so many fields of industrial research, Mark Burry's work acts as a catalyst and accelerator for technology transfer and innovation across the architectural, design and construction industries.Read moreRead less
Nonparametric Statistical Methods -- New Directions, Theory and Applications. The research program will take Australia to the forefront of contemporary work in nonparametric statistics, and assist greatly in the training of a new generation of Australian statistical scientists. It will contribute significantly to restoring the health of this strategically important field, in Australian universities and in the nation more generally. The projects outlined in the proposal address problems arising ....Nonparametric Statistical Methods -- New Directions, Theory and Applications. The research program will take Australia to the forefront of contemporary work in nonparametric statistics, and assist greatly in the training of a new generation of Australian statistical scientists. It will contribute significantly to restoring the health of this strategically important field, in Australian universities and in the nation more generally. The projects outlined in the proposal address problems arising in astronomy, economics, engineering, defence, health and image analysis, but the potential areas of impact are broader even than this. This diversity illustrates the extraordinary potential, and strategic significance, of statistics to Australia. Read moreRead less