Development of population-level algorithms for modelling genomic variation and its impact on cellular function in animals and plants. The purpose of this project is to develop mathematical and computational tools which will enable researchers to model high-throughput biological data at the population level. These models will be used to uncover the effect that genetic variation has on the physiology of the cell and the organism.
High Predictive Performance Models via Semi-Parametric Survival Regression. This project will develop novel statistical models for high prediction performance. When applied to help doctor to treat patients, these models allow the users to include gene or other biomarkers for predicting effectiveness of a treatment. When applied to risk management in finance, these models are capable to include an organization's or individual's ongoing finance status to predict, for example, the probability of or ....High Predictive Performance Models via Semi-Parametric Survival Regression. This project will develop novel statistical models for high prediction performance. When applied to help doctor to treat patients, these models allow the users to include gene or other biomarkers for predicting effectiveness of a treatment. When applied to risk management in finance, these models are capable to include an organization's or individual's ongoing finance status to predict, for example, the probability of or time to loan default. Innovative computational methods will be developed for fitting these models. Compared to traditional prediction method, this approach allows greater flexibility while being superior in terms of statistical accuracy and bias. Extensive analyses of healthcare data from diverse fields will be undertaken.Read moreRead less
Developing mathematical models and statistical methods to understand the dynamics of infectious diseases: stochasticity, structure and inference. Infectious diseases remain a major contributor to mortality and illness worldwide. The potential for future severe pandemics also continues to present a substantial threat to our health and well-being. Mathematics and statistics are increasingly becoming part of the arsenal used by governments to combat the invasion and spread of infectious diseases. I ....Developing mathematical models and statistical methods to understand the dynamics of infectious diseases: stochasticity, structure and inference. Infectious diseases remain a major contributor to mortality and illness worldwide. The potential for future severe pandemics also continues to present a substantial threat to our health and well-being. Mathematics and statistics are increasingly becoming part of the arsenal used by governments to combat the invasion and spread of infectious diseases. In such work, three themes have emerged as having the potential to revolutionise the modelling of infectious diseases: stochasticity, structure (both age and spatial), and inference. This project will develop state-of-the-art techniques, at the interface of these themes, of critical importance to understanding the dynamics of infectious diseases.Read moreRead less